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MAGEA1

This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditary disorders, such as dyskeratosis congenita. [provided by RefSeq, Jul 2008]
Full Name
MAGE Family Member A1
Function
May be involved in transcriptional regulation through interaction with SNW1 and recruiting histone deactelyase HDAC1. May inhibit notch intracellular domain (NICD) transactivation. May play a role in embryonal development and tumor transformation or aspects of tumor progression. Antigen recognized on a melanoma by autologous cytolytic T-lymphocytes.
Biological Process
Negative regulation of Notch signaling pathwayManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIDA:UniProtKB
Cellular Location
Cytoplasm
Nucleus
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Anti-MAGEA1 antibodies

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Mouse Anti-MAGEA1 Recombinant Antibody (A976) (CBMAB-AP4368LY)

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Target: MAGEA1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Dog, Human
Clone: A976
Application*: FC, IF, IHC
Datasheet SDS

Mouse Anti-MAGEA1 Recombinant Antibody (A975) (CBMAB-AP4370LY)

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Target: MAGEA1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: A975
Application*: FC, IF, IHC
Datasheet SDS

Mouse Anti-MAGEA1 Recombinant Antibody (A974) (CBMAB-AP4366LY)

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Target: MAGEA1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Dog, Human
Clone: A974
Application*: FC, IF, IHC
Datasheet SDS

Mouse Anti-MAGEA1 Recombinant Antibody (3H5) (CBMAB-A5154-LY)

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Target: MAGEA1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 3H5
Application*: WB, E
Datasheet SDS

Recombinant Mouse Anti-MAGEA1 Recombinant Antibody (MA454) (CBMAB-XB0773-YC)

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Target: MAGEA1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: MA454
Application*: IH, WB
Datasheet SDS

Recombinant Mouse Anti-MAGEA1 Recombinant Antibody (6C-1) (CBMAB-XB0772-YC)

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Target: MAGEA1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 6C-1
Application*: WB
Datasheet SDS

Rabbit Anti-MAGEA1 Recombinant Antibody (CBFYM-1301) (CBMAB-M1460-FY)

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Target: MAGEA1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse, Rat, Human
Clone: CBFYM-1301
Application*: WB, IC, F
Datasheet SDS

Mouse Anti-MAGEA1 Recombinant Antibody (CBFYM-1299) (CBMAB-M1458-FY)

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Target: MAGEA1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBFYM-1299
Application*: P, IF, F
Datasheet SDS

Mouse Anti-MAGEA1 Recombinant Antibody (CBFYM-1298) (CBMAB-M1457-FY)

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Target: MAGEA1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBFYM-1298
Application*: E, IF, IH, IP, WB
Datasheet SDS

Mouse Anti-MAGEA1 (AA 98-171) Recombinant Antibody (CBFYM-1297) (CBMAB-M1456-FY)

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Target: MAGEA1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBFYM-1297
Application*: E, WB
Datasheet SDS

Rabbit Anti-MAGEA1 Recombinant Antibody (CBFYM-1295) (CBMAB-M1454-FY)

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Target: MAGEA1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBFYM-1295
Application*: WB, P, F
Datasheet SDS

Mouse Anti-MAGEA1 Recombinant Antibody (CBFYM-0621) (CBMAB-M0755-FY)

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Target: MAGEA1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYM-0621
Application*: IH
Datasheet SDS

Mouse Anti-MAGEA1 Recombinant Antibody (CBFYM-0536) (CBMAB-M0665-FY)

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Target: MAGEA1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBFYM-0536
Application*: E, IC, IF, C, IP, WB
Datasheet SDS

Mouse Anti-MAGEA1 Recombinant Antibody (CBFYM-0423) (CBMAB-M0537-FY)

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Target: MAGEA1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Dog, Human, Rat
Clone: CBFYM-0423
Application*: C, F, IF, IP, P, WB
Datasheet SDS

Mouse Anti-MAGEA1 Recombinant Antibody (CBFYM-0350) (CBMAB-M0427-FY)

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Target: MAGEA1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBFYM-0350
Application*: IF, P, WB
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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