MT3

This gene is a member of the metallothionein family of genes. Proteins encoded by this gene family are low in molecular weight, are cysteine-rich, lack aromatic residues, and bind divalent heavy metal ions. This gene family member displays tissue-specific expression, and contains a threonine insert near its N-terminus and a glutamate-rich hexapeptide insert near its C-terminus relative to the proteins encoded by other gene family members. It plays an important role in zinc and copper homeostasis, and is induced under hypoxic conditions. The encoded protein is a growth inhibitory factor, and reduced levels of the protein are observed in the brains of individuals with some metal-linked neurodegenerative disorders such as Alzheimer's disease.

metallothionein 3

Binds heavy metals. Contains three zinc and three copper atoms per polypeptide chain and only a negligible amount of cadmium. Inhibits survival and neurite formation of cortical neurons in vitro.

Activation of protein kinase B activity Source: UniProtKB
Astrocyte development Source: UniProtKB
Brain development Source: Ensembl
Cadmium ion homeostasis Source: UniProtKB
Cellular lipid catabolic process Source: UniProtKB
Cellular metal ion homeostasis Source: UniProtKB
Cellular response to cadmium ion Source: UniProtKB
Cellular response to copper ion Source: GO_Central
Cellular response to hypoxia Source: UniProtKB
Cellular response to nitric oxide Source: UniProtKB
Cellular response to oxidative stress Source: UniProtKB
Cellular response to zinc ion Source: GO_Central
Cellular zinc ion homeostasis Source: UniProtKB
Cholesterol catabolic process Source: UniProtKB
Detoxification of copper ion Source: GO_Central
Energy reserve metabolic process Source: UniProtKB
ERK1 and ERK2 cascade Source: UniProtKB
Histone modification Source: UniProtKB
Leptin-mediated signaling pathway Source: UniProtKB
Negative regulation of apoptotic process Source: UniProtKB
Negative regulation of autophagy Source: UniProtKB
Negative regulation of axon extension Source: UniProtKB
Negative regulation of cell growth Source: UniProtKB
Negative regulation of cysteine-type endopeptidase activity Source: UniProtKB
Negative regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: UniProtKB
Negative regulation of hydrogen peroxide catabolic process Source: Ensembl
Negative regulation of necrotic cell death Source: UniProtKB
Negative regulation of neuron apoptotic process Source: UniProtKB
Negative regulation of neuron projection development Source: GO_Central
Negative regulation of oxidoreductase activity Source: UniProtKB
Negative regulation of reactive oxygen species metabolic process Source: UniProtKB
Negative regulation of transcription, DNA-templated Source: UniProtKB
Positive regulation of catalytic activity Source: UniProtKB
Positive regulation of cell death Source: UniProtKB
Positive regulation of ERK1 and ERK2 cascade Source: UniProtKB
Positive regulation of gene expression Source: UniProtKB
Positive regulation of lysosomal membrane permeability Source: UniProtKB
Positive regulation of necrotic cell death Source: UniProtKB
Positive regulation of oxygen metabolic process Source: UniProtKB
Positive regulation of protein phosphorylation Source: UniProtKB
Positive regulation of transcription, DNA-templated Source: UniProtKB
Positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress Source: UniProtKB
Positive regulation of vascular endothelial growth factor receptor signaling pathway Source: UniProtKB
Protein kinase B signaling Source: UniProtKB
Protein stabilization Source: UniProtKB
Regulation of protein glycosylation Source: UniProtKB
Regulation of response to food Source: UniProtKB
Removal of superoxide radicals Source: UniProtKB
Response to hypoxia Source: UniProtKB
Zinc ion homeostasis Source: UniProtKB
Zinc ion transport Source: UniProtKB

Cytoskeleton
microtubule
Cytosol
Endoplasmic reticulum
rough endoplasmic reticulum
extracellular space
Mitochondrion
mitochondrial outer membrane
Nucleus
Plasma Membrane
Other locations
astrocyte end-foot
axon
cytoplasm
dendritic spine
inclusion body
perinuclear region of cytoplasm
postsynaptic density
ribosome
synaptic vesicle