Mouse Anti-MTPAP Recombinant Antibody (1D3) (CBMAB-P0516-YC)

Name: Mouse Anti-MTPAP Recombinant Antibody (1D3)
SKU: CBMAB-P0516-YC
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

1D3

Application

WB, IHC, ICC, IF, IHC-P

Specificity

Human

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Mitochondrial Poly(A) Polymerase

Introduction

MTPAP is a member of the DNA polymerase type-B-like family. This enzyme synthesizes the 3' poly(A) tail of mitochondrial transcripts and plays a role in replication-dependent histone mRNA degradation.

Entrez Gene ID

55149

UniProt ID

Q9NVV4

Alternative Names

PAPD1; SPAX4

Function

Polymerase that creates the 3' poly(A) tail of mitochondrial transcripts. Can use all four nucleotides, but has higher activity with ATP and UTP (in vitro). Plays a role in replication-dependent histone mRNA degradation. May be involved in the terminal uridylation of mature histone mRNAs before their degradation is initiated. Might be responsible for the creation of some UAA stop codons which are not encoded in mtDNA.

Biological Process

Histone mRNA catabolic process Source: UniProtKB
mRNA polyadenylation Source: UniProtKB
RNA 3'-end processing Source: GO_Central

Cellular Location

Mitochondrion
Cytoplasm

Involvement in disease

Spastic ataxia 4, autosomal recessive (SPAX4):
A slowly progressive neurodegenerative disease characterized by cerebellar ataxia, spastic paraparesis, dysarthria, and optic atrophy.

Van Eyck, L., Bruni, F., Ronan, A., Briggs, T. A., Roscioli, T., Rice, G. I., ... & Crow, Y. J. (2020). Biallelic mutations in MTPAP associated with a lethal encephalopathy. Neuropediatrics, 51(03), 178-184.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Related Products

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Mouse Anti-MTPAP Recombinant Antibody (CBFYM-2767) (CAT#: CBMAB-M2960-FY)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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