Mydgf

The protein encoded by this gene was previously thought to support proliferation of lymphoid cells and was considered an interleukin. However, this activity has not been reproducible and the function of this protein is currently unknown. [provided by RefSeq, Jul 2008]

Myeloid Derived Growth Factor

Bone marrow-derived monocyte and paracrine-acting protein that promotes cardiac myocyte survival and adaptive angiogenesis for cardiac protection and/or repair after myocardial infarction (MI). Stimulates endothelial cell proliferation through a MAPK1/3-, STAT3- and CCND1-mediated signaling pathway. Inhibits cardiac myocyte apoptosis in a PI3K/AKT-dependent signaling pathway (By similarity).

Involved in endothelial cell proliferation and angiogenesis (PubMed:25581518).

Angiogenesis Source: UniProtKB-KW
Apoptotic process Source: UniProtKB-KW
Negative regulation of apoptotic process Source: UniProtKB
Positive regulation of angiogenesis Source: UniProtKB
Positive regulation of endothelial cell proliferation Source: UniProtKB
Positive regulation of MAPK cascade Source: UniProtKB
Positive regulation of phosphatidylinositol 3-kinase signaling Source: UniProtKB
Positive regulation of protein kinase B signaling Source: UniProtKB
Positive regulation of protein phosphorylation Source: UniProtKB
Positive regulation of transcription by RNA polymerase II Source: UniProtKB

Golgi apparatus
Secreted
Endoplasmic reticulum
Other locations
Endoplasmic reticulum-Golgi intermediate compartment
Note: The C-terminal RTEL motif may provide retention in the endoplasmic reticulum.