Mydgf

The protein encoded by this gene was previously thought to support proliferation of lymphoid cells and was considered an interleukin. However, this activity has not been reproducible and the function of this protein is currently unknown. [provided by RefSeq, Jul 2008]
Full Name
Myeloid Derived Growth Factor
Function
Bone marrow-derived monocyte and paracrine-acting protein that promotes cardiac myocyte survival and adaptive angiogenesis for cardiac protection and/or repair after myocardial infarction (MI). Stimulates endothelial cell proliferation through a MAPK1/3-, STAT3- and CCND1-mediated signaling pathway. Inhibits cardiac myocyte apoptosis in a PI3K/AKT-dependent signaling pathway (By similarity).

Involved in endothelial cell proliferation and angiogenesis (PubMed:25581518).
Biological Process
Angiogenesis Source: UniProtKB-KW
Apoptotic process Source: UniProtKB-KW
Negative regulation of apoptotic process Source: UniProtKB
Positive regulation of angiogenesis Source: UniProtKB
Positive regulation of endothelial cell proliferation Source: UniProtKB
Positive regulation of MAPK cascade Source: UniProtKB
Positive regulation of phosphatidylinositol 3-kinase signaling Source: UniProtKB
Positive regulation of protein kinase B signaling Source: UniProtKB
Positive regulation of protein phosphorylation Source: UniProtKB
Positive regulation of transcription by RNA polymerase II Source: UniProtKB
Cellular Location
Golgi apparatus
Secreted
Endoplasmic reticulum
Other locations
Endoplasmic reticulum-Golgi intermediate compartment
Note: The C-terminal RTEL motif may provide retention in the endoplasmic reticulum.
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Anti-Mydgf antibodies

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Rat Anti-MYDGF (AA 32-173) Recombinant Antibody (CBFYM-2906) (CBMAB-M3101-FY)

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Target: MYDGF
Host: Rat
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBFYM-2906
Application*: WB, IF
Datasheet SDS

Mouse Anti-MYDGF Recombinant Antibody (2D4) (CBMAB-A0945-LY)

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Target: MYDGF
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 2D4
Application*: IF, E
Datasheet SDS

Mouse Anti-MYDGF Recombinant Antibody (2D4) (CBMAB-C4899-LY)

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Target: MYDGF
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 2D4
Application*: E, IF
Datasheet SDS

Rabbit Anti-MYDGF Recombinant Antibody (CBXS-1348) (CBMAB-S4206-CQ)

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Target: MYDGF
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBXS-1348
Application*: WB, F
Datasheet SDS

Mouse Anti-MYDGF Recombinant Antibody (CBFYM-0764) (CBMAB-M0907-FY)

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Target: MYDGF
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBFYM-0764
Application*: E
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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