KRT2

The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is expressed largely in the upper spinous layer of epidermal keratinocytes and mutations in this gene have been associated with bullous congenital ichthyosiform erythroderma. The type II cytokeratins are clustered in a region of chromosome 12q12-q13. [provided by RefSeq, Jul 2008]
Full Name
Keratin 2
Function
Probably contributes to terminal cornification (PubMed:1380918).
Associated with keratinocyte activation, proliferation and keratinization (PubMed:12598329).
Plays a role in the establishment of the epidermal barrier on plantar skin (By similarity).
Biological Process
Epidermis developmentManual Assertion Based On ExperimentTAS:ProtInc
Intermediate filament organizationIEA:Ensembl
KeratinizationManual Assertion Based On ExperimentIDA:UniProtKB
Keratinocyte activationManual Assertion Based On ExperimentIDA:UniProtKB
Keratinocyte developmentIEA:Ensembl
Keratinocyte migrationManual Assertion Based On ExperimentIDA:UniProtKB
Keratinocyte proliferationManual Assertion Based On ExperimentIDA:UniProtKB
Peptide cross-linkingManual Assertion Based On ExperimentIDA:CAFA
Positive regulation of epidermis developmentISS:UniProtKB
Cellular Location
Cornified envelope
Cytosol
Extracellular exosome
Extracellular space
Intermediate filament
Keratin filament
Membrane
Nucleus
Involvement in disease
Ichthyosis bullosa of Siemens (IBS):
A rare autosomal dominant skin disorder displaying a type of epidermolytic hyperkeratosis characterized by generalized erythema and extensive blistering from birth. Large, dark gray hyperkeratoses are observed in later weeks. The skin of IBS patients is unusually fragile and has a tendency to shed the outer layers of the epidermis, producing localized denuded areas (molting effect). IBS usually improves with age so that in most middle-aged patients the hyperkeratosis and keratotic lichenification is limited to the flexural folds of the major joints.
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Anti-KRT2 antibodies

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Mouse Anti-KRT2 Recombinant Antibody (16k92) (CBMAB-C3396-LY)

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Target: KRT2
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: 16k92
Application*: IF, C, WB
Datasheet SDS

Recombinant Mouse Anti-KRT2 Recombinant Antibody (LHK2E) (CBMAB-XB0715-YC)

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Target: KRT2
Host: Mouse
Antibody Isotype: IgM
Specificity: Human
Clone: LHK2E
Application*: IH, WB
Datasheet SDS

Mouse Anti-KRT2 Recombinant Antibody (PC-26) (CBMAB-P0458-YC)

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Target: KRT2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat
Clone: PC-26
Application*: E, WB, IH
Datasheet SDS

Mouse Anti-KRT2 (N-terminus) Recombinant Antibody (CBYY-C2610) (CBMAB-C4051-YY)

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Target: KRT2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Frog
Clone: CBYY-C2610
Application*: IH, WB
Datasheet SDS

Mouse Anti-KRT2 (N-terminus) Recombinant Antibody (CBYY-C2609) (CBMAB-C4050-YY)

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Target: KRT2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Cattle, Human, Mouse, Rat
Clone: CBYY-C2609
Application*: E, IF, IH, WB
Datasheet SDS

Mouse Anti-KRT2 Recombinant Antibody (5F232) (CBMAB-C7580-LY)

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Target: KRT2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Frog
Clone: 5F232
Application*: C, WB
Datasheet SDS

Mouse Anti-KRT2 Recombinant Antibody (5D49) (CBMAB-C7462-LY)

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Target: KRT2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Cattle, Mouse, Rat
Clone: 5D49
Application*: E, IF, C, WB
Datasheet SDS

Mouse Anti-KRT2 Recombinant Antibody (Ks2-398-3-1) (CBMAB-K1814-LY)

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Target: KRT2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: Ks2-398-3-1
Application*: IH, WB
Datasheet SDS

Mouse Anti-KRT2 Recombinant Antibody (Ks2-342-7-1) (CBMAB-K1813-LY)

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Target: KRT2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: Ks2-342-7-1
Application*: C, P, IP, WB
Datasheet SDS

Mouse Anti-KRT2 Recombinant Antibody (Ks2.342.7.1) (CBMAB-K1811-LY)

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Target: KRT2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: Ks2.342.7.1
Application*: C, P
Datasheet SDS

Mouse Anti-KRT2 Recombinant Antibody (Ks pan1-8) (CBMAB-K0211-LY)

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Target: KRT2
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human, Cattle, Amphibia
Clone: Ks pan1-8
Application*: IF, F
Datasheet SDS

Mouse Anti-KRT2 Recombinant Antibody (CBT4416) (V2LY-0625-LY1632)

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Target: KRT2
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBT4416
Application*: WB, IH, IC, F
Datasheet SDS

Mouse Anti-KRT2 Recombinant Antibody (CBT2205) (V2LY-0625-LY1631)

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Target: KRT2
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBT2205
Application*: IH, IC
Datasheet SDS

Mouse Anti-KRT2 Recombinant Antibody (CBWJC-4034) (CBMAB-C5360WJ)

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Target: KRT2
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human, Cattle, Amphibia
Clone: CBWJC-4034
Application*: IF, P, WB
Datasheet SDS

Mouse Anti-KRT2 Recombinant Antibody (CBWJC-4033) (CBMAB-C5358WJ)

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Target: KRT2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBWJC-4033
Application*: C, WB
Datasheet SDS

Mouse Anti-KRT2 Recombinant Antibody (CBWJC-4032) (CBMAB-C5357WJ)

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Target: KRT2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Cattle, Human, Mouse, Rat
Clone: CBWJC-4032
Application*: C, IC, WB, P
Datasheet SDS

Rabbit Anti-KRT2 Recombinant Antibody (CBWJC-4031) (CBMAB-C5356WJ)

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Target: KRT2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBWJC-4031
Application*: WB, P
Datasheet SDS

Mouse Anti-KRT2 Recombinant Antibody (CBWJC-4030) (CBMAB-C5355WJ)

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Target: KRT2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Mouse, Rat, Rabbit, Chicken, Cattle, Human, Pig, Monkey
Clone: CBWJC-4030
Application*: WB, P, C
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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