Human Recombinant KSR2 protein, GST Tag (V2LY-0526-LY5220)

Name: Human Recombinant KSR2 protein, GST Tag
SKU: V2LY-0526-LY5220
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

Baculovirus-Insect Cells

Protein Species

Human

Tag

GST Tag

Protein Construction

This product is Human Recombinant KSR2 protein, GST Tag consist of Amino Acid: 554-end and predicts a molecular mass of 72 kDa.

Molecule Mass

72 kDa

Sequence

Amino Acid: 554-end

Species

Human

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

Batch dependent.

Endotoxin

Please contact us for more information.

Format

Liquid

Buffer

Tris, NaCl, Glutathione, EDTA, DTT, PMSF, Glycerol

Preservative

None

Storage

Store product at -70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

More Infomation

Target

Full Name

kinase suppressor of ras 2

Function

Location-regulated scaffold connecting MEK to RAF. Has very low protein kinase activity and can phosphorylate MAP2K1 at several Ser and Thr residues with very low efficiency (in vitro). Acts as MAP2K1/MEK1-dependent allosteric activator of BRAF; upon binding to MAP2K1/MEK1, dimerizes with BRAF and promotes BRAF-mediated phosphorylation of MAP2K1/MEK1 (PubMed:29433126).
Interaction with BRAF enhances KSR2-mediated phosphorylation of MAP2K1 (in vitro). Blocks MAP3K8 kinase activity and MAP3K8-mediated signaling. Acts as a negative regulator of MAP3K3-mediated activation of ERK, JNK and NF-kappa-B pathways, inhibiting MAP3K3-mediated interleukin-8 production.

Biological Process

Calcium-mediated signalingManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of cold-induced thermogenesisBy SimilarityISS:YuBioLab
Ras protein signal transductionManual Assertion Based On ExperimentIBA:GO_Central
Signal transductionManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

Cytoplasm
Membrane

PTM

Phosphorylated on Ser-474 by MARK3.

Huisman, D. H., Frodyma, D. E., Svoboda, R. A., Vieira, H. M., Chatterjee, D., Skupa, S., ... & Lewis, R. E. (2022). Kinase Suppressor of Ras 2 regulates small-cell lung carcinoma tumor propagating cells. bioRxiv, 2022-02.

Gao, C., Wang, S. W., Lu, J. C., Chai, X. Q., Li, Y. C., Zhang, P. F., ... & Fan, J. (2022). KSR2-14–3-3ζ complex serves as a biomarker and potential therapeutic target in sorafenib-resistant hepatocellular carcinoma. Biomarker Research, 10(1), 25.

Gomez, G. A., Rundle, C. H., Xing, W., Kesavan, C., Pourteymoor, S., Lewis, R. E., ... & Mohan, S. (2022). Contrasting effects of Ksr2, an obesity gene, on trabecular bone volume and bone marrow adiposity. Elife, 11, e82810.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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