Mouse Anti-LSM2 Recombinant Antibody (CBXS-6114) (CBMAB-S2949-CQ)

This product is a mouse antibody that recognizes LSM2. The antibody CBXS-6114 can be used for immunoassay techniques such as: ELISA, WB, IHC-P.
See all LSM2 antibodies

Datasheet

Summary

Host Animal

Mouse

Specificity

Human

Clone

CBXS-6114

Antibody Isotype

IgG2a, κ

Application

ELISA, WB, IHC-P

Basic Information

Immunogen

Recombinant human LSm2 (1-95aa) purified from E. coli

Specificity

Human

Antibody Isotype

IgG2a, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, pH 7.4

Preservative

0.1% sodium azide

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name

LSM2 homolog, U6 small nuclear RNA and mRNA degradation associated

Entrez Gene ID

57819

UniProt ID

Q9Y333

Alternative Names

C6orf28; G7B; YBL026W; snRNP

Function

Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex) (PubMed:28781166).
The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA (PubMed:10523320).

Biological Process

mRNA catabolic processManual Assertion Based On ExperimentIDA:MGI
mRNA splicing, via spliceosomeManual Assertion Based On ExperimentIDA:UniProtKB
Spliceosomal tri-snRNP complex assemblyManual Assertion Based On ExperimentIDA:MGI

Cellular Location

Nucleus

References

Qin, P., Huang, H., Wang, J., Jiang, T., Zeng, N., Wang, Q., ... & Zhou, Y. (2023). The mechanism of LSM2 in the progression of live hepatocellular carcinoma was analyzed based on bioinformatics. Medical Oncology, 40(9), 276.

Sun, X., Zhang, J., Hu, J., Han, Q., & Ge, Z. (2023). LSM2 is associated with a poor prognosis and promotes cell proliferation, migration, and invasion in skin cutaneous melanoma. BMC Medical Genomics, 16(1), 1-14.

Montemayor, E. J., Virta, J. M., Hayes, S. M., Nomura, Y., Brow, D. A., & Butcher, S. E. (2020). Molecular basis for the distinct cellular functions of the Lsm1–7 and Lsm2–8 complexes. Rna, 26(10), 1400-1413.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Associated Products

Related Products

Mouse Anti-LSM2 Recombinant Antibody (CBYJL-2074)

Rabbit Anti-LSm2 Recombinant Antibody (CBYJL-2076)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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