Recombinant Anti-LAMP5 Recombinant Antibody (CBYJL-1175) (CBMAB-L0674-YJ)

Name: Recombinant Anti-LAMP5 Recombinant Antibody (CBYJL-1175)
SKU: CBMAB-L0674-YJ
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Human

Clone

CBYJL-1175

Application

Host Species

Human

Specificity

Human

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer

PBS, pH 7.4

Preservative

0.05% Sodium Azide

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Lysosomal Associated Membrane Protein Family Member 5

Introduction

LAMP5 (Lysosomal Associated Membrane Protein Family Member 5) plays a role in short-term synaptic plasticity in a subset of GABAergic neurons in the brain.

Entrez Gene ID

24141

UniProt ID

Q9UJQ1

Alternative Names

BAD-LAMP; BADLAMP; C20orf103; LAMP-5; UNC-46

Function

Plays a role in short-term synaptic plasticity in a subset of GABAergic neurons in the brain.

Biological Process

Establishment of protein localization to organelleManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

Cell membrane
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane
Endoplasmic reticulum-Golgi intermediate compartment membrane
Endosome membrane
Cytoplasmic vesicle membrane
Cell projection, dendrite
Cell projection, growth cone membrane
Early endosome membrane
Recycling endosome
Recycles from the vesicles of the endocytic recycling compartment (ERC) to the plasma membrane (By similarity).
Colocalizes with UNC93B1 in large endosomal intracellular vesicles (PubMed:21642595).
Accumulates in the endoplasmic reticulum-Golgi intermediate compartment (ERGIC) before its disappearance upon activation by CpG dinucleotides (PubMed:21642595).
Associates with cortical membranes (PubMed:21642595).
Localizes mostly in cytoplasmic vesicles of neuronal cell body (By similarity).
Localizes to synaptic vesicles in a subset of GABAergic neurons (By similarity).By Similarity1 Publication

Topology

Extracellular: 30-235
Helical: 236-256
Cytoplasmic: 257-280

PTM

Glycosylated.

Li, N., Chen, L., Zhao, X., Gu, C., Chang, Y., & Feng, S. (2023). Targeting ANXA7/LAMP5-mTOR axis attenuates spinal cord injury by inhibiting neuronal apoptosis via enhancing autophagy in mice. Cell Death Discovery, 9(1), 309.

Chen, Y., & Ma, T. (2023). LAMP5 may promote MM progression by activating p38. Pathology and Oncology Research, 29, 1611083.

Wang, H., Rueda, L. Y. M., Dang, M., Lee, H. C., Patel, K. K., Thomas, S. K., ... & Orlowski, R. Z. (2023). Lysosomal Associated Membrane Protein Family Member 5 (LAMP5) As a Novel Mediator of, and Target in High Risk Multiple Myeloma (MM). Blood, 142, 873.

Panahi, N., Hylkema, T., Hawkins, G., Manselle, M. K., Peplinski, J. H., Wallace, L. K., ... & Kirkey, D. C. (2023). LAMP5 Is an AML-Restricted Immunotherapeutic Target Enriched in High-Risk Acute Myeloid Leukemia. Blood, 142, 1585.

Deng, Y., Bi, M., Delerue, F., Forrest, S. L., Chan, G., van der Hoven, J., ... & Ittner, L. M. (2022). Loss of LAMP5 interneurons drives neuronal network dysfunction in Alzheimer’s disease. Acta Neuropathologica, 144(4), 637-650.

Gracia-Maldonado, G., Clark, J., Burwinkel, M., Greenslade, B., Wunderlich, M., Salomonis, N., ... & Lee, L. H. (2022). LAMP-5 is an essential inflammatory-signaling regulator and novel immunotherapy target for Mixed Lineage Leukemia-Rearranged acute leukemia. haematologica, 107(4), 803.

Qian, Z., & Zhang, W. (2022). Differentially expressed gene profile and relevant pathways of the inhibition of LAMP5 on MLL-rearranged leukemias. bioRxiv, 2022-08.

Wang, W. T., Chen, T. Q., Zeng, Z. C., Pan, Q., Huang, W., Han, C., ... & Chen, Y. Q. (2020). The lncRNA LAMP5-AS1 drives leukemia cell stemness by directly modulating DOT1L methyltransferase activity in MLL leukemia. Journal of hematology & oncology, 13, 1-19.

Wang, W. T., Han, C., Sun, Y. M., Chen, Z. H., Fang, K., Huang, W., ... & Chen, Y. Q. (2019). Activation of the lysosome-associated membrane protein LAMP5 by DOT1L serves as a bodyguard for MLL fusion oncoproteins to evade degradation in leukemia. Clinical Cancer Research, 25(9), 2795-2808.

Koebis, M., Urata, S., Shinoda, Y., Okabe, S., Yamasoba, T., Nakao, K., ... & Furuichi, T. (2019). LAMP5 in presynaptic inhibitory terminals in the hindbrain and spinal cord: a role in startle response and auditory processing. Molecular Brain, 12(1), 1-13.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Related Products

Mouse Anti-LAMP5 Recombinant Antibody (CBYJL-1174) (CAT#: CBMAB-L0672-YJ)

Rat Anti-LAMP5 Recombinant Antibody (34.2) (CAT#: CBMAB-L0673-YJ)

Isotype control

For research use only. Not intended for any clinical use.

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