IRAK3

This gene encodes a member of the interleukin-1 receptor-associated kinase protein family. Members of this family are essential components of the Toll/IL-R immune signal transduction pathways. This protein is primarily expressed in monocytes and macrophages and functions as a negative regulator of Toll-like receptor signaling. Mutations in this gene are associated with a susceptibility to asthma. Alternate splicing results in multiple transcript variants. [provided by RefSeq, May 2010]

Interleukin 1 Receptor Associated Kinase 3

Putative inactive protein kinase which regulates signaling downstream of immune receptors including IL1R and Toll-like receptors (PubMed:10383454, PubMed:29686383).
Inhibits dissociation of IRAK1 and IRAK4 from the Toll-like receptor signaling complex by either inhibiting the phosphorylation of IRAK1 and IRAK4 or stabilizing the receptor complex (By similarity).
Upon IL33-induced lung inflammation, positively regulates expression of IL6, CSF3, CXCL2 and CCL5 mRNAs in dendritic cells (PubMed:29686383).

Cytokine-mediated signaling pathwayISS:UniProtKB
Interleukin-1-mediated signaling pathwayManual Assertion Based On ExperimentIMP:BHF-UCL
Intracellular signal transductionManual Assertion Based On ExperimentIBA:GO_Central
MyD88-dependent toll-like receptor signaling pathwayManual Assertion Based On ExperimentTAS:BHF-UCL
Negative regulation of cytokine-mediated signaling pathway1 PublicationIC:BHF-UCL
Negative regulation of innate immune responseBy SimilarityISS:BHF-UCL
Negative regulation of interleukin-12 productionManual Assertion Based On ExperimentIMP:BHF-UCL
Negative regulation of interleukin-6 productionManual Assertion Based On ExperimentIMP:BHF-UCL
Negative regulation of macrophage cytokine productionBy SimilarityISS:BHF-UCL
Negative regulation of MAP kinase activityManual Assertion Based On ExperimentIMP:BHF-UCL
Negative regulation of NF-kappaB transcription factor activityManual Assertion Based On ExperimentIMP:BHF-UCL
Negative regulation of protein catabolic processManual Assertion Based On ExperimentIMP:BHF-UCL
Negative regulation of protein-containing complex disassemblyManual Assertion Based On ExperimentIMP:BHF-UCL
Negative regulation of toll-like receptor signaling pathwayBy SimilarityISS:BHF-UCL
Negative regulation of tumor necrosis factor productionManual Assertion Based On ExperimentIMP:BHF-UCL
Positive regulation of cytokine productionIEA:Ensembl
Positive regulation of macrophage tolerance inductionBy SimilarityISS:BHF-UCL
Positive regulation of NF-kappaB transcription factor activityManual Assertion Based On ExperimentIMP:BHF-UCL
Protein autophosphorylationIEA:Ensembl
Protein phosphorylationManual Assertion Based On ExperimentIDA:UniProtKB
Regulation of protein-containing complex disassemblyISS:UniProtKB
Response to exogenous dsRNABy SimilarityISS:BHF-UCL
Response to interleukin-1Manual Assertion Based On ExperimentIMP:BHF-UCL
Response to lipopolysaccharideBy SimilarityISS:BHF-UCL
Response to peptidoglycanBy SimilarityISS:BHF-UCL
Response to virus1 PublicationIC:BHF-UCL

Cytoplasm; Nucleus. In dendritic cells, translocates into the nucleus upon IL33 stimulation.

Asthma-related traits 5 (ASRT5):
Asthma-related traits include clinical symptoms of asthma, such as coughing, wheezing, dyspnea, bronchial hyperresponsiveness as assessed by methacholine challenge test, serum IgE levels, atopy and atopic dermatitis.