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Mouse Anti-MTPAP Recombinant Antibody (CBFYM-2767) (CBMAB-M2960-FY)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYM-2767
Antibody Isotype
IgG1
Application
IF, IHC-P, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG1
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS
Concentration
1 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Mitochondrial Poly(A) Polymerase
Introduction
The protein encoded by this gene is a member of the DNA polymerase type-B-like family. This enzyme synthesizes the 3' poly tail of mitochondrial transcripts and plays a role in replication-dependent histone mRNA degradation.
Entrez Gene ID
55149
UniProt ID
Q9NVV4
Alternative Names
Mitochondrial Poly(A) Polymerase; PAP-Associated Domain-Containing Protein 1; Polynucleotide Adenylyltransferase; Terminal Uridylyltransferase 1; TUTase 1; PAPD1; Poly(A) RNA Polymerase, Mitochondrial
Function
Polymerase that creates the 3' poly(A) tail of mitochondrial transcripts. Can use all four nucleotides, but has higher activity with ATP and UTP (in vitro). Plays a role in replication-dependent histone mRNA degradation. May be involved in the terminal uridylation of mature histone mRNAs before their degradation is initiated. Might be responsible for the creation of some UAA stop codons which are not encoded in mtDNA.
Biological Process
Histone mRNA catabolic process Source: UniProtKB
mRNA polyadenylation Source: UniProtKB
RNA 3'-end processing Source: GO_Central
Cellular Location
Mitochondrion
Cytoplasm
Involvement in disease
Spastic ataxia 4, autosomal recessive (SPAX4):
A slowly progressive neurodegenerative disease characterized by cerebellar ataxia, spastic paraparesis, dysarthria, and optic atrophy.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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