MBD3

DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. This gene belongs to a family of nuclear proteins which are characterized by the presence of a methyl-CpG binding domain (MBD). The encoded protein is a subunit of the NuRD, a multisubunit complex containing nucleosome remodeling and histone deacetylase activities. Unlike the other family members, the encoded protein is not capable of binding to methylated DNA. The protein mediates the association of metastasis-associated protein 2 with the core histone deacetylase complex. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jul 2013]

Full Name

Methyl-CpG Binding Domain Protein 3

Function

Acts as transcriptional repressor and plays a role in gene silencing. Does not bind to DNA by itself (PubMed:12124384).

Binds to DNA with a preference for sites containing methylated CpG dinucleotides (in vitro). Binds to a lesser degree DNA containing unmethylated CpG dinucleotides (PubMed:24307175).

Recruits histone deacetylases and DNA methyltransferases.

Biological Process

Aging Source: Ensembl
Brain development Source: Ensembl
Chromatin remodeling Source: ComplexPortal
DNA methylation-dependent heterochromatin assembly Source: Ensembl
Embryonic organ development Source: Ensembl
Heart development Source: Ensembl
Histone acetylation Source: Ensembl
Histone deacetylation Source: ComplexPortal
In utero embryonic development Source: Ensembl
Negative regulation of transcription, DNA-templated Source: ComplexPortal
Negative regulation of transcription by RNA polymerase II Source: Ensembl
Positive regulation of transcription, DNA-templated Source: ComplexPortal
Regulation of cell fate specification Source: ComplexPortal
Regulation of DNA methylation Source: Ensembl
Regulation of stem cell differentiation Source: ComplexPortal
Response to estradiol Source: Ensembl
Response to nutrient levels Source: Ensembl
Tissue development Source: Ensembl

Cellular Location

Nucleus
Other locations
Chromosome
Note: Nuclear, in discrete foci. Detected on chromatin, at promoter regions of active genes.