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Mouse Anti-MAPRE2 Recombinant Antibody (4D7) (CBMAB-A5291-LY)

The product is antibody recognizes MAPRE2. The antibody 4D7 immunoassay techniques such as: WB, ELISA.
See all MAPRE2 antibodies
Published Data
Fig.1 Subcellular localization of EB3 and EB2 were analyzed by immunostaining of WT hippocampal primary cultures with anti-EB2/3 antibody (green).
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Fig.2 Western blot analysis of STIM2, EB2, EB3 proteins expression levels.
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Summary

Host Animal
Mouse
Specificity
Human
Clone
4D7
Antibody Isotype
IgG1, κ
Application
WB, ELISA

Basic Information

Immunogen
MAPRE2 (NP_055083, 1 a.a. ~ 62 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Microtubule Associated Protein RP/EB Family Member 2
Introduction
The protein encoded by this gene shares significant homology to the adenomatous polyposis coli (APC) protein-binding EB1 gene family. The function of this protein is unknown; however, its homology suggests involvement in tumorigenesis of colorectal cancers and proliferative control of normal cells. This gene may belong to the intermediate/early gene family, involved in the signal transduction cascade downstream of the TCR. Alternative splicing results in multiple transcript variants. [provided by RefSeq]
Entrez Gene ID
10982
UniProt ID
Q15555
Alternative Names
EB1; EB2; RP1
Function
May be involved in microtubule polymerization, and spindle function by stabilizing microtubules and anchoring them at centrosomes. May play a role in cell migration (By similarity).
Biological Process
Cell divisionIEA:UniProtKB-KW
Positive regulation of ARF protein signal transductionBy SimilarityISS:ARUK-UCL
Positive regulation of focal adhesion disassemblyBy SimilarityISS:ARUK-UCL
Positive regulation of GTPase activityBy SimilarityISS:ARUK-UCL
Positive regulation of keratinocyte migrationBy SimilarityISS:ARUK-UCL
Protein localization to microtubule plus-endManual Assertion Based On ExperimentIBA:GO_Central
Regulation of microtubule polymerization or depolymerizationManual Assertion Based On ExperimentIBA:GO_Central
Spindle assemblyManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Cytoplasm, cytoskeleton
Associated with the microtubule network. Accumulates at the plus end of microtubules.
Involvement in disease
Skin creases, congenital symmetric circumferential, 2 (CSCSC2):
An autosomal dominant disease characterized by multiple, symmetric, circumferential rings of folded skin, affecting primarily the limbs. Affected individuals also exhibit intellectual disability, cleft palate, and dysmorphic features.

Chiang, D. Y., Verkerk, A. O., Victorio, R., Shneyer, B. I., van der Vaart, B., Jouni, M., ... & MacRae, C. A. (2023). The Role of MAPRE2 and Microtubules in Maintaining Normal Ventricular Conduction. Circulation Research.

Zhang, D., Pan, G., Cheng, N., Sun, L., Zhou, X., Li, C., & Zhao, J. (2023). JUND facilitates proliferation and angiogenesis of esophageal squamous cell carcinoma cell via MAPRE2 up-regulation. Tissue and Cell, 81, 102010.

Li, Y. Y., Lei, W. L., Zhang, C. F., Sun, S. M., Zhao, B. W., Xu, K., ... & Han, Z. (2022). MAPRE2 regulates the first meiotic progression in mouse oocytes. Experimental Cell Research, 416(1), 113135.

Zhang, D., Li, C., Cheng, N., Sun, L., Zhou, X., Pan, G., & Zhao, J. (2021). CircAGFG1 acts as a sponge of miR-4306 to stimulate esophageal cancer progression by modulating MAPRE2 expression. Acta Histochemica, 123(7), 151776.

Thues, C., Valadas, J. S., Deaulmerie, L., Geens, A., Chouhan, A. K., Duran-Romaña, R., ... & Van Esch, H. (2021). MAPRE2 mutations result in altered human cranial neural crest migration, underlying craniofacial malformations in CSC-KT syndrome. Scientific Reports, 11(1), 4976.

Feng, J., Lan, X., Shen, J., Song, X., Tang, X., Xu, W., ... & Wu, S. (2020). A de novo MAPRE2 variant in a patient with congenital symmetric circumferential skin creases type 2. Molecular Genetics & Genomic Medicine, 8(2), e1096.

Gong, L., Xiao, M., He, D., Hu, Y., Zhu, Y., Xiang, L., ... & Cao, K. (2020). WDHD1 leads to cisplatin resistance by promoting MAPRE2 ubiquitination in lung adenocarcinoma. Frontiers in oncology, 10, 461.

Winkler, S. K. (2020). The role of MAPRE2 as a potential key gene in leukemic stem cells (Doctoral dissertation, Universität Ulm).

Berkun, L., Slae, M., Mor‐Shaked, H., Koplewitz, B., Eventov‐Friedman, S., & Harel, T. (2019). Homozygous variants in MAPRE2 and CDON in individual with skin folds, growth delay, retinal coloboma, and pyloric stenosis. American Journal of Medical Genetics Part A, 179(12), 2454-2458.

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For research use only. Not intended for any clinical use.

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We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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