LSM2

LSM2 is a member of the LSm family of RNA-binding proteins. LSm proteins form stable heteromers that bind specifically to the 3'-terminal oligo(U) tract of U6 snRNA and may play a role in pre-mRNA splicing by mediating U4/U6 snRNP formation.

Full Name

LSM2 homolog, U6 small nuclear RNA and mRNA degradation associated

Function

Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex) (PubMed:28781166).
The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA (PubMed:10523320).

Biological Process

mRNA catabolic processManual Assertion Based On ExperimentIDA:MGI
mRNA splicing, via spliceosomeManual Assertion Based On ExperimentIDA:UniProtKB
Spliceosomal tri-snRNP complex assemblyManual Assertion Based On ExperimentIDA:MGI

Cellular Location

Nucleus

Anti-LSM2 antibodies

Rabbit Anti-LSm2 Recombinant Antibody (CBYJL-2076) (CBMAB-L2212-YJ)

Datasheet

SDS

Target: LSM2

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human, Mouse, Rat, Monkey

Clone: CBYJL-2076

Application*: WB

Mouse Anti-LSM2 Recombinant Antibody (CBYJL-2074) (CBMAB-L2209-YJ)

Datasheet

SDS

Target: LSM2

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: CBYJL-2074

Application*: E, WB

Mouse Anti-LSM2 Recombinant Antibody (CBXS-6114) (CBMAB-S2949-CQ)

Datasheet

SDS

Target: LSM2

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: CBXS-6114

Application*: E, WB, P

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)