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IRAK3 Matched Antibody Pair (643) (APMAB-643LY)


See all IRAK3 antibodies
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Specifications

ApplIcation
Sandwich ELISA
Specificity
Human
Capture Antibody
Mouse anti-IRAK3 monoclonal antibody, 100 ug
Detection Antibody
Anti-IRAK3 Rabbit polyclonal antibody, 50 ug
Dilutions
10 ng/ml-100 ng/ml
Format
Liquid
Storage
Aliquot and store at -20°Cor -80°C. Avoid freeze-thaw cycles.
Introduction
This gene encodes a member of the interleukin-1 receptor-associated kinase protein family. Members of this family are essential components of the Toll/IL-R immune signal transduction pathways. This protein is primarily expressed in monocytes and macrophages and functions as a negative regulator of Toll-like receptor signaling. Mutations in this gene are associated with a susceptibility to asthma. Alternate splicing results in multiple transcript variants. [provided by RefSeq, May 2010]
Alternative Names
Interleukin 1 Receptor Associated Kinase 3
Entrez Gene ID
11213
UniProt ID
Q9Y616
More Infomation

Nguyen, T. H., Turek, I., Meehan-Andrews, T., Zacharias, A., & Irving, H. R. (2022). A systematic review and meta-analyses of interleukin-1 receptor associated kinase 3 (IRAK3) action on inflammation in in vivo models for the study of sepsis. Plos one, 17(2), e0263968.

Nguyen, T. H., Axell, A., Turek, I., Wright, B., Meehan-Andrews, T., & Irving, H. R. (2022). Modulation of inflammatory cytokine production in human monocytes by cGMP and IRAK3. International Journal of Molecular Sciences, 23(5), 2552.

Lange, S. M., Nelen, M. I., Cohen, P., & Kulathu, Y. (2021). Dimeric structure of the pseudokinase IRAK3 suggests an allosteric mechanism for negative regulation. Structure, 29(3), 238-251.

Yu, J., Qin, Y., & Zhou, N. (2021). Knockdown of Circ_SLC39A8 protects against the progression of osteoarthritis by regulating miR-591/IRAK3 axis. Journal of orthopaedic surgery and research, 16(1), 1-10.

Leng, W., Fan, D., Ren, Z., & Li, Q. (2021). Identification of upregulated NF-κB inhibitor alpha and IRAK3 targeting lncRNA following intracranial aneurysm rupture-induced subarachnoid hemorrhage. BMC neurology, 21(1), 1-11.

Nguyen, T. H., Turek, I., Meehan-Andrews, T., Zacharias, A., & Irving, H. (2020). Analysis of interleukin-1 receptor associated kinase-3 (IRAK3) function in modulating expression of inflammatory markers in cell culture models: A systematic review and meta-analysis. Plos one, 15(12), e0244570.

Degorce, S. L., Tavana, O., Banks, E., Crafter, C., Gingipalli, L., Kouvchinov, D., ... & Edmondson, S. D. (2020). Discovery of proteolysis-targeting chimera molecules that selectively degrade the IRAK3 pseudokinase. Journal of Medicinal Chemistry, 63(18), 10460-10473.

Freihat, L. A., Wheeler, J. I., Wong, A., Turek, I., Manallack, D. T., & Irving, H. R. (2019). IRAK3 modulates downstream innate immune signalling through its guanylate cyclase activity. Scientific reports, 9(1), 15468.

Sode, J., Vogel, U., Bank, S., Andersen, P. S., Hetland, M. L., Locht, H., ... & Andersen, V. (2018). Confirmation of an IRAK3 polymorphism as a genetic marker predicting response to anti-TNF treatment in rheumatoid arthritis. The pharmacogenomics journal, 18(1), 81-86.

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For research use only. Not intended for any clinical use.

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