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Rat Anti-MYDGF (AA 32-173) Recombinant Antibody (CBFYM-2906) (CBMAB-M3101-FY)

This product is rat antibody that recognizes MYDGF. The antibody CBFYM-2906 can be used for immunoassay techniques such as: WB, IF.
See all MYDGF antibodies

Summary

Host Animal
Rat
Specificity
Human
Clone
CBFYM-2906
Antibody Isotype
IgG2a, k
Application
WB, IF

Basic Information

Immunogen
Recombinant protein (32-173 a.a.) expressed in E. coli
Specificity
Human
Antibody Isotype
IgG2a, k
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.2
Preservative
0.09% Sodium azide
Concentration
0.5 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
AA 32-173

Target

Full Name
Myeloid Derived Growth Factor
Introduction
The protein encoded by this gene was previously thought to support proliferation of lymphoid cells and was considered an interleukin. However, this activity has not been reproducible and the function of this protein is currently unknown.
Entrez Gene ID
56005
UniProt ID
Q969H8
Alternative Names
Myeloid Derived Growth Factor; Stromal Cell-Derived Growth Factor SF20; Interleukin 27 Working Designation; Interleukin-25; C19orf10; IL25; Chromosome 19 Open Reading Frame 10; Myeloid-Derived Growth Factor
Function
Bone marrow-derived monocyte and paracrine-acting protein that promotes cardiac myocyte survival and adaptive angiogenesis for cardiac protection and/or repair after myocardial infarction (MI). Stimulates endothelial cell proliferation through a MAPK1/3-, STAT3- and CCND1-mediated signaling pathway. Inhibits cardiac myocyte apoptosis in a PI3K/AKT-dependent signaling pathway (By similarity).

Involved in endothelial cell proliferation and angiogenesis (PubMed:25581518).
Biological Process
Angiogenesis Source: UniProtKB-KW
Apoptotic process Source: UniProtKB-KW
Negative regulation of apoptotic process Source: UniProtKB
Positive regulation of angiogenesis Source: UniProtKB
Positive regulation of endothelial cell proliferation Source: UniProtKB
Positive regulation of MAPK cascade Source: UniProtKB
Positive regulation of phosphatidylinositol 3-kinase signaling Source: UniProtKB
Positive regulation of protein kinase B signaling Source: UniProtKB
Positive regulation of protein phosphorylation Source: UniProtKB
Positive regulation of transcription by RNA polymerase II Source: UniProtKB
Cellular Location
Golgi apparatus
Secreted
Endoplasmic reticulum
Other locations
Endoplasmic reticulum-Golgi intermediate compartment
Note: The C-terminal RTEL motif may provide retention in the endoplasmic reticulum.

Sim, R., Yang, C., & Yang, Y. Y. (2024). Chemical Proteomics and Morphological Profiling Revealing MYDGF as a Target for Synthetic Anticancer Macromolecules. Biomacromolecules.

Huang, S., Kou, H., Zheng, Z., Lu, M., Wu, L., & Zheng, H. (2024). GelMA-PVAMA hydrogel loaded with MYDGF accelerates wound healing by promoting angiogenesis. International Journal of Polymeric Materials and Polymeric Biomaterials, 1-10.

Xu, J., Ma, H., Shi, L., Zhou, H., Cheng, Y., Tong, J., ... & Xiang, G. (2023). Inflammatory cell–derived MYDGF attenuates endothelial LDL transcytosis to protect against atherogenesis. Arteriosclerosis, Thrombosis, and Vascular Biology, 43(11), e443-e467.

Xu, X., Li, Y., Shi, L., He, K., Sun, Y., Ding, Y., ... & Xiang, G. (2022). Myeloid‐derived growth factor (MYDGF) protects bone mass through inhibiting osteoclastogenesis and promoting osteoblast differentiation. EMBO reports, 23(3), e53509.

Wang, Y., Zhang, Y., Li, J., Zhao, R., Long, X., Li, C., ... & Shi, B. (2022). Role of Mydgf in the regulation of hypoxia/reoxygenation-induced apoptosis in cardiac microvascular endothelial cells. In Vitro Cellular & Developmental Biology-Animal, 58(8), 669-678.

Wang, Y., Li, Y., Feng, J., Liu, W., Li, Y., Liu, J., ... & Nie, Y. (2020). Mydgf promotes Cardiomyocyte proliferation and Neonatal Heart regeneration. Theranostics, 10(20), 9100.

He, M., Li, Y., Wang, L., Guo, B., Mei, W., Zhu, B., ... & Xiang, G. (2020). MYDGF attenuates podocyte injury and proteinuria by activating Akt/BAD signal pathway in mice with diabetic kidney disease. Diabetologia, 63, 1916-1931.

Ebenhoch, R., Akhdar, A., Reboll, M. R., Korf-Klingebiel, M., Gupta, P., Armstrong, J., ... & Nar, H. (2019). Crystal structure and receptor-interacting residues of MYDGF—a protein mediating ischemic tissue repair. Nature communications, 10(1), 5379.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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