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Rat Anti-Lbp Recombinant Antibody (CBYJL-2502) (CBMAB-L2894-YJ)

Provided herein is a Rat monoclonal antibody, which binds to Lipopolysaccharide Binding Protein (Lbp). The antibody can be used for immunoassay techniques, such as ELISA, Neut.
See all Lbp antibodies

Summary

Host Animal
Rat
Specificity
Mouse
Clone
CBYJL-2502
Antibody Isotype
IgG1
Application
ELISA, Neut

Basic Information

Specificity
Mouse
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.4
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
LBP
Introduction
Lipopolysaccharide binding protein plays a role in the innate immune response. It binds to the lipid A moiety of bacterial lipopolysaccharides (LPS), a glycolipid present in the outer membrane of all Gram-negative bacteria. It acts as an affinity enhancer for CD14, facilitating its association with LPS (By similarity). Lipopolysaccharide binding protein also promotes the release of cytokines in response to bacterial lipopolysaccharide.
Entrez Gene ID
16803
UniProt ID
Q61805
Alternative Names
Ly88; Bpifd2; lipopolysaccharide-binding protein
Function
Plays a role in the innate immune response. Binds to the lipid A moiety of bacterial lipopolysaccharides (LPS), a glycolipid present in the outer membrane of all Gram-negative bacteria (PubMed:7517398, PubMed:24120359).
Acts as an affinity enhancer for CD14, facilitating its association with LPS. Promotes the release of cytokines in response to bacterial lipopolysaccharide (PubMed:7517398, PubMed:24120359).
Biological Process
Acute-phase responseManual Assertion Based On ExperimentIEP:BHF-UCL
Cellular defense responseBy SimilarityISS:BHF-UCL
Cellular response to lipopolysaccharideManual Assertion Based On ExperimentIDA:MGI
Cellular response to lipoteichoic acidManual Assertion Based On ExperimentIDA:MGI
Defense response to Gram-negative bacteriumManual Assertion Based On ExperimentIDA:BHF-UCL
Defense response to Gram-positive bacteriumManual Assertion Based On ExperimentIDA:BHF-UCL
Detection of molecule of bacterial originManual Assertion Based On ExperimentIDA:BHF-UCL
Innate immune responseBy SimilarityISS:BHF-UCL
Leukocyte chemotaxis involved in inflammatory responseIEA:Ensembl
Lipopolysaccharide transportManual Assertion Based On ExperimentIDA:BHF-UCL
Lipopolysaccharide-mediated signaling pathwayManual Assertion Based On ExperimentIDA:BHF-UCL
Macromolecule localizationManual Assertion Based On ExperimentIDA:AgBase
Macrophage activation involved in immune responseManual Assertion Based On ExperimentIMP:UniProtKB
Negative regulation of tumor necrosis factor productionManual Assertion Based On ExperimentIDA:BHF-UCL
OpsonizationBy SimilarityISS:BHF-UCL
Positive regulation of chemokine productionIEA:Ensembl
Positive regulation of cytolysisManual Assertion Based On ExperimentIDA:AgBase
Positive regulation of interleukin-6 productionManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of interleukin-8 productionManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of macrophage activationManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of neutrophil chemotaxisIEA:Ensembl
Positive regulation of respiratory burst involved in inflammatory responseISS:BHF-UCL
Positive regulation of toll-like receptor 4 signaling pathwayManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of tumor necrosis factor productionManual Assertion Based On ExperimentIDA:BHF-UCL
Response to lipopolysaccharideManual Assertion Based On ExperimentIDA:BHF-UCL
Cellular Location
Secreted
Cytoplasmic granule membrane
Membrane-associated in polymorphonuclear Leukocytes (PMN) granules.

Chen, S. J., Chi, Y. C., Ho, C. H., Yang, W. S., & Lin, C. H. (2021). Plasma lipopolysaccharide-binding protein reflects risk and progression of Parkinson’s disease. Journal of Parkinson's disease, 11(3), 1129-1139.

Meng, L., Song, Z., Liu, A., Dahmen, U., Yang, X., & Fang, H. (2021). Effects of lipopolysaccharide-binding protein (LBP) single nucleotide polymorphism (SNP) in infections, inflammatory diseases, metabolic disorders and cancers. Frontiers in Immunology, 12, 681810.

Roberts, L. M., & Buford, T. W. (2021). Lipopolysaccharide binding protein is associated with CVD risk in older adults. Aging clinical and experimental research, 33, 1651-1658.

Tobias, P. S. (2020). Lipopolysaccharide-binding protein. In Endotoxin in Health and Disease (pp. 359-367). CRC Press.

Molinaro, A., Koh, A., Wu, H., Schoeler, M., Faggi, M. I., Carreras, A., ... & Caesar, R. (2020). Hepatic expression of lipopolysaccharide-binding protein (Lbp) is induced by the gut microbiota through Myd88 and impairs glucose tolerance in mice independent of obesity. Molecular Metabolism, 37, 100997.

Yu, Y., & Song, G. (2020). Lipopolysaccharide-binding protein and bactericidal/permeability-increasing protein in lipid metabolism and cardiovascular diseases. Lipid transfer in lipoprotein metabolism and cardiovascular disease, 27-35.

Lim, P. S., Chang, Y. K., & Wu, T. K. (2019). Serum lipopolysaccharide-binding protein is associated with chronic inflammation and metabolic syndrome in hemodialysis patients. Blood purification, 47(1-3), 28-36.

Asada, M., Oishi, E., Sakata, S., Hata, J., Yoshida, D., Honda, T., ... & Ninomiya, T. (2019). Serum lipopolysaccharide‐binding protein levels and the incidence of cardiovascular disease in a general Japanese population: the hisayama study. Journal of the American Heart Association, 8(21), e013628.

Citronberg, J. S., Curtis, K. R., White, E., Newcomb, P. A., Newton, K., Atkinson, C., ... & Hullar, M. A. (2018). Association of gut microbial communities with plasma lipopolysaccharide-binding protein (LBP) in premenopausal women. The ISME journal, 12(7), 1631-1641.

Pretorius, E., Page, M. J., Mbotwe, S., & Kell, D. B. (2018). Lipopolysaccharide-binding protein (LBP) can reverse the amyloid state of fibrin seen or induced in Parkinson's disease. PLoS One, 13(3), e0192121.

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For research use only. Not intended for any clinical use.

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