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KRT2

The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is expressed largely in the upper spinous layer of epidermal keratinocytes and mutations in this gene have been associated with bullous congenital ichthyosiform erythroderma. The type II cytokeratins are clustered in a region of chromosome 12q12-q13. [provided by RefSeq, Jul 2008]
Full Name
Keratin 2
Function
Probably contributes to terminal cornification (PubMed:1380918).
Associated with keratinocyte activation, proliferation and keratinization (PubMed:12598329).
Plays a role in the establishment of the epidermal barrier on plantar skin (By similarity).
Biological Process
Epidermis developmentManual Assertion Based On ExperimentTAS:ProtInc
Intermediate filament organizationIEA:Ensembl
KeratinizationManual Assertion Based On ExperimentIDA:UniProtKB
Keratinocyte activationManual Assertion Based On ExperimentIDA:UniProtKB
Keratinocyte developmentIEA:Ensembl
Keratinocyte migrationManual Assertion Based On ExperimentIDA:UniProtKB
Keratinocyte proliferationManual Assertion Based On ExperimentIDA:UniProtKB
Peptide cross-linkingManual Assertion Based On ExperimentIDA:CAFA
Positive regulation of epidermis developmentISS:UniProtKB
Cellular Location
Cornified envelope
Cytosol
Extracellular exosome
Extracellular space
Intermediate filament
Keratin filament
Membrane
Nucleus
Involvement in disease
Ichthyosis bullosa of Siemens (IBS):
A rare autosomal dominant skin disorder displaying a type of epidermolytic hyperkeratosis characterized by generalized erythema and extensive blistering from birth. Large, dark gray hyperkeratoses are observed in later weeks. The skin of IBS patients is unusually fragile and has a tendency to shed the outer layers of the epidermis, producing localized denuded areas (molting effect). IBS usually improves with age so that in most middle-aged patients the hyperkeratosis and keratotic lichenification is limited to the flexural folds of the major joints.

Anti-KRT2 antibodies

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Mouse Anti-KRT2 Recombinant Antibody (PC-26) (CBMAB-P0458-YC)

Datasheet SDS
Target: KRT2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat
Clone: PC-26
Application*: E, WB, IH

Mouse Anti-KRT2 Recombinant Antibody (Ks2.342.7.1) (CBMAB-K1811-LY)

Datasheet SDS
Target: KRT2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: Ks2.342.7.1
Application*: C, P

Mouse Anti-KRT2 Recombinant Antibody (Ks2-342-7-1) (CBMAB-K1813-LY)

Datasheet SDS
Target: KRT2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: Ks2-342-7-1
Application*: C, P, IP, WB

Mouse Anti-KRT2 Recombinant Antibody (Ks2-398-3-1) (CBMAB-K1814-LY)

Datasheet SDS
Target: KRT2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: Ks2-398-3-1
Application*: IH, WB

Mouse Anti-KRT2 Recombinant Antibody (CBWJC-4030) (CBMAB-C5355WJ)

Datasheet SDS
Target: KRT2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Mouse, Rat, Rabbit, Chicken, Cattle, Human, Pig, Monkey
Clone: CBWJC-4030
Application*: WB, P, C

Rabbit Anti-KRT2 Recombinant Antibody (CBWJC-4031) (CBMAB-C5356WJ)

Datasheet SDS
Target: KRT2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBWJC-4031
Application*: WB, P

Mouse Anti-KRT2 Recombinant Antibody (CBWJC-4032) (CBMAB-C5357WJ)

Datasheet SDS
Target: KRT2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Cattle, Human, Mouse, Rat
Clone: CBWJC-4032
Application*: C, IC, WB, P

Mouse Anti-KRT2 Recombinant Antibody (CBWJC-4033) (CBMAB-C5358WJ)

Datasheet SDS
Target: KRT2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBWJC-4033
Application*: C, WB

Mouse Anti-KRT2 Recombinant Antibody (CBWJC-4034) (CBMAB-C5360WJ)

Datasheet SDS
Target: KRT2
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human, Cattle, Amphibia
Clone: CBWJC-4034
Application*: IF, P, WB

Mouse Anti-KRT2 (N-terminus) Recombinant Antibody (CBYY-C2609) (CBMAB-C4050-YY)

Datasheet SDS
Target: KRT2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Cattle, Human, Mouse, Rat
Clone: CBYY-C2609
Application*: E, IF, IH, WB

Mouse Anti-KRT2 (N-terminus) Recombinant Antibody (CBYY-C2610) (CBMAB-C4051-YY)

Datasheet SDS
Target: KRT2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Frog
Clone: CBYY-C2610
Application*: IH, WB

Recombinant Mouse Anti-KRT2 Recombinant Antibody (LHK2E) (CBMAB-XB0715-YC)

Datasheet SDS
Target: KRT2
Host: Mouse
Antibody Isotype: IgM
Specificity: Human
Clone: LHK2E
Application*: IH, WB

Mouse Anti-KRT2 Recombinant Antibody (Ks pan1-8) (CBMAB-K0211-LY)

Datasheet SDS
Target: KRT2
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human, Cattle, Amphibia
Clone: Ks pan1-8
Application*: IF, F

Mouse Anti-KRT2 Recombinant Antibody (16k92) (CBMAB-C3396-LY)

Datasheet SDS
Target: KRT2
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: 16k92
Application*: IF, C, WB

Mouse Anti-KRT2 Recombinant Antibody (5D49) (CBMAB-C7462-LY)

Datasheet SDS
Target: KRT2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Cattle, Mouse, Rat
Clone: 5D49
Application*: E, IF, C, WB

Mouse Anti-KRT2 Recombinant Antibody (5F232) (CBMAB-C7580-LY)

Datasheet SDS
Target: KRT2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Frog
Clone: 5F232
Application*: C, WB
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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