Itga1

This gene encodes the alpha 1 subunit of integrin receptors. This protein heterodimerizes with the beta 1 subunit to form a cell-surface receptor for collagen and laminin. The heterodimeric receptor is involved in cell-cell adhesion and may play a role in inflammation and fibrosis. The alpha 1 subunit contains an inserted (I) von Willebrand factor type I domain which is thought to be involved in collagen binding. [provided by RefSeq]

integrin, alpha 1

Integrin alpha-1/beta-1 is a receptor for laminin and collagen. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. Involved in anchorage-dependent, negative regulation of EGF-stimulated cell growth.

Cell-matrix adhesionManual Assertion Based On ExperimentIMP:UniProtKB
Cellular extravasationIEA:Ensembl
Integrin-mediated signaling pathwayIEA:UniProtKB-KW
Negative regulation of cell population proliferationManual Assertion Based On ExperimentIMP:UniProtKB
Negative regulation of epidermal growth factor receptor signaling pathwayISS:UniProtKB
Neuron projection morphogenesisIEA:Ensembl
Neutrophil chemotaxisIEA:Ensembl
Positive regulation of MAPK cascadeIEA:Ensembl
Positive regulation of neuron apoptotic processIEA:Ensembl
Positive regulation of phosphoprotein phosphatase activityManual Assertion Based On ExperimentIDA:UniProtKB
VasodilationIEA:Ensembl

Membrane

Extracellular: 29-1141
Helical: 1142-1164
Cytoplasmic: 1165-1179