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Recombinant Mouse Anti-MAGEA1 Recombinant Antibody (MA454) (CBMAB-XB0773-YC)

Provided herein is a Mouse Recombinant Antibody against MAGE Family Member A1 . The antibody can be used for immunoassay techniques, such as IHC, WB.
See all MAGEA1 antibodies
Published Data
Fig.1 Immunohistochemistry with six different monoclonal antibodies (mAbs); mAbs MA454, 57B, ES121, and M3H67 were negative.
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Fig.2 Immunohistochemical staining with MA454, normal testis (A, B) and lung carcinomas (C–D).
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Fig.3 Comparison of GAGE, MAGE-1 and NY-ESO-1 staining in normal testis, and analysis of GAGE protein expression in ovary and different types of cancer.
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Summary

Host Animal
Mouse
Specificity
Human
Clone
MA454
Antibody Isotype
IgG1
Application
IHC, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
MAGE Family Member A1
Introduction
MAGE1 is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls.
Entrez Gene ID
4100
UniProt ID
P43355
Alternative Names
Melanoma Antigen Family A, 1 (Directs Expression Of Antigen MZ2-E)
Function
May be involved in transcriptional regulation through interaction with SNW1 and recruiting histone deactelyase HDAC1. May inhibit notch intracellular domain (NICD) transactivation. May play a role in embryonal development and tumor transformation or aspects of tumor progression. Antigen recognized on a melanoma by autologous cytolytic T-lymphocytes.
Biological Process
Negative regulation of Notch signaling pathwayManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIDA:UniProtKB
Cellular Location
Cytoplasm
Nucleus

Mastutik, G., Rahniayu, A., Marhana, I. A., Kurniasari, N., Rahaju, A. S., Amin, M., & Trianto, H. F. (2023). The MAGE A1-A10 Expression associated with Histopathological Findings of Malignant or Non-Malignant Cells in Peripheral Lung Tumors. Asian Pacific Journal of Cancer Prevention: APJCP, 24(7), 2329.

Bassan, D., Gozlan, Y. M., Sharbi‐Yunger, A., Tzehoval, E., Greenstein, E., Bitan, L., ... & Eisenbach, L. (2021). Avidity optimization of a MAGE‐A1‐specific TCR with somatic hypermutation. European journal of immunology, 51(6), 1505-1518.

Jeong, Y. J., Park, S. H., & Jeon, C. H. (2020). Detection of circulating tumor cells in patients with breast cancer using the conditionally reprogrammed cell culture method and reverse transcription‑PCR of hTERT and MAGE A1‑6. Oncology Letters, 20(4), 1-1.

Liu, S., Zhao, Y., Xu, Y., Sang, M., Zhao, R., Gu, L., & Shan, B. (2020). The clinical significance of methylation of MAGE-A1 and-A3 promoters and expression of DNA methyltransferase in patients with laryngeal squamous cell carcinoma. American Journal of Otolaryngology, 41(1), 102318.

Mi, Y., Liu, F., Liang, X., Liu, S., Huang, X., Sang, M., & Geng, C. (2019). Tumor suppressor let-7a inhibits breast cancer cell proliferation, migration and invasion by targeting MAGE-A1. Neoplasma, 66(1), 54-62.

Mao, Y., Fan, W., Hu, H., Zhang, L., Michel, J., Wu, Y., ... & Tang, Q. (2019). MAGE-A1 in lung adenocarcinoma as a promising target of chimeric antigen receptor T cells. Journal of hematology & oncology, 12, 1-18.

Srdelic, S., Kuzmic-Prusac, I., Spagnoli, G. C., Juretic, A., & Capkun, V. (2019). MAGE-A4 and MAGE-A1 immunohistochemical expression in high-grade endometrial cancer. International Journal of Gynecological Pathology, 38(1), 59-65.

Zhao, J., Wang, Y., Liang, Q., Xu, Y., & Sang, J. (2019). MAGEA1 inhibits the expression of BORIS via increased promoter methylation. Journal of Cell Science, 132(1), jcs218628.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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