MMP10
This gene encodes a member of the peptidase M10 family of matrix metalloproteinases (MMPs). Proteins in this family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. The encoded preproprotein is proteolytically processed to generate the mature protease. This secreted protease breaks down fibronectin, laminin, elastin, proteoglycan core protein, gelatins, and several types of collagen. The gene is part of a cluster of MMP genes on chromosome 11.
Full Name
matrix metallopeptidase 10
Function
Can degrade fibronectin, gelatins of type I, III, IV, and V; weakly collagens III, IV, and V. Activates procollagenase.
Biological Process
Collagen catabolic process Source: GO_Central
Extracellular matrix disassembly Source: Reactome
Extracellular matrix organization Source: GO_Central
Proteolysis Source: ProtInc
Extracellular matrix disassembly Source: Reactome
Extracellular matrix organization Source: GO_Central
Proteolysis Source: ProtInc
Cellular Location
Extracellular matrix
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Anti-MMP10 antibodies
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Target: MMP10
Host: Mouse
Specificity: Rat
Clone: CBXS-0044
Application*: WB, IC, P, C, E
Target: MMP10
Host: Mouse
Specificity: Human
Clone: CBXS-0043
Application*: WB, IC, P, C, E
Target: MMP10
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Rat
Clone: CBFYM-2347
Application*: WB
Target: MMP10
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBFYM-2346
Application*: IH, IP, WB
Target: MMP10
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYM-2345
Application*: WB, IH
Target: MMP10
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBFYM-0664
Application*: IP, WB
Target: MMP10
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYM-0168
Application*: E
Target: MMP10
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYM-0026
Application*: F
Target: MMP10
Sensitivity: 0.28 ng/mL
Detection Range: 0.5-150 ng/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Human
Assay Type: Sandwich
Reactivity: Human
Target: MMP10
Sensitivity: 0.06 ng/mL
Detection Range: 0.1-40 ng/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Human
Assay Type: Sandwich
Reactivity: Human
Target: MMP10
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 99-476
Tag: His Tag
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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