LBP

Plays a role in the innate immune response. Binds to the lipid A moiety of bacterial lipopolysaccharides (LPS), a glycolipid present in the outer membrane of all Gram-negative bacteria.

LBP

Plays a role in the innate immune response. Binds to the lipid A moiety of bacterial lipopolysaccharides (LPS), a glycolipid present in the outer membrane of all Gram-negative bacteria (PubMed:7517398, PubMed:24120359).
Acts as an affinity enhancer for CD14, facilitating its association with LPS. Promotes the release of cytokines in response to bacterial lipopolysaccharide (PubMed:7517398, PubMed:24120359).

Acute-phase responseManual Assertion Based On ExperimentIEP:BHF-UCL
Cellular defense responseBy SimilarityISS:BHF-UCL
Cellular response to lipopolysaccharideManual Assertion Based On ExperimentIDA:MGI
Cellular response to lipoteichoic acidManual Assertion Based On ExperimentIDA:MGI
Defense response to Gram-negative bacteriumManual Assertion Based On ExperimentIDA:BHF-UCL
Defense response to Gram-positive bacteriumManual Assertion Based On ExperimentIDA:BHF-UCL
Detection of molecule of bacterial originManual Assertion Based On ExperimentIDA:BHF-UCL
Innate immune responseBy SimilarityISS:BHF-UCL
Leukocyte chemotaxis involved in inflammatory responseIEA:Ensembl
Lipopolysaccharide transportManual Assertion Based On ExperimentIDA:BHF-UCL
Lipopolysaccharide-mediated signaling pathwayManual Assertion Based On ExperimentIDA:BHF-UCL
Macromolecule localizationManual Assertion Based On ExperimentIDA:AgBase
Macrophage activation involved in immune responseManual Assertion Based On ExperimentIMP:UniProtKB
Negative regulation of tumor necrosis factor productionManual Assertion Based On ExperimentIDA:BHF-UCL
OpsonizationBy SimilarityISS:BHF-UCL
Positive regulation of chemokine productionIEA:Ensembl
Positive regulation of cytolysisManual Assertion Based On ExperimentIDA:AgBase
Positive regulation of interleukin-6 productionManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of interleukin-8 productionManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of macrophage activationManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of neutrophil chemotaxisIEA:Ensembl
Positive regulation of respiratory burst involved in inflammatory responseISS:BHF-UCL
Positive regulation of toll-like receptor 4 signaling pathwayManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of tumor necrosis factor productionManual Assertion Based On ExperimentIDA:BHF-UCL
Response to lipopolysaccharideManual Assertion Based On ExperimentIDA:BHF-UCL

Secreted
Cytoplasmic granule membrane
Membrane-associated in polymorphonuclear Leukocytes (PMN) granules.