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MDH2

Malate dehydrogenase catalyzes the reversible oxidation of malate to oxaloacetate, utilizing the NAD/NADH cofactor system in the citric acid cycle. The protein encoded by this gene is localized to the mitochondria and may play pivotal roles in the malate-aspartate shuttle that operates in the metabolic coordination between cytosol and mitochondria. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2013]
Full Name
MDH2
Biological Process
Aerobic respiration Source: UniProtKB
Malate metabolic process Source: UniProtKB
NADH metabolic process Source: Ensembl
Oxaloacetate metabolic process Source: Ensembl
Tricarboxylic acid cycle Source: GO_Central
Cellular Location
Mitochondrion matrix
Involvement in disease
Developmental and epileptic encephalopathy 51 (DEE51):
A form of epileptic encephalopathy, a heterogeneous group of severe early-onset epilepsies characterized by refractory seizures, neurodevelopmental impairment, and poor prognosis. Development is normal prior to seizure onset, after which cognitive and motor delays become apparent. DEE51 is an autosomal recessive form characterized by onset of intractable seizures and hypotonia in the first days or weeks of life, and severely delayed psychomotor development.
PTM
Acetylation is enhanced by up to 67% after treatment either with trichostin A (TSA) or with nicotinamide (NAM) with the appearance of tri- and tetraacetylations. Glucose also increases acetylation by about 60%.
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Anti-MDH2 antibodies

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Rabbit Anti-MDH2 Recombinant Antibody (D8Q5S) (CBMAB-CP1481-LY)

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Target: MDH2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat, Monkey
Clone: D8Q5S
Application*: WB
Datasheet SDS

Mouse Anti-MDH2 Recombinant Antibody (2D9) (CBMAB-A5361-LY)

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Target: MDH2
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 2D9
Application*: SE, E
Datasheet SDS

Mouse Anti-MDH2 Recombinant Antibody (2A7) (CBMAB-A5359-LY)

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Target: MDH2
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: 2A7
Application*: SE, E
Datasheet SDS

Rabbit Anti-MDH2 Recombinant Antibody (CBFYM-1950) (CBMAB-M2125-FY)

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Target: MDH2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse, Rat, Human
Clone: CBFYM-1950
Application*: WB, P, F
Datasheet SDS

Rabbit Anti-MDH2 Recombinant Antibody (CBFYM-1949) (CBMAB-M2124-FY)

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Target: MDH2
Host: Rabbit
Specificity: Human, Mouse, Rat, Monkey
Clone: CBFYM-1949
Application*: WB
Datasheet SDS

Mouse Anti-MDH2 Recombinant Antibody (CBFYM-1948) (CBMAB-M2123-FY)

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Target: MDH2
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBFYM-1948
Application*: E, P, WB
Datasheet SDS

Mouse Anti-MDH2 Recombinant Antibody (CBFYM-1946) (CBMAB-M2121-FY)

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Target: MDH2
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBFYM-1946
Application*: WB, E
Datasheet SDS

Mouse Anti-MDH2 (AA 134-247) Recombinant Antibody (CBFYM-1945) (CBMAB-M2120-FY)

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Target: MDH2
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: CBFYM-1945
Application*: E
Datasheet SDS

Mouse Anti-MDH2 (AA 134-246) Recombinant Antibody (CBFYM-1944) (CBMAB-M2119-FY)

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Target: MDH2
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBFYM-1944
Application*: E
Datasheet SDS

Mouse Anti-MDH2 Recombinant Antibody (2F5AF8) (CBMAB-M2118-FY)

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Target: MDH2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 2F5AF8
Application*: E, IC, IP
Datasheet SDS

Mouse Anti-MDH2 Recombinant Antibody (14H3) (CBMAB-0744-CN)

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Target: MDH2
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: 14H3
Application*: E, M
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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