MPHOSPH10

This gene encodes a protein that is phosphorylated during mitosis. The protein localizes to the nucleolus during interphase and to the chromosomes during M phase. The protein is thought to be part of the U3 small nucleolar ribonucleoprotein complex, which is involved in rRNA processing. [provided by RefSeq]

Full Name

M-phase phosphoprotein 10 (U3 small nucleolar ribonucleoprotein)

Function

Component of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP). Required for the early cleavages during pre-18S ribosomal RNA processing.

Biological Process

RNA processing Source: UniProtKB
RNA splicing Source: UniProtKB
RNA splicing, via transesterification reactions Source: UniProtKB
rRNA processing Source: UniProtKB-KW

Cellular Location

Nucleus
nucleolus
Other locations
Chromosome
Note: Fibrillar region of the nucleolus (PubMed:9450966). After dissolution of the nucleolus in early M phase becomes associated with chromosomes through metaphase and anaphase (PubMed:9450966). In telophase localized to small cellular prenucleolar bodies that not always contain fibrillarin (PubMed:9450966). The reassociation with nucleolus is preceeded by the arrival of fibrillarin (PubMed:9450966).

PTM

Phosphorylated in M (mitotic) phase.