IL34

Interleukin-34 is a cytokine that promotes the differentiation and viability of monocytes and macrophages through the colony-stimulating factor-1 receptor (CSF1R; MIM 164770) (Lin et al., 2008 [PubMed 18467591]).[supplied by OMIM, May 2008]

Interleukin 34

Cytokine that promotes the proliferation, survival and differentiation of monocytes and macrophages. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, and in the regulation of bone resorption. Signaling via CSF1R and its downstream effectors stimulates phosphorylation of MAPK1/ERK2 AND MAPK3/ERK1.

Inflammatory responseIEA:UniProtKB-KW
Innate immune responseIEA:UniProtKB-KW
Interleukin-34-mediated signaling pathwayManual Assertion Based On ExperimentIDA:ARUK-UCL
Microglial cell proliferationIEA:Ensembl
Positive regulation of cell population proliferationManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of gene expressionIEA:Ensembl
Positive regulation of macrophage chemotaxisManual Assertion Based On ExperimentIDA:ARUK-UCL
Positive regulation of macrophage differentiationManual Assertion Based On ExperimentIDA:CACAO
Positive regulation of macrophage proliferationManual Assertion Based On ExperimentIDA:ARUK-UCL
Positive regulation of MAP kinase activityManual Assertion Based On ExperimentIDA:ARUK-UCL
Positive regulation of monocyte differentiationManual Assertion Based On ExperimentIDA:CACAO
Positive regulation of oligodendrocyte differentiationISS:UniProtKB
Positive regulation of protein phosphorylationManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of protein tyrosine kinase activityManual Assertion Based On ExperimentIDA:ARUK-UCL

Secreted