Human Recombinant LBP protein, His Tag (V2LY-0526-LY5259)

Name: Human Recombinant LBP protein, His Tag
SKU: V2LY-0526-LY5259
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

HEK293 Cells

Protein Species

Human

Tag

His Tag

Protein Construction

This product is Human Recombinant LBP protein, His Tag consist of Amino Acid: 1-481 and predicts a molecular mass of 52.5 kDa.

Molecule Mass

52.5 kDa

Sequence

Amino Acid: 1-481

Species

Human

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

>95% as determined by SDS-PAGE

Endotoxin

Please contact us for more information.

Format

Lyophilized

Reconstitution

Allow the vial and reconstitution buffer to equilibrate to room temperature. Briefly centrifuge or tap down the vial to ensure that all lyophilized powder is collected at the bottom of the vial. For the reconstitution of this product, we recommend adding PBS or sterile water to achieve a final antibody concentration of 1 mg/mL. Allow the vial to reconstitute for 10-15 minutes at room temperature with gentle agitation. Avoid vigorous shaking that can cause foaming and antibody denaturation. Aliquot into volumes based on your experiment and store liquid protein at -20°C or -80°C for long time.

Buffer

Lyophilized from sterile Tris, NaCl, DTT, Glycerol

Preservative

None

Storage

Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

More Infomation

Target

Full Name

LBP

Function

Plays a role in the innate immune response. Binds to the lipid A moiety of bacterial lipopolysaccharides (LPS), a glycolipid present in the outer membrane of all Gram-negative bacteria (PubMed:7517398, PubMed:24120359).
Acts as an affinity enhancer for CD14, facilitating its association with LPS. Promotes the release of cytokines in response to bacterial lipopolysaccharide (PubMed:7517398, PubMed:24120359).

Biological Process

Acute-phase responseManual Assertion Based On ExperimentIEP:BHF-UCL
Cellular defense responseBy SimilarityISS:BHF-UCL
Cellular response to lipopolysaccharideManual Assertion Based On ExperimentIDA:MGI
Cellular response to lipoteichoic acidManual Assertion Based On ExperimentIDA:MGI
Defense response to Gram-negative bacteriumManual Assertion Based On ExperimentIDA:BHF-UCL
Defense response to Gram-positive bacteriumManual Assertion Based On ExperimentIDA:BHF-UCL
Detection of molecule of bacterial originManual Assertion Based On ExperimentIDA:BHF-UCL
Innate immune responseBy SimilarityISS:BHF-UCL
Leukocyte chemotaxis involved in inflammatory responseIEA:Ensembl
Lipopolysaccharide transportManual Assertion Based On ExperimentIDA:BHF-UCL
Lipopolysaccharide-mediated signaling pathwayManual Assertion Based On ExperimentIDA:BHF-UCL
Macromolecule localizationManual Assertion Based On ExperimentIDA:AgBase
Macrophage activation involved in immune responseManual Assertion Based On ExperimentIMP:UniProtKB
Negative regulation of tumor necrosis factor productionManual Assertion Based On ExperimentIDA:BHF-UCL
OpsonizationBy SimilarityISS:BHF-UCL
Positive regulation of chemokine productionIEA:Ensembl
Positive regulation of cytolysisManual Assertion Based On ExperimentIDA:AgBase
Positive regulation of interleukin-6 productionManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of interleukin-8 productionManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of macrophage activationManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of neutrophil chemotaxisIEA:Ensembl
Positive regulation of respiratory burst involved in inflammatory responseISS:BHF-UCL
Positive regulation of toll-like receptor 4 signaling pathwayManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of tumor necrosis factor productionManual Assertion Based On ExperimentIDA:BHF-UCL
Response to lipopolysaccharideManual Assertion Based On ExperimentIDA:BHF-UCL

Cellular Location

Secreted
Cytoplasmic granule membrane
Membrane-associated in polymorphonuclear Leukocytes (PMN) granules.

Chen, S. J., Chi, Y. C., Ho, C. H., Yang, W. S., & Lin, C. H. (2021). Plasma lipopolysaccharide-binding protein reflects risk and progression of Parkinson’s disease. Journal of Parkinson's disease, 11(3), 1129-1139.

Meng, L., Song, Z., Liu, A., Dahmen, U., Yang, X., & Fang, H. (2021). Effects of lipopolysaccharide-binding protein (LBP) single nucleotide polymorphism (SNP) in infections, inflammatory diseases, metabolic disorders and cancers. Frontiers in Immunology, 12, 681810.

Roberts, L. M., & Buford, T. W. (2021). Lipopolysaccharide binding protein is associated with CVD risk in older adults. Aging clinical and experimental research, 33, 1651-1658.

Tobias, P. S. (2020). Lipopolysaccharide-binding protein. In Endotoxin in Health and Disease (pp. 359-367). CRC Press.

Molinaro, A., Koh, A., Wu, H., Schoeler, M., Faggi, M. I., Carreras, A., ... & Caesar, R. (2020). Hepatic expression of lipopolysaccharide-binding protein (Lbp) is induced by the gut microbiota through Myd88 and impairs glucose tolerance in mice independent of obesity. Molecular Metabolism, 37, 100997.

Yu, Y., & Song, G. (2020). Lipopolysaccharide-binding protein and bactericidal/permeability-increasing protein in lipid metabolism and cardiovascular diseases. Lipid transfer in lipoprotein metabolism and cardiovascular disease, 27-35.

Lim, P. S., Chang, Y. K., & Wu, T. K. (2019). Serum lipopolysaccharide-binding protein is associated with chronic inflammation and metabolic syndrome in hemodialysis patients. Blood purification, 47(1-3), 28-36.

Asada, M., Oishi, E., Sakata, S., Hata, J., Yoshida, D., Honda, T., ... & Ninomiya, T. (2019). Serum lipopolysaccharide‐binding protein levels and the incidence of cardiovascular disease in a general Japanese population: the hisayama study. Journal of the American Heart Association, 8(21), e013628.

Citronberg, J. S., Curtis, K. R., White, E., Newcomb, P. A., Newton, K., Atkinson, C., ... & Hullar, M. A. (2018). Association of gut microbial communities with plasma lipopolysaccharide-binding protein (LBP) in premenopausal women. The ISME journal, 12(7), 1631-1641.

Pretorius, E., Page, M. J., Mbotwe, S., & Kell, D. B. (2018). Lipopolysaccharide-binding protein (LBP) can reverse the amyloid state of fibrin seen or induced in Parkinson's disease. PLoS One, 13(3), e0192121.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

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