MTPAP

MTPAP is a member of the DNA polymerase type-B-like family. This enzyme synthesizes the 3' poly(A) tail of mitochondrial transcripts and plays a role in replication-dependent histone mRNA degradation.
Full Name
Mitochondrial Poly(A) Polymerase
Function
Polymerase that creates the 3' poly(A) tail of mitochondrial transcripts. Can use all four nucleotides, but has higher activity with ATP and UTP (in vitro). Plays a role in replication-dependent histone mRNA degradation. May be involved in the terminal uridylation of mature histone mRNAs before their degradation is initiated. Might be responsible for the creation of some UAA stop codons which are not encoded in mtDNA.
Biological Process
Histone mRNA catabolic process Source: UniProtKB
mRNA polyadenylation Source: UniProtKB
RNA 3'-end processing Source: GO_Central
Cellular Location
Mitochondrion
Cytoplasm
Involvement in disease
Spastic ataxia 4, autosomal recessive (SPAX4):
A slowly progressive neurodegenerative disease characterized by cerebellar ataxia, spastic paraparesis, dysarthria, and optic atrophy.
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Anti-MTPAP antibodies

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Mouse Anti-MTPAP Recombinant Antibody (3D2) (CBMAB-P0517-YC)

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Target: MTPAP
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 3D2
Application*: WB, IH, IC, IF, P
Datasheet SDS

Mouse Anti-MTPAP Recombinant Antibody (1D3) (CBMAB-P0516-YC)

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Target: MTPAP
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 1D3
Application*: WB, IH, IC, IF, P
Datasheet SDS

Mouse Anti-MTPAP Recombinant Antibody (CBFYM-2767) (CBMAB-M2960-FY)

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Target: MTPAP
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYM-2767
Application*: IF, P, WB
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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