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Rabbit Anti-LSm2 Recombinant Antibody (CBYJL-2076) (CBMAB-L2212-YJ)

Provided herein is a Rabbit monoclonal antibody, which binds to Lsm2 Homolog U6 Small Nuclear Rna And Mrna Degradation Associated (LSm2). The antibody can be used for immunoassay techniques, such as WB.
See all LSm2 antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Rat, Monkey
Clone
CBYJL-2076
Antibody Isotype
IgG
Application
WB

Basic Information

Specificity
Human, Mouse, Rat, Monkey
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.4
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
LSM2 homolog, U6 small nuclear RNA and mRNA degradation associated
Introduction
LSM2 is a member of the LSm family of RNA-binding proteins. LSm proteins form stable heteromers that bind specifically to the 3'-terminal oligo(U) tract of U6 snRNA and may play a role in pre-mRNA splicing by mediating U4/U6 snRNP formation. Pseudogenes of this gene are located on the short arm of chromosomes 6 and 19.
Entrez Gene ID
Human57819
Mouse27756
Rat684148
Monkey715592
UniProt ID
HumanQ9Y333
MouseO35900
RatQ6MG66
MonkeyG7MRK5
Alternative Names
G7B; snRNP; C6orf28; YBL026W; U6 snRNA-associated Sm-like protein LSm2; LSM2 U6 small nuclear RNA and mRNA degradation associated; LSM2 homolog, U6 small nuclear RNA associated; protein G7b; small nuclear ribonuclear protein D homolog; snRNP core Sm-like protein Sm-x5
Function
Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex) (PubMed:28781166).
The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA (PubMed:10523320).
Biological Process
mRNA catabolic processManual Assertion Based On ExperimentIDA:MGI
mRNA splicing, via spliceosomeManual Assertion Based On ExperimentIDA:UniProtKB
Spliceosomal tri-snRNP complex assemblyManual Assertion Based On ExperimentIDA:MGI
Cellular Location
Nucleus
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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