KSR2

Location-regulated scaffold connecting MEK to RAF. Has very low protein kinase activity and can phosphorylate MAP2K1 at several Ser and Thr residues with very low efficiency (in vitro). Interaction with BRAF enhances KSR2-mediated phosphorylation of MAP2K1 (in vitro). Blocks MAP3K8 kinase activity and MAP3K8-mediated signaling. Acts as a negative regulator of MAP3K3-mediated activation of ERK, JNK and NF-kappa-B pathways, inhibiting MAP3K3-mediated interleukin-8 production.
Full Name
kinase suppressor of ras 2
Function
Location-regulated scaffold connecting MEK to RAF. Has very low protein kinase activity and can phosphorylate MAP2K1 at several Ser and Thr residues with very low efficiency (in vitro). Acts as MAP2K1/MEK1-dependent allosteric activator of BRAF; upon binding to MAP2K1/MEK1, dimerizes with BRAF and promotes BRAF-mediated phosphorylation of MAP2K1/MEK1 (PubMed:29433126).
Interaction with BRAF enhances KSR2-mediated phosphorylation of MAP2K1 (in vitro). Blocks MAP3K8 kinase activity and MAP3K8-mediated signaling. Acts as a negative regulator of MAP3K3-mediated activation of ERK, JNK and NF-kappa-B pathways, inhibiting MAP3K3-mediated interleukin-8 production.
Biological Process
Calcium-mediated signalingManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of cold-induced thermogenesisBy SimilarityISS:YuBioLab
Ras protein signal transductionManual Assertion Based On ExperimentIBA:GO_Central
Signal transductionManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Cytoplasm
Membrane
PTM
Phosphorylated on Ser-474 by MARK3.
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Anti-KSR2 antibodies

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Mouse Anti-KSR2 Recombinant Antibody (6C9) (CBMAB-K2076-LY)

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Target: KSR2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 6C9
Application*: IF, WB
Datasheet SDS

Mouse Anti-KSR2 Recombinant Antibody (4H2) (CBMAB-K2073-LY)

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Target: KSR2
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 4H2
Application*: E, WB
Datasheet SDS

Mouse Anti-KSR2 Recombinant Antibody (3F11) (CBMAB-K2072-LY)

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Target: KSR2
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: 3F11
Application*: E, WB
Datasheet SDS

Mouse Anti-KSR2 Recombinant Antibody (2G12) (CBMAB-K2071-LY)

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Target: KSR2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 2G12
Application*: E, WB
Datasheet SDS

Mouse Anti-KSR2 Recombinant Antibody (1G4) (CBMAB-K2070-LY)

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Target: KSR2
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: 1G4
Application*: WB
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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