IL34

Interleukin-34 is a cytokine that promotes the differentiation and viability of monocytes and macrophages through the colony-stimulating factor-1 receptor (CSF1R; MIM 164770) (Lin et al., 2008 [PubMed 18467591]).[supplied by OMIM, May 2008]
Full Name
Interleukin 34
Function
Cytokine that promotes the proliferation, survival and differentiation of monocytes and macrophages. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, and in the regulation of bone resorption. Signaling via CSF1R and its downstream effectors stimulates phosphorylation of MAPK1/ERK2 AND MAPK3/ERK1.
Biological Process
Inflammatory responseIEA:UniProtKB-KW
Innate immune responseIEA:UniProtKB-KW
Interleukin-34-mediated signaling pathwayManual Assertion Based On ExperimentIDA:ARUK-UCL
Microglial cell proliferationIEA:Ensembl
Positive regulation of cell population proliferationManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of gene expressionIEA:Ensembl
Positive regulation of macrophage chemotaxisManual Assertion Based On ExperimentIDA:ARUK-UCL
Positive regulation of macrophage differentiationManual Assertion Based On ExperimentIDA:CACAO
Positive regulation of macrophage proliferationManual Assertion Based On ExperimentIDA:ARUK-UCL
Positive regulation of MAP kinase activityManual Assertion Based On ExperimentIDA:ARUK-UCL
Positive regulation of monocyte differentiationManual Assertion Based On ExperimentIDA:CACAO
Positive regulation of oligodendrocyte differentiationISS:UniProtKB
Positive regulation of protein phosphorylationManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of protein tyrosine kinase activityManual Assertion Based On ExperimentIDA:ARUK-UCL
Cellular Location
Secreted
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Anti-IL34 antibodies

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Mouse Anti-IL34 Recombinant Antibody (CBLC224-LY) (CBMAB-C11729-LY)

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Target: IL34
Host: Mouse
Antibody Isotype: IgG
Specificity: Mouse
Clone: CBLC224-LY
Application*: WB, IC, P, C, E
Datasheet SDS

Mouse Il34 ELISA Kit (V2LY-0626-LY5806)

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Target: Il34
Sensitivity: 0.00027 ng/mL
Detection Range: 0.0005-0.2 ng/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Mouse
Assay Type: Sandwich
Reactivity: Mouse
Datasheet SDS

Human IL34 ELISA Kit (2) (V2LY-0626-LY4769)

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Target: IL34
Sensitivity: 0.0076 ng/mL
Detection Range: 0.015-3 ng/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Human
Assay Type: Sandwich
Reactivity: Human
Datasheet SDS

Rat Il34 ELISA Kit (V2LY-0626-LY2397)

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Target: Il34
Sensitivity: 0.0073 ng/mL
Detection Range: 0.015-3 ng/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Rat
Assay Type: Sandwich
Reactivity: Rat
Datasheet SDS

Human IL34 ELISA Kit (V2LY-0626-LY228)

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Target: IL34
Sensitivity: 0.00023 ng/mL
Detection Range: 0.0005-0.15 ng/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Human
Assay Type: Sandwich
Reactivity: Human
Datasheet SDS

Mouse Recombinant IL34 protein, His Tag (V2LY-0526-LY8538)

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Target: IL34
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-235
Tag: His Tag
Datasheet SDS

Human Recombinant IL34 protein, His Tag (V2LY-0526-LY4899)

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Target: IL34
Expressed Host: CHO Stable Cells
Sequence: Amino Acid: 1-242
Tag: His Tag
Datasheet SDS

Mouse Anti-IL34 Recombinant Antibody (CBT770) (V2LY-0625-LY3290)

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Target: IL34
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBT770
Application*: WB, IF, IC, F, E
Datasheet SDS

Mouse Anti-IL34 Recombinant Antibody (CBT4600) (V2LY-0625-LY2462)

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Target: IL34
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT4600
Application*: WB, IC, F
Datasheet SDS

Mouse Anti-IL34 Recombinant Antibody (CBYY-I0987) (CBMAB-I2155-YY)

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Target: IL34
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-I0987
Application*: ED
Datasheet SDS

Rat Anti-IL34 Recombinant Antibody (CBYY-I0739) (CBMAB-I1641-YY)

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Target: IL34
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: CBYY-I0739
Application*: N
Datasheet SDS

Mouse Anti-IL34 (AA 58-217) Recombinant Antibody (578416) (CBMAB-I1403-YY)

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Target: IL34
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 578416
Application*: N, IS, MC
Datasheet SDS

Mouse Anti-IL34 Recombinant Antibody (CBYY-I0630) (CBMAB-I1402-YY)

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Target: IL34
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-I0630
Application*: EC
Datasheet SDS

Mouse Anti-IL34 Recombinant Antibody (CBYY-I0210) (CBMAB-I0559-YY)

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Target: IL34
Host: Mouse
Antibody Isotype: IgG2a, λ
Specificity: Human
Clone: CBYY-I0210
Application*: ED
Datasheet SDS

Mouse Anti-IL34 Recombinant Antibody (CBYY-I0209) (CBMAB-I0558-YY)

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Target: IL34
Host: Mouse
Antibody Isotype: IgG2b, λ
Specificity: Human
Clone: CBYY-I0209
Application*: E
Datasheet SDS

Mouse Anti-IL34 Recombinant Antibody (1D12) (CBMAB-I0557-YY)

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Target: IL34
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 1D12
Application*: E, F, IF, P, WB, IC
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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