Human IL2RG ELISA Kit (V2LY-0626-LY4476)

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Tested Data
Datasheet
SDS
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Basic Information

Sensitivity
0.046 ng/mL
Detection Range
0.1-40 ng/mL
Sample Type
Serum, Plasma, cell culture supernates
Specificity
Human
Assay Type
Sandwich
Reactivity
Human
Assay Time
1.5 h
Molecule Mass
42.3 kDa
Components
  • Pre-coated ELISA Plate: 12 wells * 8 detachable strips
  • Standard solution: 0.5ml x1
  • Standard diluent: 3ml x1
  • Streptavidin-HRP: 6ml x1
  • Stop solution: 6ml x1
  • Substrate solution A: 6ml x1
  • Substrate solution B: 6ml x1
  • Wash buffer concentrate (25x): 20ml x1
  • Biotinylated antibody: 1ml x1

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 2-8°C
More Infomation

Target

Full Name
Interleukin 2 Receptor Subunit Gamma
Function
Common subunit for the receptors for a variety of interleukins. Probably in association with IL15RA, involved in the stimulation of neutrophil phagocytosis by IL15 (PubMed:15123770).
Biological Process
Cytokine-mediated signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Immune responseManual Assertion Based On ExperimentTAS:ProtInc
Interleukin-15-mediated signaling pathwayManual Assertion Based On ExperimentIMP:UniProtKB
Interleukin-2-mediated signaling pathwayIEA:GOC
Interleukin-4-mediated signaling pathwayIEA:GOC
Interleukin-7-mediated signaling pathwayIEA:GOC
Positive regulation of phagocytosisManual Assertion Based On ExperimentIMP:UniProtKB
Signal transduction1 PublicationNAS:ProtInc
Cellular Location
Cell membrane; Cell surface
Involvement in disease
Severe combined immunodeficiency X-linked T-cell-negative/B-cell-positive/NK-cell-negative (XSCID):
A form of severe combined immunodeficiency (SCID), a genetically and clinically heterogeneous group of rare congenital disorders characterized by impairment of both humoral and cell-mediated immunity, leukopenia, and low or absent antibody levels. Patients present in infancy recurrent, persistent infections by opportunistic organisms. The common characteristic of all types of SCID is absence of T-cell-mediated cellular immunity due to a defect in T-cell development.
X-linked combined immunodeficiency (XCID):
Less severe form of X-linked immunodeficiency with a less severe degree of deficiency in cellular and humoral immunity than that seen in XSCID.
Topology
Extracellular: 23-262
Helical: 263-283
Cytoplasmic: 284-369

Tuovinen, E. A., Pöysti, S., Hamdan, F., Le, K. M., Keskitalo, S., Turunen, T., ... & Grönholm, J. (2023). Characterization of expanded gamma delta T cells from atypical X-SCID patient reveals preserved function and IL2RG-mediated signaling. Journal of clinical immunology, 43(2), 358-370.

Zheng, X., Huang, C., Lin, Y., Han, B., Chen, Y., Li, C., ... & Yan, S. (2023). Generation of inactivated IL2RG and RAG1 monkeys with severe combined immunodeficiency using base editing. Signal Transduction and Targeted Therapy, 8(1), 327.

Goncalves, P., Doisne, J. M., Eri, T., Charbit, B., Bondet, V., Posseme, C., ... & Milieu Intérieur Consortium. (2022). Defects in mucosal immunity and nasopharyngeal dysbiosis in HSC-transplanted SCID patients with IL2RG/JAK3 deficiency. Blood, The Journal of the American Society of Hematology, 139(17), 2585-2600.

Yue, X., Petersen, F., Shu, Y., Kasper, B., Magatsin, J. D. T., Ahmadi, M., ... & Riemekasten, G. (2021). Transfer of PBMC from SSc patients induces autoantibodies and systemic inflammation in Rag2-/-/IL2rg-/-mice. Frontiers in immunology, 12, 677970.

Hou, Y., Gratz, H. P., Ureña-Bailén, G., Gratz, P. G., Schilbach-Stückle, K., Renno, T., ... & Mezger, M. (2021). Somatic Reversion of a Novel IL2RG Mutation Resulting in Atypical X-Linked Combined Immunodeficiency. Genes, 13(1), 35.

Ren, J., Yu, D., Fu, R., An, P., Sun, R., Wang, Z., ... & Hu, Z. (2020). IL2RG‐deficient minipigs generated via CRISPR/Cas9 technology support the growth of human melanoma‐derived tumours. Cell Proliferation, 53(10), e12863.

Tuovinen, E. A., Grönholm, J., Öhman, T., Pöysti, S., Toivonen, R., Kreutzman, A., ... & Seppänen, M. R. (2020). Novel hemizygous IL2RG p.(Pro58Ser) mutation impairs IL-2 receptor complex expression on lymphocytes causing X-linked combined immunodeficiency. Journal of Clinical Immunology, 40, 503-514.

Boettcher, A. N., Li, Y., Ahrens, A. P., Kiupel, M., Byrne, K. A., Loving, C. L., ... & Tuggle, C. K. (2020). Novel engraftment and T cell differentiation of human hematopoietic cells in ART−/− IL2RG−/Y SCID pigs. Frontiers in Immunology, 11, 100.

Lim, C. K., Abolhassani, H., Appelberg, S. K., Sundin, M., & Hammarström, L. (2019). IL2RG hypomorphic mutation: identification of a novel pathogenic mutation in exon 8 and a review of the literature. Allergy, Asthma & Clinical Immunology, 15, 1-8.

Miggelbrink, A. M., Logan, B. R., Buckley, R. H., Parrott, R. E., Dvorak, C. C., Kapoor, N., ... & Pai, S. Y. (2018). B-cell differentiation and IL-21 response in IL2RG/JAK3 SCID patients after hematopoietic stem cell transplantation. Blood, The Journal of the American Society of Hematology, 131(26), 2967-2977.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Human Recombinant IL2RG protein, ECD, Biotin Conjugated, His & AVI Tag (CAT#: V2LY-0526-LY4878)

Human Recombinant IL2RG protein, hFc Tag (CAT#: V2LY-0526-LY4879)

Human Recombinant IL2RG protein, His Tag (CAT#: V2LY-0526-LY4880)

Human Recombinant IL2RG protein, His Tag-1 (CAT#: V2LY-0526-LY4881)

Human Recombinant IL2RG protein, hFc Tag-1 (CAT#: V2LY-0526-LY4882)

Mouse Recombinant IL2RG protein, ECD, hFc Tag (CAT#: V2LY-0526-LY8529)

Mouse Recombinant IL2RG protein, His & hFc Tag (CAT#: V2LY-0526-LY8530)

Mouse Recombinant IL2RG protein, His Tag (CAT#: V2LY-0526-LY8531)

Mouse Recombinant IL2RG protein, His Tag-1 (CAT#: V2LY-0526-LY8532)

Rat Recombinant IL2RG protein, hFc Tag (CAT#: V2LY-0526-LY9472)

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Rat Anti-IL2RG Recombinant Antibody (3E12) (CAT#: CBMAB-C5939-LY)

Rat Recombinant IL2RG protein, His Tag (CAT#: V2LY-0526-LY9473)

Mouse Anti-IL2RG Recombinant Antibody (CBXC-1269) (CAT#: CBMAB-C1536-CQ)

Human Recombinant IL2RG protein, His Tag-1 (CAT#: V2LY-0526-LY4881)

Mouse Anti-IL2RG Recombinant Antibody (633162) (CAT#: CBMAB-C7897-LY)

Human Recombinant IL2RG protein, hFc Tag-1 (CAT#: V2LY-0526-LY4882)

Mouse Anti-IL2RG Recombinant Antibody (CBXS-4719) (CAT#: CBMAB-S1950-CQ)

Mouse Anti-IL2RG Recombinant Antibody (31134) (CAT#: CBMAB-C0946-LY)

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For research use only. Not intended for any clinical use.

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