Human Recombinant SF20 protein, Fc Tag (V2LY-0526-LY6745)

Name: Human Recombinant SF20 protein, Fc Tag
SKU: V2LY-0526-LY6745
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

HEK293 Cells

Protein Species

Human

Tag

Fc Tag

Protein Construction

This product is Human Recombinant SF20 protein, Fc Tag consist of Amino Acid: 1-173 and predicts a molecular mass of 42.2 kDa.

Molecule Mass

42.2 kDa

Sequence

Amino Acid: 1-173

Species

Human

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

>90% as determined by SDS-PAGE.

Endotoxin

Please contact us for more information.

Format

Lyophilized

Reconstitution

Allow the vial and reconstitution buffer to equilibrate to room temperature. Briefly centrifuge or tap down the vial to ensure that all lyophilized powder is collected at the bottom of the vial. For the reconstitution of this product, we recommend adding PBS or sterile water to achieve a final antibody concentration of 1 mg/mL. Allow the vial to reconstitute for 10-15 minutes at room temperature with gentle agitation. Avoid vigorous shaking that can cause foaming and antibody denaturation. Aliquot into volumes based on your experiment and store liquid protein at -20°C or -80°C for long time.

Buffer

Lyophilized from sterile PBS

Preservative

None

Storage

Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

More Infomation

Target

Full Name

Myeloid Derived Growth Factor

Function

Bone marrow-derived monocyte and paracrine-acting protein that promotes cardiac myocyte survival and adaptive angiogenesis for cardiac protection and/or repair after myocardial infarction (MI). Stimulates endothelial cell proliferation through a MAPK1/3-, STAT3- and CCND1-mediated signaling pathway. Inhibits cardiac myocyte apoptosis in a PI3K/AKT-dependent signaling pathway (By similarity).

Involved in endothelial cell proliferation and angiogenesis (PubMed:25581518).

Biological Process

Angiogenesis Source: UniProtKB-KW
Apoptotic process Source: UniProtKB-KW
Negative regulation of apoptotic process Source: UniProtKB
Positive regulation of angiogenesis Source: UniProtKB
Positive regulation of endothelial cell proliferation Source: UniProtKB
Positive regulation of MAPK cascade Source: UniProtKB
Positive regulation of phosphatidylinositol 3-kinase signaling Source: UniProtKB
Positive regulation of protein kinase B signaling Source: UniProtKB
Positive regulation of protein phosphorylation Source: UniProtKB
Positive regulation of transcription by RNA polymerase II Source: UniProtKB

Cellular Location

Golgi apparatus
Secreted
Endoplasmic reticulum
Other locations
Endoplasmic reticulum-Golgi intermediate compartment
Note: The C-terminal RTEL motif may provide retention in the endoplasmic reticulum.

Sim, R., Yang, C., & Yang, Y. Y. (2024). Chemical Proteomics and Morphological Profiling Revealing MYDGF as a Target for Synthetic Anticancer Macromolecules. Biomacromolecules.

Huang, S., Kou, H., Zheng, Z., Lu, M., Wu, L., & Zheng, H. (2024). GelMA-PVAMA hydrogel loaded with MYDGF accelerates wound healing by promoting angiogenesis. International Journal of Polymeric Materials and Polymeric Biomaterials, 1-10.

Xu, J., Ma, H., Shi, L., Zhou, H., Cheng, Y., Tong, J., ... & Xiang, G. (2023). Inflammatory cell–derived MYDGF attenuates endothelial LDL transcytosis to protect against atherogenesis. Arteriosclerosis, Thrombosis, and Vascular Biology, 43(11), e443-e467.

Xu, X., Li, Y., Shi, L., He, K., Sun, Y., Ding, Y., ... & Xiang, G. (2022). Myeloid‐derived growth factor (MYDGF) protects bone mass through inhibiting osteoclastogenesis and promoting osteoblast differentiation. EMBO reports, 23(3), e53509.

Wang, Y., Zhang, Y., Li, J., Zhao, R., Long, X., Li, C., ... & Shi, B. (2022). Role of Mydgf in the regulation of hypoxia/reoxygenation-induced apoptosis in cardiac microvascular endothelial cells. In Vitro Cellular & Developmental Biology-Animal, 58(8), 669-678.

Wang, Y., Li, Y., Feng, J., Liu, W., Li, Y., Liu, J., ... & Nie, Y. (2020). Mydgf promotes Cardiomyocyte proliferation and Neonatal Heart regeneration. Theranostics, 10(20), 9100.

He, M., Li, Y., Wang, L., Guo, B., Mei, W., Zhu, B., ... & Xiang, G. (2020). MYDGF attenuates podocyte injury and proteinuria by activating Akt/BAD signal pathway in mice with diabetic kidney disease. Diabetologia, 63, 1916-1931.

Ebenhoch, R., Akhdar, A., Reboll, M. R., Korf-Klingebiel, M., Gupta, P., Armstrong, J., ... & Nar, H. (2019). Crystal structure and receptor-interacting residues of MYDGF—a protein mediating ischemic tissue repair. Nature communications, 10(1), 5379.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Human Recombinant SF20 protein, His Tag (CAT#: V2LY-0526-LY6744)

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Human Recombinant SF20 protein, His Tag (CAT#: V2LY-0526-LY6744)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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