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Mouse Anti-ITGA1 Recombinant Antibody (1B7) (CBMAB-0477-LY)

This product is mouse antibody recognizes ITGA1 of rat. The antibody 1B7 immunoassay techniques such as: IF, WB, IHC.
See all ITGA1 antibodies

Summary

Host Animal
Mouse
Specificity
Rat
Clone
1B7
Antibody Isotype
IgG1
Application
IF, WB, IHC

Basic Information

Specificity
Rat
Antibody Isotype
IgG1
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
integrin, alpha 1
Entrez Gene ID
25118
UniProt ID
P18614
Function
Integrin alpha-1/beta-1 is a receptor for laminin and collagen. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. Involved in anchorage-dependent, negative regulation of EGF-stimulated cell growth.
Biological Process
Cell-matrix adhesionManual Assertion Based On ExperimentIMP:UniProtKB
Cellular extravasationIEA:Ensembl
Integrin-mediated signaling pathwayIEA:UniProtKB-KW
Negative regulation of cell population proliferationManual Assertion Based On ExperimentIMP:UniProtKB
Negative regulation of epidermal growth factor receptor signaling pathwayISS:UniProtKB
Neuron projection morphogenesisIEA:Ensembl
Neutrophil chemotaxisIEA:Ensembl
Positive regulation of MAPK cascadeIEA:Ensembl
Positive regulation of neuron apoptotic processIEA:Ensembl
Positive regulation of phosphoprotein phosphatase activityManual Assertion Based On ExperimentIDA:UniProtKB
VasodilationIEA:Ensembl
Cellular Location
Membrane
Topology
Extracellular: 29-1141
Helical: 1142-1164
Cytoplasmic: 1165-1179

St Amant, J., Michaud, J., Hinds, D., Coyle, M., Pozzi, A., & Clark, A. L. (2023). Depleting transforming growth factor beta receptor 2 signalling in the cartilage of itga1-null mice attenuates spontaneous knee osteoarthritis. Osteoarthritis and Cartilage Open, 5(4), 100399.

Zhang, S., Lai, T., Su, X., Zhang, Y., Zhou, J., Zhao, C., ... & Hu, H. (2023). Linc00662 m6A promotes the progression and metastasis of pancreatic cancer by activating focal adhesion through the GTF2B-ITGA1-FAK pathway. American Journal of Cancer Research, 13(5), 1718.

Li, X., Wang, N., Leng, H., Yuan, H., & Xu, L. (2022). Hsa_circ_0043949 reinforces temozolomide resistance via upregulating oncogene ITGA1 axis in glioblastoma. Metabolic Brain Disease, 37(8), 2979-2993.

Radmanić, L., Korać, P., Gorenec, L., Šimičić, P., Bodulić, K., Vince, A., & Lepej, S. Ž. (2022). Distinct Expression Patterns of Genes Coding for Biological Response Modifiers Involved in Inflammatory Responses and Development of Fibrosis in Chronic Hepatitis C: Upregulation of SMAD-6 and MMP-8 and Downregulation of CAV-1, CTGF, CEBPB, PLG, TIMP-3, MMP-1, ITGA-1, ITGA-2 and LOX. Medicina, 58(12), 1734.

Li, H., Liu, Q., Chen, Z., Wu, M., Zhang, C., Su, J., ... & Zhang, C. (2021). Hsa_circ_0110757 upregulates ITGA1 to facilitate temozolomide resistance in glioma by suppressing hsa-miR-1298-5p. Cell Death & Disease, 12(3), 252.

Gu, C., Zhang, H., & Gao, Y. (2021). Adipose mesenchymal stem cells‐secreted extracellular vesicles containing microRNA‐192 delays diabetic retinopathy by targeting ITGA1. Journal of cellular physiology, 236(7), 5036-5051.

Liu, L., Liu, H., Luo, S., Patz Jr, E. F., Glass, C., Su, L., ... & Wei, Q. (2020). Novel genetic variants of SYK and ITGA1 related lymphangiogenesis signaling pathway predict non-small cell lung cancer survival. American journal of cancer research, 10(8), 2603.

Ma, Q., Song, J., Ma, H., Gao, K., Yang, Y., & He, N. (2019). Synergistic anticancer effect of Grb2 and ITGA1 on cancer cells highly expressing Grb2 through suppressing ERK phosphorylation. International Journal of Clinical and Experimental Pathology, 12(1), 182.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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