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Mouse Anti-ITGA1 Recombinant Antibody (TS2/7) (CBMAB-C2079-CQ)

This product is a mouse antibody that recognizes ITGA1. The antibody TS2/7 can be used for immunoassay techniques such as: FC.
See all ITGA1 antibodies
Published Data
Fig.1 Integrin expression in E4+ECs, APOCC and Skov3. PCR for integrins α1 was performed.
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Summary

Host Animal
Mouse
Specificity
Human
Clone
TS2/7
Antibody Isotype
IgG1
Application
FC

Basic Information

Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
Buffer containing stabilizer
Preservative
0.05% sodium azide
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
integrin, alpha 1
Introduction
This gene encodes the alpha 1 subunit of integrin receptors. This protein heterodimerizes with the beta 1 subunit to form a cell-surface receptor for collagen and laminin. The heterodimeric receptor is involved in cell-cell adhesion and may play a role in inflammation and fibrosis. The alpha 1 subunit contains an inserted (I) von Willebrand factor type I domain which is thought to be involved in collagen binding.
Entrez Gene ID
3672
UniProt ID
P56199
Alternative Names
Integrin Subunit Alpha 1
Function
Integrin alpha-1/beta-1 is a receptor for laminin and collagen. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. Involved in anchorage-dependent, negative regulation of EGF-stimulated cell growth.
Biological Process
Cell-matrix adhesionManual Assertion Based On ExperimentIMP:UniProtKB
Cellular extravasationIEA:Ensembl
Integrin-mediated signaling pathwayIEA:UniProtKB-KW
Negative regulation of cell population proliferationManual Assertion Based On ExperimentIMP:UniProtKB
Negative regulation of epidermal growth factor receptor signaling pathwayISS:UniProtKB
Neuron projection morphogenesisIEA:Ensembl
Neutrophil chemotaxisIEA:Ensembl
Positive regulation of MAPK cascadeIEA:Ensembl
Positive regulation of neuron apoptotic processIEA:Ensembl
Positive regulation of phosphoprotein phosphatase activityManual Assertion Based On ExperimentIDA:UniProtKB
VasodilationIEA:Ensembl
Cellular Location
Membrane
Topology
Extracellular: 29-1141
Helical: 1142-1164
Cytoplasmic: 1165-1179

St Amant, J., Michaud, J., Hinds, D., Coyle, M., Pozzi, A., & Clark, A. L. (2023). Depleting transforming growth factor beta receptor 2 signalling in the cartilage of itga1-null mice attenuates spontaneous knee osteoarthritis. Osteoarthritis and Cartilage Open, 5(4), 100399.

Zhang, S., Lai, T., Su, X., Zhang, Y., Zhou, J., Zhao, C., ... & Hu, H. (2023). Linc00662 m6A promotes the progression and metastasis of pancreatic cancer by activating focal adhesion through the GTF2B-ITGA1-FAK pathway. American Journal of Cancer Research, 13(5), 1718.

Li, X., Wang, N., Leng, H., Yuan, H., & Xu, L. (2022). Hsa_circ_0043949 reinforces temozolomide resistance via upregulating oncogene ITGA1 axis in glioblastoma. Metabolic Brain Disease, 37(8), 2979-2993.

Radmanić, L., Korać, P., Gorenec, L., Šimičić, P., Bodulić, K., Vince, A., & Lepej, S. Ž. (2022). Distinct Expression Patterns of Genes Coding for Biological Response Modifiers Involved in Inflammatory Responses and Development of Fibrosis in Chronic Hepatitis C: Upregulation of SMAD-6 and MMP-8 and Downregulation of CAV-1, CTGF, CEBPB, PLG, TIMP-3, MMP-1, ITGA-1, ITGA-2 and LOX. Medicina, 58(12), 1734.

Li, H., Liu, Q., Chen, Z., Wu, M., Zhang, C., Su, J., ... & Zhang, C. (2021). Hsa_circ_0110757 upregulates ITGA1 to facilitate temozolomide resistance in glioma by suppressing hsa-miR-1298-5p. Cell Death & Disease, 12(3), 252.

Gu, C., Zhang, H., & Gao, Y. (2021). Adipose mesenchymal stem cells‐secreted extracellular vesicles containing microRNA‐192 delays diabetic retinopathy by targeting ITGA1. Journal of cellular physiology, 236(7), 5036-5051.

Liu, L., Liu, H., Luo, S., Patz Jr, E. F., Glass, C., Su, L., ... & Wei, Q. (2020). Novel genetic variants of SYK and ITGA1 related lymphangiogenesis signaling pathway predict non-small cell lung cancer survival. American journal of cancer research, 10(8), 2603.

Ma, Q., Song, J., Ma, H., Gao, K., Yang, Y., & He, N. (2019). Synergistic anticancer effect of Grb2 and ITGA1 on cancer cells highly expressing Grb2 through suppressing ERK phosphorylation. International Journal of Clinical and Experimental Pathology, 12(1), 182.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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