KIFAP3

The small G protein GDP dissociation stimulator (smg GDS) is a regulator protein having two activities on a group of small G proteins including the Rho and Rap1 family members and Ki-Ras; one is to stimulate their GDP/GTP exchange reactions, and the other is to inhibit their interactions with membranes. The protein encoded by this gene contains 9 'Armadillo' repeats and interacts with the smg GDS protein through these repeats. This protein, which is highly concentrated around the endoplasmic reticulum, is phosphorylated by v-src, and this phosphorylation reduces the affinity of the protein for smg GDS. It is thought that this protein serves as a linker between human chromosome-associated polypeptide (HCAP) and KIF3A/B, a kinesin superfamily protein in the nucleus, and that it plays a role in the interaction of chromosomes with an ATPase motor protein. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2011]

Full Name

Kinesin Associated Protein 3

Function

Involved in tethering the chromosomes to the spindle pole and in chromosome movement. Binds to the tail domain of the KIF3A/KIF3B heterodimer to form a heterotrimeric KIF3 complex and may regulate the membrane binding of this complex (By similarity).

Biological Process

Cilium organizationManual Assertion Based On ExperimentIBA:GO_Central
Microtubule-based movementManual Assertion Based On ExperimentIBA:GO_Central
Microtubule-based processISS:UniProtKB
Negative regulation of apoptotic processIEA:Ensembl
Negative regulation of cell population proliferationIEA:Ensembl
Plus-end-directed vesicle transport along microtubuleManual Assertion Based On ExperimentTAS:BHF-UCL
Positive regulation of calcium-dependent cell-cell adhesionIEA:Ensembl
Protein localizationIEA:Ensembl
Protein-containing complex assemblyManual Assertion Based On ExperimentTAS:ProtInc
Signal transductionManual Assertion Based On ExperimentTAS:ProtInc

Cellular Location

Axoneme; Centrosome; Ciliary basal body; Ciliary tip; Ciliary transition zone; Cilium; Condensed nuclear chromosome; Cytosol; Endoplasmic reticulum; Golgi apparatus; Microtubule cytoskeleton

PTM

Phosphorylated on tyrosine residues by SRC in vitro; this reduces the binding affinity of the protein for RAP1GDS1.