Rat Recombinant IL2RG protein, hFc Tag (V2LY-0526-LY9472)

Name: Rat Recombinant IL2RG protein, hFc Tag
SKU: V2LY-0526-LY9472
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

HEK293 Cells

Protein Species

Rat

Tag

hFc Tag

Protein Construction

This product is Rat Recombinant IL2RG protein, hFc Tag consist of Amino Acid: 1-262 and predicts a molecular mass of 55 kDa.

Molecule Mass

55 kDa

Sequence

Amino Acid: 1-262

Species

Rat

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

>85% as determined by SDS-PAGE

Endotoxin

Please contact us for more information.

Format

Lyophilized

Reconstitution

Allow the vial and reconstitution buffer to equilibrate to room temperature. Briefly centrifuge or tap down the vial to ensure that all lyophilized powder is collected at the bottom of the vial. For the reconstitution of this product, we recommend adding PBS or sterile water to achieve a final antibody concentration of 1 mg/mL. Allow the vial to reconstitute for 10-15 minutes at room temperature with gentle agitation. Avoid vigorous shaking that can cause foaming and antibody denaturation. Aliquot into volumes based on your experiment and store liquid protein at -20°C or -80°C for long time.

Buffer

Lyophilized from sterile

Preservative

None

Storage

Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

More Infomation

Target

Full Name

Interleukin 2 Receptor Subunit Gamma

Function

Common subunit for the receptors for a variety of interleukins. Probably in association with IL15RA, involved in the stimulation of neutrophil phagocytosis by IL15 (PubMed:15123770).

Biological Process

Cytokine-mediated signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Immune responseManual Assertion Based On ExperimentTAS:ProtInc
Interleukin-15-mediated signaling pathwayManual Assertion Based On ExperimentIMP:UniProtKB
Interleukin-2-mediated signaling pathwayIEA:GOC
Interleukin-4-mediated signaling pathwayIEA:GOC
Interleukin-7-mediated signaling pathwayIEA:GOC
Positive regulation of phagocytosisManual Assertion Based On ExperimentIMP:UniProtKB
Signal transduction1 PublicationNAS:ProtInc

Cellular Location

Cell membrane; Cell surface

Involvement in disease

Severe combined immunodeficiency X-linked T-cell-negative/B-cell-positive/NK-cell-negative (XSCID):
A form of severe combined immunodeficiency (SCID), a genetically and clinically heterogeneous group of rare congenital disorders characterized by impairment of both humoral and cell-mediated immunity, leukopenia, and low or absent antibody levels. Patients present in infancy recurrent, persistent infections by opportunistic organisms. The common characteristic of all types of SCID is absence of T-cell-mediated cellular immunity due to a defect in T-cell development.
X-linked combined immunodeficiency (XCID):
Less severe form of X-linked immunodeficiency with a less severe degree of deficiency in cellular and humoral immunity than that seen in XSCID.

Topology

Extracellular: 23-262
Helical: 263-283
Cytoplasmic: 284-369

Tuovinen, E. A., Pöysti, S., Hamdan, F., Le, K. M., Keskitalo, S., Turunen, T., ... & Grönholm, J. (2023). Characterization of expanded gamma delta T cells from atypical X-SCID patient reveals preserved function and IL2RG-mediated signaling. Journal of clinical immunology, 43(2), 358-370.

Zheng, X., Huang, C., Lin, Y., Han, B., Chen, Y., Li, C., ... & Yan, S. (2023). Generation of inactivated IL2RG and RAG1 monkeys with severe combined immunodeficiency using base editing. Signal Transduction and Targeted Therapy, 8(1), 327.

Goncalves, P., Doisne, J. M., Eri, T., Charbit, B., Bondet, V., Posseme, C., ... & Milieu Intérieur Consortium. (2022). Defects in mucosal immunity and nasopharyngeal dysbiosis in HSC-transplanted SCID patients with IL2RG/JAK3 deficiency. Blood, The Journal of the American Society of Hematology, 139(17), 2585-2600.

Yue, X., Petersen, F., Shu, Y., Kasper, B., Magatsin, J. D. T., Ahmadi, M., ... & Riemekasten, G. (2021). Transfer of PBMC from SSc patients induces autoantibodies and systemic inflammation in Rag2-/-/IL2rg-/-mice. Frontiers in immunology, 12, 677970.

Hou, Y., Gratz, H. P., Ureña-Bailén, G., Gratz, P. G., Schilbach-Stückle, K., Renno, T., ... & Mezger, M. (2021). Somatic Reversion of a Novel IL2RG Mutation Resulting in Atypical X-Linked Combined Immunodeficiency. Genes, 13(1), 35.

Ren, J., Yu, D., Fu, R., An, P., Sun, R., Wang, Z., ... & Hu, Z. (2020). IL2RG‐deficient minipigs generated via CRISPR/Cas9 technology support the growth of human melanoma‐derived tumours. Cell Proliferation, 53(10), e12863.

Tuovinen, E. A., Grönholm, J., Öhman, T., Pöysti, S., Toivonen, R., Kreutzman, A., ... & Seppänen, M. R. (2020). Novel hemizygous IL2RG p.(Pro58Ser) mutation impairs IL-2 receptor complex expression on lymphocytes causing X-linked combined immunodeficiency. Journal of Clinical Immunology, 40, 503-514.

Boettcher, A. N., Li, Y., Ahrens, A. P., Kiupel, M., Byrne, K. A., Loving, C. L., ... & Tuggle, C. K. (2020). Novel engraftment and T cell differentiation of human hematopoietic cells in ART−/− IL2RG−/Y SCID pigs. Frontiers in Immunology, 11, 100.

Lim, C. K., Abolhassani, H., Appelberg, S. K., Sundin, M., & Hammarström, L. (2019). IL2RG hypomorphic mutation: identification of a novel pathogenic mutation in exon 8 and a review of the literature. Allergy, Asthma & Clinical Immunology, 15, 1-8.

Miggelbrink, A. M., Logan, B. R., Buckley, R. H., Parrott, R. E., Dvorak, C. C., Kapoor, N., ... & Pai, S. Y. (2018). B-cell differentiation and IL-21 response in IL2RG/JAK3 SCID patients after hematopoietic stem cell transplantation. Blood, The Journal of the American Society of Hematology, 131(26), 2967-2977.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Human Recombinant IL2RG protein, ECD, Biotin Conjugated, His & AVI Tag (CAT#: V2LY-0526-LY4878)

Human Recombinant IL2RG protein, hFc Tag (CAT#: V2LY-0526-LY4879)

Human Recombinant IL2RG protein, His Tag (CAT#: V2LY-0526-LY4880)

Human Recombinant IL2RG protein, His Tag-1 (CAT#: V2LY-0526-LY4881)

Human Recombinant IL2RG protein, hFc Tag-1 (CAT#: V2LY-0526-LY4882)

Mouse Recombinant IL2RG protein, ECD, hFc Tag (CAT#: V2LY-0526-LY8529)

Mouse Recombinant IL2RG protein, His & hFc Tag (CAT#: V2LY-0526-LY8530)

Mouse Recombinant IL2RG protein, His Tag (CAT#: V2LY-0526-LY8531)

Mouse Recombinant IL2RG protein, His Tag-1 (CAT#: V2LY-0526-LY8532)

Rat Recombinant IL2RG protein, His Tag (CAT#: V2LY-0526-LY9473)

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Human Recombinant IL2RG protein, hFc Tag (CAT#: V2LY-0526-LY4879)

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Isotype control

For research use only. Not intended for any clinical use.

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