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Mouse Anti-IL34 (AA 58-217) Recombinant Antibody (578416) (CBMAB-I1403-YY)

This product is Mouse antibody that recognizes IL34. The antibody 578416 can be used for immunoassay techniques such as: Neut, ICFC, CyTOF
See all IL34 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
578416
Antibody Isotype
IgG1
Application
Neut, ICFC, CyTOF

Basic Information

Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Lyophilized
Buffer
0.2 μm filtered solution in with Trehalose
Concentration
LYOPH
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
AA58-217

Target

Full Name
Interleukin 34
Introduction
Interleukin-34 is a cytokine that promotes the differentiation and viability of monocytes and macrophages through the colony-stimulating factor-1 receptor
Entrez Gene ID
146433
UniProt ID
Q6ZMJ4
Alternative Names
Interleukin 34
Function
Cytokine that promotes the proliferation, survival and differentiation of monocytes and macrophages. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, and in the regulation of bone resorption. Signaling via CSF1R and its downstream effectors stimulates phosphorylation of MAPK1/ERK2 AND MAPK3/ERK1.
Biological Process
Inflammatory responseIEA:UniProtKB-KW
Innate immune responseIEA:UniProtKB-KW
Interleukin-34-mediated signaling pathwayManual Assertion Based On ExperimentIDA:ARUK-UCL
Microglial cell proliferationIEA:Ensembl
Positive regulation of cell population proliferationManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of gene expressionIEA:Ensembl
Positive regulation of macrophage chemotaxisManual Assertion Based On ExperimentIDA:ARUK-UCL
Positive regulation of macrophage differentiationManual Assertion Based On ExperimentIDA:CACAO
Positive regulation of macrophage proliferationManual Assertion Based On ExperimentIDA:ARUK-UCL
Positive regulation of MAP kinase activityManual Assertion Based On ExperimentIDA:ARUK-UCL
Positive regulation of monocyte differentiationManual Assertion Based On ExperimentIDA:CACAO
Positive regulation of oligodendrocyte differentiationISS:UniProtKB
Positive regulation of protein phosphorylationManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of protein tyrosine kinase activityManual Assertion Based On ExperimentIDA:ARUK-UCL
Cellular Location
Secreted

Freuchet, A., Salama, A., Bézie, S., Tesson, L., Rémy, S., Humeau, R., ... & Guillonneau, C. (2022). IL‐34 deficiency impairs FOXP3+ Treg function in a model of autoimmune colitis and decreases immune tolerance homeostasis. Clinical and Translational Medicine, 12(8), e988.

Duarte, C., Akkaoui, J., Ho, A., Garcia, C., Yamada, C., & Movila, A. (2021). Age-dependent effects of the recombinant spike protein/SARS-CoV-2 on the M–CSF–and IL-34-differentiated macrophages in vitro. Biochemical and Biophysical Research Communications, 546, 97-102.

Freuchet, A., Salama, A., Remy, S., Guillonneau, C., & Anegon, I. (2021). IL-34 and CSF-1, deciphering similarities and differences at steady state and in diseases. Journal of Leukocyte Biology, 110(4), 771-796.

Otsuka, R., Wada, H., & Seino, K. I. (2021, April). IL-34, the rationale for its expression in physiological and pathological conditions. In Seminars in Immunology (Vol. 54, p. 101517). Academic Press.

Lelios, I., Cansever, D., Utz, S. G., Mildenberger, W., Stifter, S. A., & Greter, M. (2020). Emerging roles of IL-34 in health and disease. Journal of Experimental Medicine, 217(3), e20190290.

Blondy, T., d'Almeida, S. M., Briolay, T., Tabiasco, J., Meiller, C., Chéné, A. L., ... & Blanquart, C. (2020). Involvement of the M-CSF/IL-34/CSF-1R pathway in malignant pleural mesothelioma. Journal for immunotherapy of cancer, 8(1).

Su, Y., Yu, Y., Liu, C., Zhang, Y., Liu, C., Ge, M., ... & Meng, Q. (2020). Fate decision of satellite cell differentiation and self-renewal by miR-31-IL34 axis. Cell Death & Differentiation, 27(3), 949-965.

Lin, W., Xu, D., Austin, C. D., Caplazi, P., Senger, K., Sun, Y., ... & Zarrin, A. A. (2019). Function of CSF1 and IL34 in macrophage homeostasis, inflammation, and cancer. Frontiers in immunology, 10, 2019.

Easley-Neal, C., Foreman, O., Sharma, N., Zarrin, A. A., & Weimer, R. M. (2019). CSF1R ligands IL-34 and CSF1 are differentially required for microglia development and maintenance in white and gray matter brain regions. Frontiers in immunology, 10, 2199.

Zhao, Z., Pan, G., Tang, C., Li, Z., Zheng, D., Wei, X., & Wu, Z. (2018). IL-34 inhibits acute rejection of rat liver transplantation by inducing Kupffer cell M2 polarization. Transplantation, 102(6), e265-e274.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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