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Mouse Anti-LAMP5 Recombinant Antibody (CBYJL-1174) (CBMAB-L0672-YJ)

Provided herein is a Mouse monoclonal antibody, which binds to Lysosomal Associated Membrane Protein Family Member 5 (LAMP5). The antibody can be used for immunoassay techniques, such as ICFC.
See all LAMP5 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYJL-1174
Antibody Isotype
IgG1, κ
Application
ICFC

Basic Information

Immunogen
Cells expressing C20orf103.
Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.2
Preservative
0.09% Sodium Azide
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Lysosomal Associated Membrane Protein Family Member 5
Introduction
LAMP5 (Lysosomal Associated Membrane Protein Family Member 5) plays a role in short-term synaptic plasticity in a subset of GABAergic neurons in the brain.
Entrez Gene ID
24141
UniProt ID
Q9UJQ1
Alternative Names
BAD-LAMP; BADLAMP; C20orf103; LAMP-5; UNC-46
Function
Plays a role in short-term synaptic plasticity in a subset of GABAergic neurons in the brain.
Biological Process
Establishment of protein localization to organelleManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Cell membrane
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane
Endoplasmic reticulum-Golgi intermediate compartment membrane
Endosome membrane
Cytoplasmic vesicle membrane
Cell projection, dendrite
Cell projection, growth cone membrane
Early endosome membrane
Recycling endosome
Recycles from the vesicles of the endocytic recycling compartment (ERC) to the plasma membrane (By similarity).
Colocalizes with UNC93B1 in large endosomal intracellular vesicles (PubMed:21642595).
Accumulates in the endoplasmic reticulum-Golgi intermediate compartment (ERGIC) before its disappearance upon activation by CpG dinucleotides (PubMed:21642595).
Associates with cortical membranes (PubMed:21642595).
Localizes mostly in cytoplasmic vesicles of neuronal cell body (By similarity).
Localizes to synaptic vesicles in a subset of GABAergic neurons (By similarity).By Similarity1 Publication
Topology
Extracellular: 30-235
Helical: 236-256
Cytoplasmic: 257-280
PTM
Glycosylated.

Li, N., Chen, L., Zhao, X., Gu, C., Chang, Y., & Feng, S. (2023). Targeting ANXA7/LAMP5-mTOR axis attenuates spinal cord injury by inhibiting neuronal apoptosis via enhancing autophagy in mice. Cell Death Discovery, 9(1), 309.

Chen, Y., & Ma, T. (2023). LAMP5 may promote MM progression by activating p38. Pathology and Oncology Research, 29, 1611083.

Wang, H., Rueda, L. Y. M., Dang, M., Lee, H. C., Patel, K. K., Thomas, S. K., ... & Orlowski, R. Z. (2023). Lysosomal Associated Membrane Protein Family Member 5 (LAMP5) As a Novel Mediator of, and Target in High Risk Multiple Myeloma (MM). Blood, 142, 873.

Panahi, N., Hylkema, T., Hawkins, G., Manselle, M. K., Peplinski, J. H., Wallace, L. K., ... & Kirkey, D. C. (2023). LAMP5 Is an AML-Restricted Immunotherapeutic Target Enriched in High-Risk Acute Myeloid Leukemia. Blood, 142, 1585.

Deng, Y., Bi, M., Delerue, F., Forrest, S. L., Chan, G., van der Hoven, J., ... & Ittner, L. M. (2022). Loss of LAMP5 interneurons drives neuronal network dysfunction in Alzheimer’s disease. Acta Neuropathologica, 144(4), 637-650.

Gracia-Maldonado, G., Clark, J., Burwinkel, M., Greenslade, B., Wunderlich, M., Salomonis, N., ... & Lee, L. H. (2022). LAMP-5 is an essential inflammatory-signaling regulator and novel immunotherapy target for Mixed Lineage Leukemia-Rearranged acute leukemia. haematologica, 107(4), 803.

Qian, Z., & Zhang, W. (2022). Differentially expressed gene profile and relevant pathways of the inhibition of LAMP5 on MLL-rearranged leukemias. bioRxiv, 2022-08.

Wang, W. T., Chen, T. Q., Zeng, Z. C., Pan, Q., Huang, W., Han, C., ... & Chen, Y. Q. (2020). The lncRNA LAMP5-AS1 drives leukemia cell stemness by directly modulating DOT1L methyltransferase activity in MLL leukemia. Journal of hematology & oncology, 13, 1-19.

Wang, W. T., Han, C., Sun, Y. M., Chen, Z. H., Fang, K., Huang, W., ... & Chen, Y. Q. (2019). Activation of the lysosome-associated membrane protein LAMP5 by DOT1L serves as a bodyguard for MLL fusion oncoproteins to evade degradation in leukemia. Clinical Cancer Research, 25(9), 2795-2808.

Koebis, M., Urata, S., Shinoda, Y., Okabe, S., Yamasoba, T., Nakao, K., ... & Furuichi, T. (2019). LAMP5 in presynaptic inhibitory terminals in the hindbrain and spinal cord: a role in startle response and auditory processing. Molecular Brain, 12(1), 1-13.

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For research use only. Not intended for any clinical use.

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We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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