KIF16B

The protein encoded by this gene is a kinesin-like protein that may be involved in intracellular trafficking. Three transcript variants encoding different isoforms have been found for this gene.

Full Name

kinesin family member 16B

Function

Plus end-directed microtubule-dependent motor protein involved in endosome transport and receptor recycling and degradation. Regulates the plus end motility of early endosomes and the balance between recycling and degradation of receptors such as EGF receptor (EGFR) and FGF receptor (FGFR). Regulates the Golgi to endosome transport of FGFR-containing vesicles during early development, a key process for developing basement membrane and epiblast and primitive endoderm lineages during early postimplantation development.

Biological Process

Early endosome to late endosome transportManual Assertion Based On ExperimentIMP:UniProtKB
Endoderm developmentISS:UniProtKB
Epidermal growth factor receptor signaling pathwayManual Assertion Based On ExperimentIMP:UniProtKB
Fibroblast growth factor receptor signaling pathwayISS:UniProtKB
Formation of primary germ layerISS:UniProtKB
Golgi to endosome transportISS:UniProtKB
Microtubule-based movementManual Assertion Based On ExperimentIBA:GO_Central
Receptor catabolic processManual Assertion Based On ExperimentIMP:UniProtKB
Regulation of receptor recyclingManual Assertion Based On ExperimentIMP:UniProtKB

Cellular Location

Cytoplasm, cytoskeleton; Early endosome membrane; Cytoplasm; Cytoplasm, cytoskeleton, spindle. It is unclear whether association with endosomes is mediated via phosphatidylinositol 3-phosphate (PtdIns(3)P)-binding or via its interaction with RAB14.