Itga1

This gene encodes the alpha 1 subunit of integrin receptors. This protein heterodimerizes with the beta 1 subunit to form a cell-surface receptor for collagen and laminin. The heterodimeric receptor is involved in cell-cell adhesion and may play a role in inflammation and fibrosis. The alpha 1 subunit contains an inserted (I) von Willebrand factor type I domain which is thought to be involved in collagen binding. [provided by RefSeq]
Full Name
integrin, alpha 1
Function
Integrin alpha-1/beta-1 is a receptor for laminin and collagen. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. Involved in anchorage-dependent, negative regulation of EGF-stimulated cell growth.
Biological Process
Cell-matrix adhesionManual Assertion Based On ExperimentIMP:UniProtKB
Cellular extravasationIEA:Ensembl
Integrin-mediated signaling pathwayIEA:UniProtKB-KW
Negative regulation of cell population proliferationManual Assertion Based On ExperimentIMP:UniProtKB
Negative regulation of epidermal growth factor receptor signaling pathwayISS:UniProtKB
Neuron projection morphogenesisIEA:Ensembl
Neutrophil chemotaxisIEA:Ensembl
Positive regulation of MAPK cascadeIEA:Ensembl
Positive regulation of neuron apoptotic processIEA:Ensembl
Positive regulation of phosphoprotein phosphatase activityManual Assertion Based On ExperimentIDA:UniProtKB
VasodilationIEA:Ensembl
Cellular Location
Membrane
Topology
Extracellular: 29-1141
Helical: 1142-1164
Cytoplasmic: 1165-1179
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Anti-Itga1 antibodies

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Mouse Anti-ITGA1 Recombinant Antibody (TS2/7) (CBMAB-C2079-CQ)

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Target: ITGA1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: TS2/7
Application*: F
Datasheet SDS

Mouse Anti-ITGA1 Recombinant Antibody (CBYY-I1037) (CBMAB-I2205-YY)

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Target: ITGA1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBYY-I1037
Application*: IF, BL, N
Datasheet SDS

Mouse Anti-ITGA1 Recombinant Antibody (CBYY-I0699) (CBMAB-I1535-YY)

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Target: ITGA1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-I0699
Application*: E, IP, IH, F
Datasheet SDS

Mouse Anti-ITGA1 Recombinant Antibody (CBYY-I0685) (CBMAB-I1511-YY)

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Target: ITGA1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-I0685
Application*: WB
Datasheet SDS

Mouse Anti-ITGA1 Recombinant Antibody (4G11) (CBMAB-I1346-YY)

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Target: ITGA1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 4G11
Application*: E, WB
Datasheet SDS

Rabbit Anti-ITGA1 Recombinant Antibody (1090A) (CBMAB-I0717-YY)

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Target: ITGA1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: 1090A
Application*: F
Datasheet SDS

Mouse Anti-ITGA1 Recombinant Antibody (CBT2569) (V2LY-0625-LY1784)

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Target: ITGA1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT2569
Application*: IH, F
Datasheet SDS

Mouse Anti-ITGA1 Recombinant Antibody (CBT2639) (V2LY-0625-LY1783)

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Target: ITGA1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBT2639
Application*: IH, IC, F
Datasheet SDS

Mouse Anti-ITGA1 Recombinant Antibody (1B7) (CBMAB-0477-LY)

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Target: ITGA1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Rat
Clone: 1B7
Application*: IF, WB, IH
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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