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Mouse Anti-KRT2 Recombinant Antibody (Ks2-342-7-1) (CBMAB-K1813-LY)

This product is antibody recognizes KRT2. The antibody Ks2-342-7-1 immunoassay techniques such as: IHC-Fr, IHC-P, IP, WB.
See all KRT2 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
Ks2-342-7-1
Antibody Isotype
IgG1
Application
IHC-Fr, IHC-P, IP, WB

Basic Information

Immunogen
Basic human keratin K2
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Keratin 2
Introduction
The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is expressed largely in the upper spinous layer of epidermal keratinocytes and mutations in this gene have been associated with bullous congenital ichthyosiform erythroderma. The type II cytokeratins are clustered in a region of chromosome 12q12-q13. [provided by RefSeq, Jul 2008]
Entrez Gene ID
3849
UniProt ID
P35908
Alternative Names
Keratin 2; Epithelial Keratin-2e; Keratin-2 Epidermis; Type-II Keratin Kb2; Keratin 2; Type II; Cytokeratin-2e; Keratin-2e; KRT2A;
Function
Probably contributes to terminal cornification (PubMed:1380918).
Associated with keratinocyte activation, proliferation and keratinization (PubMed:12598329).
Plays a role in the establishment of the epidermal barrier on plantar skin (By similarity).
Biological Process
Epidermis developmentManual Assertion Based On ExperimentTAS:ProtInc
Intermediate filament organizationIEA:Ensembl
KeratinizationManual Assertion Based On ExperimentIDA:UniProtKB
Keratinocyte activationManual Assertion Based On ExperimentIDA:UniProtKB
Keratinocyte developmentIEA:Ensembl
Keratinocyte migrationManual Assertion Based On ExperimentIDA:UniProtKB
Keratinocyte proliferationManual Assertion Based On ExperimentIDA:UniProtKB
Peptide cross-linkingManual Assertion Based On ExperimentIDA:CAFA
Positive regulation of epidermis developmentISS:UniProtKB
Cellular Location
Cornified envelope
Cytosol
Extracellular exosome
Extracellular space
Intermediate filament
Keratin filament
Membrane
Nucleus
Involvement in disease
Ichthyosis bullosa of Siemens (IBS):
A rare autosomal dominant skin disorder displaying a type of epidermolytic hyperkeratosis characterized by generalized erythema and extensive blistering from birth. Large, dark gray hyperkeratoses are observed in later weeks. The skin of IBS patients is unusually fragile and has a tendency to shed the outer layers of the epidermis, producing localized denuded areas (molting effect). IBS usually improves with age so that in most middle-aged patients the hyperkeratosis and keratotic lichenification is limited to the flexural folds of the major joints.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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