LAMP5

LAMP5 (Lysosomal Associated Membrane Protein Family Member 5) plays a role in short-term synaptic plasticity in a subset of GABAergic neurons in the brain.

Full Name

Lysosomal Associated Membrane Protein Family Member 5

Function

Plays a role in short-term synaptic plasticity in a subset of GABAergic neurons in the brain.

Biological Process

Establishment of protein localization to organelleManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

Cell membrane
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane
Endoplasmic reticulum-Golgi intermediate compartment membrane
Endosome membrane
Cytoplasmic vesicle membrane
Cell projection, dendrite
Cell projection, growth cone membrane
Early endosome membrane
Recycling endosome
Recycles from the vesicles of the endocytic recycling compartment (ERC) to the plasma membrane (By similarity).
Colocalizes with UNC93B1 in large endosomal intracellular vesicles (PubMed:21642595).
Accumulates in the endoplasmic reticulum-Golgi intermediate compartment (ERGIC) before its disappearance upon activation by CpG dinucleotides (PubMed:21642595).
Associates with cortical membranes (PubMed:21642595).
Localizes mostly in cytoplasmic vesicles of neuronal cell body (By similarity).
Localizes to synaptic vesicles in a subset of GABAergic neurons (By similarity).By Similarity1 Publication

Topology

Extracellular: 30-235
Helical: 236-256
Cytoplasmic: 257-280

PTM

Glycosylated.