Mouse Anti-KIF16B Recombinant Antibody (2B5) (CBMAB-K0846-LY)

Name: Mouse Anti-KIF16B Recombinant Antibody (2B5)
SKU: CBMAB-K0846-LY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

2B5

Application

ELISA, WB

Immunogen

KIF16B (AAH34984, 65 a.a. ~ 174 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.Immunogen sequence: DDLKDPIKIS IPRYVLCGQG KDAHFEFEVK LAALEFPPKK LFGNKDERVI AERRSHLEKY LRDFFSVMLQ SATSPLHINK VGLTLSKHTI CEFSPFFKKG VFDYSSHGTG

Specificity

Human

Antibody Isotype

IgG2a, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

kinesin family member 16B

Introduction

The protein encoded by this gene is a kinesin-like protein that may be involved in intracellular trafficking. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2010]

Entrez Gene ID

55614

UniProt ID

Q96L93

Alternative Names

Kinesin Family Member 16B; C20orf23; SNX23; Testis Secretory Sperm-Binding Protein Li 201a; Chromosome 20 Open Reading Frame 23; Kinesin-Like Protein KIF16B;

Function

Plus end-directed microtubule-dependent motor protein involved in endosome transport and receptor recycling and degradation. Regulates the plus end motility of early endosomes and the balance between recycling and degradation of receptors such as EGF receptor (EGFR) and FGF receptor (FGFR). Regulates the Golgi to endosome transport of FGFR-containing vesicles during early development, a key process for developing basement membrane and epiblast and primitive endoderm lineages during early postimplantation development.

Biological Process

Early endosome to late endosome transportManual Assertion Based On ExperimentIMP:UniProtKB
Endoderm developmentISS:UniProtKB
Epidermal growth factor receptor signaling pathwayManual Assertion Based On ExperimentIMP:UniProtKB
Fibroblast growth factor receptor signaling pathwayISS:UniProtKB
Formation of primary germ layerISS:UniProtKB
Golgi to endosome transportISS:UniProtKB
Microtubule-based movementManual Assertion Based On ExperimentIBA:GO_Central
Receptor catabolic processManual Assertion Based On ExperimentIMP:UniProtKB
Regulation of receptor recyclingManual Assertion Based On ExperimentIMP:UniProtKB

Cellular Location

Cytoplasm, cytoskeleton; Early endosome membrane; Cytoplasm; Cytoplasm, cytoskeleton, spindle. It is unclear whether association with endosomes is mediated via phosphatidylinositol 3-phosphate (PtdIns(3)P)-binding or via its interaction with RAB14.

Li, B. J., Chen, H., Jiang, S. S., Wang, C. Y., Tuo, Q. H., Long, S. Y., ... & Liao, D. F. (2020). PX domain-containing kinesin KIF16B and microtubule-dependent intracellular movements. The Journal of Membrane Biology, 253, 101-108.

Alsahli, S., Arold, S. T., Alfares, A., Alhaddad, B., Al Balwi, M., Kamsteeg, E. J., ... & Alfadhel, M. (2018). KIF16B is a candidate gene for a novel autosomal‐recessive intellectual disability syndrome. American Journal of Medical Genetics Part A, 176(7), 1602-1609.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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