IL2RG
The protein encoded by this gene is an important signaling component of many interleukin receptors, including those of interleukin -2, -4, -7 and -21, and is thus referred to as the common gamma chain. Mutations in this gene cause X-linked severe combined immunodeficiency (XSCID), as well as X-linked combined immunodeficiency (XCID), a less severe immunodeficiency disorder. [provided by RefSeq, Mar 2010]
Full Name
Interleukin 2 Receptor Subunit Gamma
Function
Common subunit for the receptors for a variety of interleukins. Probably in association with IL15RA, involved in the stimulation of neutrophil phagocytosis by IL15 (PubMed:15123770).
Biological Process
Cytokine-mediated signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Immune responseManual Assertion Based On ExperimentTAS:ProtInc
Interleukin-15-mediated signaling pathwayManual Assertion Based On ExperimentIMP:UniProtKB
Interleukin-2-mediated signaling pathwayIEA:GOC
Interleukin-4-mediated signaling pathwayIEA:GOC
Interleukin-7-mediated signaling pathwayIEA:GOC
Positive regulation of phagocytosisManual Assertion Based On ExperimentIMP:UniProtKB
Signal transduction1 PublicationNAS:ProtInc
Immune responseManual Assertion Based On ExperimentTAS:ProtInc
Interleukin-15-mediated signaling pathwayManual Assertion Based On ExperimentIMP:UniProtKB
Interleukin-2-mediated signaling pathwayIEA:GOC
Interleukin-4-mediated signaling pathwayIEA:GOC
Interleukin-7-mediated signaling pathwayIEA:GOC
Positive regulation of phagocytosisManual Assertion Based On ExperimentIMP:UniProtKB
Signal transduction1 PublicationNAS:ProtInc
Cellular Location
Cell membrane; Cell surface
Involvement in disease
Severe combined immunodeficiency X-linked T-cell-negative/B-cell-positive/NK-cell-negative (XSCID):
A form of severe combined immunodeficiency (SCID), a genetically and clinically heterogeneous group of rare congenital disorders characterized by impairment of both humoral and cell-mediated immunity, leukopenia, and low or absent antibody levels. Patients present in infancy recurrent, persistent infections by opportunistic organisms. The common characteristic of all types of SCID is absence of T-cell-mediated cellular immunity due to a defect in T-cell development.
X-linked combined immunodeficiency (XCID):
Less severe form of X-linked immunodeficiency with a less severe degree of deficiency in cellular and humoral immunity than that seen in XSCID.
A form of severe combined immunodeficiency (SCID), a genetically and clinically heterogeneous group of rare congenital disorders characterized by impairment of both humoral and cell-mediated immunity, leukopenia, and low or absent antibody levels. Patients present in infancy recurrent, persistent infections by opportunistic organisms. The common characteristic of all types of SCID is absence of T-cell-mediated cellular immunity due to a defect in T-cell development.
X-linked combined immunodeficiency (XCID):
Less severe form of X-linked immunodeficiency with a less severe degree of deficiency in cellular and humoral immunity than that seen in XSCID.
Topology
Extracellular: 23-262
Helical: 263-283
Cytoplasmic: 284-369
Helical: 263-283
Cytoplasmic: 284-369
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Anti-IL2RG antibodies
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CompareTarget: IL2RG
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse
Clone: 004
Application*: E
Target: IL2RG
Host: Rat
Antibody Isotype: IgG2b
Specificity: Mouse
Clone: A549
Application*: FC
Target: IL2RG
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: 644337
Application*: WB
Target: IL2RG
Host: Rat
Antibody Isotype: IgG2b, κ
Specificity: Mouse
Clone: TUGm2
Application*: F
Target: IL2RG
Host: Rat
Antibody Isotype: IgG2a, κ
Specificity: Mouse
Clone: CBYY-C0283
Application*: F, N
Target: IL2RG
Host: Rat
Antibody Isotype: IgG2
Specificity: Mouse
Clone: CBYY-I1130
Application*: F
Target: IL2RG
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBYY-I1115
Application*: F, N
Target: IL2RG
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse
Clone: CBYY-I0969
Application*: E
Target: IL2RG
Host: Rat
Antibody Isotype: IgG2b, λ
Specificity: Human
Clone: CBYY-I0480
Application*: F
Target: IL2RG
Host: Rat
Antibody Isotype: IgG2b
Specificity: Mouse
Clone: 3E12
Application*: B, P, F
Target: IL2RG
Host: Rat
Antibody Isotype: IgG2a, κ
Specificity: Mouse
Clone: 4G3
Application*: F
Target: IL2RG
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse
Clone: 005
Application*: E, ED
Target: IL2RG
Host: Rat
Antibody Isotype: IgG2b
Specificity: Mouse
Clone: 135727
Application*: IS, MC
Target: IL2RG
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse
Clone: 011
Application*: EC, F, IC/IF, IF
Target: IL2RG
Host: Human
Antibody Isotype: IgG4
Specificity: Human, Monkey
Clone: 6F3
Application*: E
Target: IL2RG
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT2164
Application*: WB
Target: IL2RG
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT3285
Application*: WB, F
Target: IL2RG
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: MM0195-7A23
Application*: WB, B/N
Target: IL2RG
Host: Rat
Antibody Isotype: IgG2b, λ
Specificity: Human
Clone: TUGh4
Application*: F
Target: IL2RG
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBWJC-2197
Application*: F
Target: IL2RG
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-4719
Application*: WB, N, E
Target: IL2RG
Host: Human
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXC-0802
Application*: F
Target: IL2RG
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBXC-1269
Application*: F
Target: IL2RG
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXC-1152
Application*: N
Target: IL2RG
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBXC-1090
Application*: IS
Target: IL2RG
Host: Rat
Antibody Isotype: IgG2b
Specificity: Mouse
Clone: CBYY-C2573
Application*: B, IP, F
Target: IL2RG
Host: Rat
Antibody Isotype: IgG2b
Specificity: Mouse
Clone: CBYY-C0502
Application*: F
Target: IL2RG
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBFYC-2770
Application*: E
Target: IL2RG
Host: Rat
Antibody Isotype: IgG2b
Specificity: Mouse
Clone: CBFYC-0268
Application*: F
Target: IL2RG
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse
Clone: CBFYC-0109
Application*: EC, F, IC, IF
Target: IL2RG
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 7A23
Application*: N, WB
Target: IL2RG
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 633162
Application*: F, N, MC
Target: IL2RG
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: 044
Application*: E
Target: IL2RG
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 31134
Application*: IS, MC
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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