MAPRE2

The protein encoded by this gene shares significant homology to the adenomatous polyposis coli (APC) protein-binding EB1 gene family. This protein is a microtubule-associated protein that is necessary for spindle symmetry during mitosis. It is thought to play a role in the tumorigenesis of colorectal cancers and the proliferative control of normal cells. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2012]
Full Name
Microtubule Associated Protein RP/EB Family Member 2
Function
May be involved in microtubule polymerization, and spindle function by stabilizing microtubules and anchoring them at centrosomes. May play a role in cell migration (By similarity).
Biological Process
Cell divisionIEA:UniProtKB-KW
Positive regulation of ARF protein signal transductionBy SimilarityISS:ARUK-UCL
Positive regulation of focal adhesion disassemblyBy SimilarityISS:ARUK-UCL
Positive regulation of GTPase activityBy SimilarityISS:ARUK-UCL
Positive regulation of keratinocyte migrationBy SimilarityISS:ARUK-UCL
Protein localization to microtubule plus-endManual Assertion Based On ExperimentIBA:GO_Central
Regulation of microtubule polymerization or depolymerizationManual Assertion Based On ExperimentIBA:GO_Central
Spindle assemblyManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Cytoplasm, cytoskeleton
Associated with the microtubule network. Accumulates at the plus end of microtubules.
Involvement in disease
Skin creases, congenital symmetric circumferential, 2 (CSCSC2):
An autosomal dominant disease characterized by multiple, symmetric, circumferential rings of folded skin, affecting primarily the limbs. Affected individuals also exhibit intellectual disability, cleft palate, and dysmorphic features.
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Anti-MAPRE2 antibodies

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Rat Anti-MAPRE2 Recombinant Antibody (KT52) (CBMAB-AO374LY)

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Target: MAPRE2
Host: Rat
Antibody Isotype: IgG2b
Specificity: Human, Mouse, Monkey
Clone: KT52
Application*: WB, IF
Datasheet SDS

Mouse Anti-MAPRE2 Recombinant Antibody (4D7) (CBMAB-A5291-LY)

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Target: MAPRE2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 4D7
Application*: WB, E
Datasheet SDS

Mouse Anti-MAPRE2 Recombinant Antibody (CBFYM-1675) (CBMAB-M1842-FY)

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Target: MAPRE2
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: CBFYM-1675
Application*: IC, IH, IP, WB
Datasheet SDS

Mouse Anti-MAPRE2 Recombinant Antibody (CBFYM-1674) (CBMAB-M1841-FY)

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Target: MAPRE2
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human, Dog, Rat, Monkey
Clone: CBFYM-1674
Application*: WB, IF, F
Datasheet SDS

Mouse Anti-MAPRE2 (AA 1-63) Recombinant Antibody (CBFYM-1673) (CBMAB-M1840-FY)

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Target: MAPRE2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBFYM-1673
Application*: E, IF, WB
Datasheet SDS

Mouse Anti-MAPRE2 Recombinant Antibody (CBFYM-1672) (CBMAB-M1839-FY)

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Target: MAPRE2
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBFYM-1672
Application*: F, IF, IH, WB
Datasheet SDS

Rat Anti-MAPRE2 Recombinant Antibody (CBFYM-1671) (CBMAB-M1838-FY)

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Target: MAPRE2
Host: Rat
Antibody Isotype: IgG2b
Specificity: Hamster, Human, Mouse
Clone: CBFYM-1671
Application*: E, IF, IP, WB
Datasheet SDS

Mouse Anti-MAPRE2 (AA 1-63) Recombinant Antibody (CBFYM-0491) (CBMAB-M0619-FY)

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Target: MAPRE2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYM-0491
Application*: E, IC, IH, WB
Datasheet SDS

Mouse Anti-MAPRE2 Recombinant Antibody (CBFYE-1547) (CBMAB-E2190-FY)

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Target: MAPRE2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYE-1547
Application*: WB, P
Datasheet SDS

Mouse Anti-MAPRE2 Recombinant Antibody (CBFYE-1546) (CBMAB-E2189-FY)

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Target: MAPRE2
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Rat, Human, Monkey
Clone: CBFYE-1546
Application*: WB, F, CT, IF
Datasheet SDS
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Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized) Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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