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KSR2

Location-regulated scaffold connecting MEK to RAF. Has very low protein kinase activity and can phosphorylate MAP2K1 at several Ser and Thr residues with very low efficiency (in vitro). Interaction with BRAF enhances KSR2-mediated phosphorylation of MAP2K1 (in vitro). Blocks MAP3K8 kinase activity and MAP3K8-mediated signaling. Acts as a negative regulator of MAP3K3-mediated activation of ERK, JNK and NF-kappa-B pathways, inhibiting MAP3K3-mediated interleukin-8 production.

Full Name

kinase suppressor of ras 2

Function

Location-regulated scaffold connecting MEK to RAF. Has very low protein kinase activity and can phosphorylate MAP2K1 at several Ser and Thr residues with very low efficiency (in vitro). Acts as MAP2K1/MEK1-dependent allosteric activator of BRAF; upon binding to MAP2K1/MEK1, dimerizes with BRAF and promotes BRAF-mediated phosphorylation of MAP2K1/MEK1 (PubMed:29433126).
Interaction with BRAF enhances KSR2-mediated phosphorylation of MAP2K1 (in vitro). Blocks MAP3K8 kinase activity and MAP3K8-mediated signaling. Acts as a negative regulator of MAP3K3-mediated activation of ERK, JNK and NF-kappa-B pathways, inhibiting MAP3K3-mediated interleukin-8 production.

Biological Process

Calcium-mediated signalingManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of cold-induced thermogenesisBy SimilarityISS:YuBioLab
Ras protein signal transductionManual Assertion Based On ExperimentIBA:GO_Central
Signal transductionManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

Cytoplasm
Membrane

PTM

Phosphorylated on Ser-474 by MARK3.

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Anti-KSR2 antibodies

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Mouse Anti-KSR2 Recombinant Antibody (6C9) (CBMAB-K2076-LY)

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Target: KSR2

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: 6C9

Application*: IF, WB

Mouse Anti-KSR2 Recombinant Antibody (4H2) (CBMAB-K2073-LY)

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Target: KSR2

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: 4H2

Application*: E, WB

Mouse Anti-KSR2 Recombinant Antibody (3F11) (CBMAB-K2072-LY)

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Target: KSR2

Host: Mouse

Antibody Isotype: IgG2b, κ

Specificity: Human

Clone: 3F11

Application*: E, WB

Mouse Anti-KSR2 Recombinant Antibody (2G12) (CBMAB-K2071-LY)

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Target: KSR2

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: 2G12

Application*: E, WB

Mouse Anti-KSR2 Recombinant Antibody (1G4) (CBMAB-K2070-LY)

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Target: KSR2

Host: Mouse

Antibody Isotype: IgG2b, κ

Specificity: Human

Clone: 1G4

Application*: WB

Human Recombinant KSR2 protein, GST Tag (V2LY-0526-LY5220)

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Target: KSR2

Expressed Host: Baculovirus-Insect Cells

Sequence: Amino Acid: 554-end

Tag: GST Tag

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Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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