Sign in or Register   Sign in or Register
  |  

Rabbit Anti-KIFAP3 Recombinant Antibody (CBLY1-091) (CBMAB-K0899-LY)

This product is antibody recognizes KIFAP3. The antibody CBLY1-091 immunoassay techniques such as: WB, IHC-P, ICC.
See all KIFAP3 antibodies

Summary

Host Animal
Rabbit
Specificity
Mouse, Rat, Human
Clone
CBLY1-091
Antibody Isotype
IgG
Application
WB, IHC-P, ICC

Basic Information

Specificity
Mouse, Rat, Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Kinesin Associated Protein 3
Introduction
The small G protein GDP dissociation stimulator (smg GDS) is a regulator protein having two activities on a group of small G proteins including the Rho and Rap1 family members and Ki-Ras; one is to stimulate their GDP/GTP exchange reactions, and the other is to inhibit their interactions with membranes. The protein encoded by this gene contains 9 'Armadillo' repeats and interacts with the smg GDS protein through these repeats. This protein, which is highly concentrated around the endoplasmic reticulum, is phosphorylated by v-src, and this phosphorylation reduces the affinity of the protein for smg GDS. It is thought that this protein serves as a linker between human chromosome-associated polypeptide (HCAP) and KIF3A/B, a kinesin superfamily protein in the nucleus, and that it plays a role in the interaction of chromosomes with an ATPase motor protein. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2011]
Entrez Gene ID
Human22920
Mouse16579
Rat289168
UniProt ID
HumanQ92845
MouseP70188
RatD3ZWA5
Function
Involved in tethering the chromosomes to the spindle pole and in chromosome movement. Binds to the tail domain of the KIF3A/KIF3B heterodimer to form a heterotrimeric KIF3 complex and may regulate the membrane binding of this complex (By similarity).
Biological Process
Cilium organizationManual Assertion Based On ExperimentIBA:GO_Central
Microtubule-based movementManual Assertion Based On ExperimentIBA:GO_Central
Microtubule-based processISS:UniProtKB
Negative regulation of apoptotic processIEA:Ensembl
Negative regulation of cell population proliferationIEA:Ensembl
Plus-end-directed vesicle transport along microtubuleManual Assertion Based On ExperimentTAS:BHF-UCL
Positive regulation of calcium-dependent cell-cell adhesionIEA:Ensembl
Protein localizationIEA:Ensembl
Protein-containing complex assemblyManual Assertion Based On ExperimentTAS:ProtInc
Signal transductionManual Assertion Based On ExperimentTAS:ProtInc
Cellular Location
Axoneme; Centrosome; Ciliary basal body; Ciliary tip; Ciliary transition zone; Cilium; Condensed nuclear chromosome; Cytosol; Endoplasmic reticulum; Golgi apparatus; Microtubule cytoskeleton
PTM
Phosphorylated on tyrosine residues by SRC in vitro; this reduces the binding affinity of the protein for RAP1GDS1.
Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Rabbit Anti-KIFAP3 Recombinant Antibody (CBLY1-091)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Documents

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Go to
Compare