Mouse Anti-KRT2 Recombinant Antibody (CBT2205) (V2LY-0625-LY1631)

Name: Mouse Anti-KRT2 Recombinant Antibody (CBT2205)
SKU: V2LY-0625-LY1631
Rating: 5 (1 reviews)

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Tested Data

Mouse Anti-KRT2 Recombinant Antibody (CBT2205) (V2LY-0625-LY1631) in ELISA

Mouse Anti-KRT2 Recombinant Antibody (CBT2205) (V2LY-0625-LY1631) in WB

Mouse Anti-KRT2 Recombinant Antibody (CBT2205) (V2LY-0625-LY1631) in IF

Mouse Anti-KRT2 Recombinant Antibody (CBT2205) (V2LY-0625-LY1631) in IHC

Datasheet

Summary

Host Animal

Mouse

Specificity

Human

Clone

CBT2205

Antibody Isotype

IgG2a

Application

IHC, ICC

Basic Information

Immunogen

Purified recombinant fragment of human KRT2 (AA: 177-490) expressed in E. Coli.

Host Species

Mouse

Specificity

Human

Antibody Isotype

IgG2a

Clonality

Monoclonal Antibody

Application Notes

Application	Note
WB	1:500-1:2,000
IHC-P	1:200-1:1,000
ICC	1:200-1:1,000
ELISA	1:10,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS

Preservative

Sodium azide

Concentration

Batch dependent

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Entrez Gene ID

3849

UniProt ID

P35908

Function

Probably contributes to terminal cornification (PubMed:1380918).
Associated with keratinocyte activation, proliferation and keratinization (PubMed:12598329).
Plays a role in the establishment of the epidermal barrier on plantar skin (By similarity).

Biological Process

Epidermis developmentManual Assertion Based On ExperimentTAS:ProtInc
Intermediate filament organizationIEA:Ensembl
KeratinizationManual Assertion Based On ExperimentIDA:UniProtKB
Keratinocyte activationManual Assertion Based On ExperimentIDA:UniProtKB
Keratinocyte developmentIEA:Ensembl
Keratinocyte migrationManual Assertion Based On ExperimentIDA:UniProtKB
Keratinocyte proliferationManual Assertion Based On ExperimentIDA:UniProtKB
Peptide cross-linkingManual Assertion Based On ExperimentIDA:CAFA
Positive regulation of epidermis developmentISS:UniProtKB

Cellular Location

Cornified envelope
Cytosol
Extracellular exosome
Extracellular space
Intermediate filament
Keratin filament
Membrane
Nucleus

Involvement in disease

Ichthyosis bullosa of Siemens (IBS):
A rare autosomal dominant skin disorder displaying a type of epidermolytic hyperkeratosis characterized by generalized erythema and extensive blistering from birth. Large, dark gray hyperkeratoses are observed in later weeks. The skin of IBS patients is unusually fragile and has a tendency to shed the outer layers of the epidermis, producing localized denuded areas (molting effect). IBS usually improves with age so that in most middle-aged patients the hyperkeratosis and keratotic lichenification is limited to the flexural folds of the major joints.

More Infomation

References

Frommherz, L., Komlosi, K., Hewel, C., Kopp, J., Dewenter, M., Zimmer, A., ... & Has, C. (2023). Acral lamellar ichthyosis with amino acid substitution in the C‐terminus of keratin 2. Journal of the European Academy of Dermatology and Venereology, 37(4), 817-822.

Suzuki, Y., Takeichi, T., Tanahashi, K., Muro, Y., Suga, Y., Ogi, T., & Akiyama, M. (2022). Deep phenotyping of superficial Epidermolytic ichthyosis due to a recurrent mutation in KRT2. International Journal of Molecular Sciences, 23(14), 7791.

Diociaiuti, A., Castiglia, D., Corbeddu, M., Rotunno, R., Rossi, S., Pisaneschi, E., ... & El Hachem, M. (2020). First case of KRT2 epidermolytic nevus and novel clinical and genetic findings in 26 Italian patients with keratinopathic ichthyoses. International Journal of Molecular Sciences, 21(20), 7707.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Associated Products

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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Documents

Datasheet
SDS
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Second antibody and isotype control

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