LBP
Plays a role in the innate immune response. Binds to the lipid A moiety of bacterial lipopolysaccharides (LPS), a glycolipid present in the outer membrane of all Gram-negative bacteria.
Full Name
LBP
Function
Plays a role in the innate immune response. Binds to the lipid A moiety of bacterial lipopolysaccharides (LPS), a glycolipid present in the outer membrane of all Gram-negative bacteria (PubMed:7517398, PubMed:24120359).
Acts as an affinity enhancer for CD14, facilitating its association with LPS. Promotes the release of cytokines in response to bacterial lipopolysaccharide (PubMed:7517398, PubMed:24120359).
Acts as an affinity enhancer for CD14, facilitating its association with LPS. Promotes the release of cytokines in response to bacterial lipopolysaccharide (PubMed:7517398, PubMed:24120359).
Biological Process
Acute-phase responseManual Assertion Based On ExperimentIEP:BHF-UCL
Cellular defense responseBy SimilarityISS:BHF-UCL
Cellular response to lipopolysaccharideManual Assertion Based On ExperimentIDA:MGI
Cellular response to lipoteichoic acidManual Assertion Based On ExperimentIDA:MGI
Defense response to Gram-negative bacteriumManual Assertion Based On ExperimentIDA:BHF-UCL
Defense response to Gram-positive bacteriumManual Assertion Based On ExperimentIDA:BHF-UCL
Detection of molecule of bacterial originManual Assertion Based On ExperimentIDA:BHF-UCL
Innate immune responseBy SimilarityISS:BHF-UCL
Leukocyte chemotaxis involved in inflammatory responseIEA:Ensembl
Lipopolysaccharide transportManual Assertion Based On ExperimentIDA:BHF-UCL
Lipopolysaccharide-mediated signaling pathwayManual Assertion Based On ExperimentIDA:BHF-UCL
Macromolecule localizationManual Assertion Based On ExperimentIDA:AgBase
Macrophage activation involved in immune responseManual Assertion Based On ExperimentIMP:UniProtKB
Negative regulation of tumor necrosis factor productionManual Assertion Based On ExperimentIDA:BHF-UCL
OpsonizationBy SimilarityISS:BHF-UCL
Positive regulation of chemokine productionIEA:Ensembl
Positive regulation of cytolysisManual Assertion Based On ExperimentIDA:AgBase
Positive regulation of interleukin-6 productionManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of interleukin-8 productionManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of macrophage activationManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of neutrophil chemotaxisIEA:Ensembl
Positive regulation of respiratory burst involved in inflammatory responseISS:BHF-UCL
Positive regulation of toll-like receptor 4 signaling pathwayManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of tumor necrosis factor productionManual Assertion Based On ExperimentIDA:BHF-UCL
Response to lipopolysaccharideManual Assertion Based On ExperimentIDA:BHF-UCL
Cellular defense responseBy SimilarityISS:BHF-UCL
Cellular response to lipopolysaccharideManual Assertion Based On ExperimentIDA:MGI
Cellular response to lipoteichoic acidManual Assertion Based On ExperimentIDA:MGI
Defense response to Gram-negative bacteriumManual Assertion Based On ExperimentIDA:BHF-UCL
Defense response to Gram-positive bacteriumManual Assertion Based On ExperimentIDA:BHF-UCL
Detection of molecule of bacterial originManual Assertion Based On ExperimentIDA:BHF-UCL
Innate immune responseBy SimilarityISS:BHF-UCL
Leukocyte chemotaxis involved in inflammatory responseIEA:Ensembl
Lipopolysaccharide transportManual Assertion Based On ExperimentIDA:BHF-UCL
Lipopolysaccharide-mediated signaling pathwayManual Assertion Based On ExperimentIDA:BHF-UCL
Macromolecule localizationManual Assertion Based On ExperimentIDA:AgBase
Macrophage activation involved in immune responseManual Assertion Based On ExperimentIMP:UniProtKB
Negative regulation of tumor necrosis factor productionManual Assertion Based On ExperimentIDA:BHF-UCL
OpsonizationBy SimilarityISS:BHF-UCL
Positive regulation of chemokine productionIEA:Ensembl
Positive regulation of cytolysisManual Assertion Based On ExperimentIDA:AgBase
Positive regulation of interleukin-6 productionManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of interleukin-8 productionManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of macrophage activationManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of neutrophil chemotaxisIEA:Ensembl
Positive regulation of respiratory burst involved in inflammatory responseISS:BHF-UCL
Positive regulation of toll-like receptor 4 signaling pathwayManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of tumor necrosis factor productionManual Assertion Based On ExperimentIDA:BHF-UCL
Response to lipopolysaccharideManual Assertion Based On ExperimentIDA:BHF-UCL
Cellular Location
Secreted
Cytoplasmic granule membrane
Membrane-associated in polymorphonuclear Leukocytes (PMN) granules.
Cytoplasmic granule membrane
Membrane-associated in polymorphonuclear Leukocytes (PMN) granules.
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Anti-LBP antibodies
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CompareTarget: LBP
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: A869
Application*: ELISA, IHC, WB
Target: LBP
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBHb143
Application*: FuncS, Immuno assays, IP
Target: LBP
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Cattle, Dog, Goat, Monkey, Rabbit, Rat, Sheep, Pig
Clone: CBHb142
Application*: FuncS, Immuno assays, IP
Target: LBP
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: CBHb019
Application*: FuncS, Immuno assays
Target: LBP
Sensitivity: 0.12 ng/mL
Detection Range: 0.2-60 ng/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Human
Assay Type: Sandwich
Reactivity: Human
Target: LBP
Sensitivity: 4.99 ng/mL
Detection Range: 10-2000 ng/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Cattle
Assay Type: Sandwich
Reactivity: Cattle
Target: Lbp
Sensitivity: 0.12 μg/mL
Detection Range: 0.3-90 μg/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Mouse
Assay Type: Sandwich
Reactivity: Mouse
Target: Lbp
Sensitivity: 0.12 μg/mL
Detection Range: 0.3-90 μg/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Mouse
Assay Type: Sandwich
Reactivity: Mouse
Target: Lbp
Sensitivity: 0.0093 ng/mL
Detection Range: 0.02-7 ng/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Rat
Assay Type: Sandwich
Reactivity: Rat
Target: LBP
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-481
Tag: His Tag
Target: LBP
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Cattle, Dog, Goat, Monkey, Rabbit, Rat, Sheep, Pig
Clone: CBFYA-0091
Application*: FN, IA, IP
Target: LBP
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: CBFYA-0012
Application*: FN, IA, WB
Target: LBP
Host: Mouse
Antibody Isotype: IgG
Specificity: Rat
Clone: CBYCL-143
Application*: WB, IC, P, C, E
Target: LBP
Host: Mouse
Antibody Isotype: IgG1
Specificity: Mouse, Rat
Clone: 6D528
Application*: E, WB
Target: Lbp
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: 9G212
Application*: WB
Target: Lbp
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: CBYJL-2509
Application*: FN, WB
Target: Lbp
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: RR433-8
Application*: E, F, WB
Target: Lbp
Host: Rat
Antibody Isotype: IgG
Specificity: Mouse
Clone: CBYJL-2507
Application*: E, N
Target: Lbp
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: M330-19
Application*: E, FN, N, WB
Target: Lbp
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: M300-19
Application*: WB
Target: Lbp
Host: Mouse
Antibody Isotype: IgG1
Specificity: Mouse
Clone: CBYJL-2506
Application*: WB, FN, E
Target: Lbp
Host: Rat
Antibody Isotype: IgG1
Specificity: Mouse
Clone: CBYJL-2505
Application*: E
Target: Lbp
Host: Rat
Antibody Isotype: IgG2
Specificity: Mouse
Clone: CBYJL-2504
Application*: WB, N
Target: Lbp
Host: Rat
Antibody Isotype: IgG1
Specificity: Mouse
Clone: CBYJL-2502
Application*: E, N
Target: LBP
Host: Mouse
Antibody Isotype: IgM, κ
Specificity: Human
Clone: CBYJL-1237
Application*: E, WB
Target: LBP
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBYJL-1236
Application*: E, WB, IH
Target: LBP
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Dog, Monkey, Pig, Rat, Goat, Rabbit, Sheep, Cattle
Clone: CBYJL-1235
Application*: IA, IP, FN
Target: LBP
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: biG 42
Application*: WB, FN, E, P
Target: LBP
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: biG 412
Application*: FN, E
Target: LBP
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 9G216
Application*: E, IP
Target: LBP
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Cattle, Dog, Goat, Monkey, Pig, Rabbit, Rat, Sheep
Clone: 9G215
Application*: E, IP
Target: LBP
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Cattle, Dog, Goat, Monkey, Pig, Rabbit, Rat, Sheep
Clone: 6G3
Application*: ED, EC, IP, FN
Target: LBP
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 6D531
Application*: E, IH, WB
Target: LBP
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 6D530
Application*: E
Target: LBP
Host: Mouse
Antibody Isotype: IgM, κ
Specificity: Human
Clone: 4E8
Application*: E, WB
Target: LBP
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBYJL-1233
Application*: E, WB, IH
Target: LBP
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 1C7
Application*: FN, IP
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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