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Rat Anti-MAPRE2 Recombinant Antibody (KT52) (CBMAB-AO374LY)

The product is antibody recognizes MAPRE2. The antibody KT52 immunoassay techniques such as: WB, IF.
See all MAPRE2 antibodies

Summary

Host Animal
Rat
Specificity
Human, Mouse, Monkey
Clone
KT52
Antibody Isotype
IgG2b
Application
WB, IF

Basic Information

Immunogen
Purified full-length human EB2-GST fusion protein
Specificity
Human, Mouse, Monkey
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Preservative
0.09% sodium azide
Concentration
1 mg/ml
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Microtubule Associated Protein RP/EB Family Member 2
Introduction
The protein encoded by this gene shares significant homology to the adenomatous polyposis coli (APC) protein-binding EB1 gene family. This protein is a microtubule-associated protein that is necessary for spindle symmetry during mitosis. It is thought to play a role in the tumorigenesis of colorectal cancers and the proliferative control of normal cells. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2012]
Entrez Gene ID
Human10982
Mouse212307
Monkey707996
UniProt ID
HumanQ15555
MouseQ8R001
MonkeyF6UH42
Alternative Names
Microtubule-associated protein RP/EB family member 2; End-binding protein 2; EB2; APC-binding protein EB2; RP1; MAPRE2
Function
May be involved in microtubule polymerization, and spindle function by stabilizing microtubules and anchoring them at centrosomes. May play a role in cell migration (By similarity).
Biological Process
Cell divisionIEA:UniProtKB-KW
Positive regulation of ARF protein signal transductionBy SimilarityISS:ARUK-UCL
Positive regulation of focal adhesion disassemblyBy SimilarityISS:ARUK-UCL
Positive regulation of GTPase activityBy SimilarityISS:ARUK-UCL
Positive regulation of keratinocyte migrationBy SimilarityISS:ARUK-UCL
Protein localization to microtubule plus-endManual Assertion Based On ExperimentIBA:GO_Central
Regulation of microtubule polymerization or depolymerizationManual Assertion Based On ExperimentIBA:GO_Central
Spindle assemblyManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Cytoplasm, cytoskeleton
Associated with the microtubule network. Accumulates at the plus end of microtubules.
Involvement in disease
Skin creases, congenital symmetric circumferential, 2 (CSCSC2):
An autosomal dominant disease characterized by multiple, symmetric, circumferential rings of folded skin, affecting primarily the limbs. Affected individuals also exhibit intellectual disability, cleft palate, and dysmorphic features.

Chiang, D. Y., Verkerk, A. O., Victorio, R., Shneyer, B. I., van der Vaart, B., Jouni, M., ... & MacRae, C. A. (2023). The Role of MAPRE2 and Microtubules in Maintaining Normal Ventricular Conduction. Circulation Research.

Zhang, D., Pan, G., Cheng, N., Sun, L., Zhou, X., Li, C., & Zhao, J. (2023). JUND facilitates proliferation and angiogenesis of esophageal squamous cell carcinoma cell via MAPRE2 up-regulation. Tissue and Cell, 81, 102010.

Li, Y. Y., Lei, W. L., Zhang, C. F., Sun, S. M., Zhao, B. W., Xu, K., ... & Han, Z. (2022). MAPRE2 regulates the first meiotic progression in mouse oocytes. Experimental Cell Research, 416(1), 113135.

Zhang, D., Li, C., Cheng, N., Sun, L., Zhou, X., Pan, G., & Zhao, J. (2021). CircAGFG1 acts as a sponge of miR-4306 to stimulate esophageal cancer progression by modulating MAPRE2 expression. Acta Histochemica, 123(7), 151776.

Thues, C., Valadas, J. S., Deaulmerie, L., Geens, A., Chouhan, A. K., Duran-Romaña, R., ... & Van Esch, H. (2021). MAPRE2 mutations result in altered human cranial neural crest migration, underlying craniofacial malformations in CSC-KT syndrome. Scientific Reports, 11(1), 4976.

Feng, J., Lan, X., Shen, J., Song, X., Tang, X., Xu, W., ... & Wu, S. (2020). A de novo MAPRE2 variant in a patient with congenital symmetric circumferential skin creases type 2. Molecular Genetics & Genomic Medicine, 8(2), e1096.

Gong, L., Xiao, M., He, D., Hu, Y., Zhu, Y., Xiang, L., ... & Cao, K. (2020). WDHD1 leads to cisplatin resistance by promoting MAPRE2 ubiquitination in lung adenocarcinoma. Frontiers in oncology, 10, 461.

Winkler, S. K. (2020). The role of MAPRE2 as a potential key gene in leukemic stem cells (Doctoral dissertation, Universität Ulm).

Berkun, L., Slae, M., Mor‐Shaked, H., Koplewitz, B., Eventov‐Friedman, S., & Harel, T. (2019). Homozygous variants in MAPRE2 and CDON in individual with skin folds, growth delay, retinal coloboma, and pyloric stenosis. American Journal of Medical Genetics Part A, 179(12), 2454-2458.

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For research use only. Not intended for any clinical use.

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We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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