NAMPT

This gene encodes a protein that catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, one step in the biosynthesis of nicotinamide adenine dinucleotide. The protein belongs to the nicotinic acid phosphoribosyltransferase (NAPRTase) family and is thought to be involved in many important biological processes, including metabolism, stress response and aging. This gene has a pseudogene on chromosome 10. [provided by RefSeq, Feb 2011]
Full Name
Nicotinamide Phosphoribosyltransferase
Function
Catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, an intermediate in the biosynthesis of NAD. It is the rate limiting component in the mammalian NAD biosynthesis pathway. The secreted form behaves both as a cytokine with immunomodulating properties and an adipokine with anti-diabetic properties, it has no enzymatic activity, partly because of lack of activation by ATP, which has a low level in extracellular space and plasma. Plays a role in the modulation of circadian clock function. NAMPT-dependent oscillatory production of NAD regulates oscillation of clock target gene expression by releasing the core clock component: CLOCK-ARNTL/BMAL1 heterodimer from NAD-dependent SIRT1-mediated suppression (By similarity).
Biological Process
Cell-cell signaling Source: ProtInc
Circadian regulation of gene expression Source: UniProtKB
NAD biosynthesis via nicotinamide riboside salvage pathway Source: Reactome
NAD biosynthetic process Source: GO_Central
Positive regulation of cell population proliferation Source: ProtInc
Positive regulation of nitric-oxide synthase biosynthetic process Source: BHF-UCL
Positive regulation of transcription by RNA polymerase II Source: BHF-UCL
Signal transduction Source: ProtInc
Cellular Location
Nucleus
Cytoplasm
Secreted
Note: Under non-inflammatory conditions, visfatin predominantly exhibits a granular pattern within the nucleus. Secreted by endothelial cells upon IL-1beta stimulation. Abundantly secreted in milk, reaching 100-fold higher concentrations compared to maternal serum.
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Anti-NAMPT antibodies

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Mouse Anti-NAMPT Recombinant Antibody (CF301) (CBMAB-FT043LY)

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Target: NAMPT
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human, Mouse, Rat
Clone: CF301
Application*: ELISA, WB, IHC, IF
Datasheet SDS

Mouse Anti-NAMPT Recombinant Antibody (CBT994) (V2LY-0625-LY3116)

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Target: NAMPT
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBT994
Application*: WB, E
Datasheet SDS

Mouse Anti-NAMPT Recombinant Antibody (CBT995) (V2LY-0625-LY3115)

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Target: NAMPT
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBT995
Application*: WB, E
Datasheet SDS

Mouse Anti-NAMPT Recombinant Antibody (CBT4046) (V2LY-0625-LY2153)

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Target: NAMPT
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT4046
Application*: WB
Datasheet SDS

Mouse Anti-NAMPT Recombinant Antibody (CBT3808) (V2LY-0625-LY2070)

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Target: NAMPT
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT3808
Application*: WB
Datasheet SDS

Mouse Anti-NAMPT Recombinant Antibody (A1286) (CBMAB-AP12453LY)

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Target: NAMPT
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human, Mouse, Rat
Clone: A1286
Application*: ELISA, IF, IHC, WB
Datasheet SDS

Anti-NAMPT Recombinant Antibody (4E11C9) (CBMAB-AO773LY)

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Target: NAMPT
Antibody Isotype: IgG
Specificity: Human
Clone: 4E11C9
Application*: WB
Datasheet SDS

Rabbit Anti-NAMPT Recombinant Antibody (CBR058F) (CBMAB-BT063LY)

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Target: NAMPT
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse
Clone: CBR058F
Application*: WB, IP, IHC, ICC, F
Datasheet SDS

Rabbit Anti-NAMPT Recombinant Antibody (D1K6D) (CBMAB-P0529-YC)

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Target: NAMPT
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: D1K6D
Application*: IP, WB
Datasheet SDS

Mouse Anti-NAMPT Recombinant Antibody (CBYC-P112) (CBMAB-P0528-YC)

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Target: NAMPT
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat
Clone: CBYC-P112
Application*: WB
Datasheet SDS

Rat Anti-NAMPT Recombinant Antibody (CBYC-P111) (CBMAB-P0526-YC)

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Target: NAMPT
Host: Rat
Antibody Isotype: IgG2a
Specificity: Human, Mouse
Clone: CBYC-P111
Application*: IS
Datasheet SDS

Rabbit Anti-NAMPT Recombinant Antibody (CBWJN-1164) (CBMAB-N1100-WJ)

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Target: NAMPT
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse, Rat, Human
Clone: CBWJN-1164
Application*: WB, P, IC
Datasheet SDS

Mouse Anti-NAMPT Recombinant Antibody (CBWJN-0560) (CBMAB-N1099-WJ)

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Target: NAMPT
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBWJN-0560
Application*: E, IP
Datasheet SDS

Mouse Anti-NAMPT Recombinant Antibody (4E11C9) (CBMAB-N1098-WJ)

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Target: NAMPT
Host: Mouse
Antibody Isotype: IgG1
Specificity: Cattle, Human
Clone: 4E11C9
Application*: E, WB
Datasheet SDS

Rabbit Anti-NAMPT Recombinant Antibody (21HCLC) (CBMAB-N1096-WJ)

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Target: NAMPT
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: 21HCLC
Application*: WB
Datasheet SDS

Mouse Anti-NAMPT Recombinant Antibody (1D3A12) (CBMAB-N1095-WJ)

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Target: NAMPT
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 1D3A12
Application*: WB, E
Datasheet SDS

Rabbit Anti-NAMPT Recombinant Antibody (13H13L23) (CBMAB-N1092-WJ)

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Target: NAMPT
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: 13H13L23
Application*: F, IC, IF, WB
Datasheet SDS

Rat Anti-NAMPT Recombinant Antibody (CBWJN-1162) (CBMAB-N1088-WJ)

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Target: NAMPT
Host: Rat
Antibody Isotype: IgG2a
Specificity: Human, Mouse
Clone: CBWJN-1162
Application*: F, WB
Datasheet SDS

Mouse Anti-NAMPT Recombinant Antibody (CBWJN-0943) (CBMAB-N0112-WJ)

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Target: NAMPT
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBWJN-0943
Application*: E, WB
Datasheet SDS

Mouse Anti-NAMPT Recombinant Antibody (OMNI379) (CBMAB-V0207-LY)

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Target: NAMPT
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human, Rat
Clone: OMNI379
Application*: E, WB, P, IF/IC, IP, F
Datasheet SDS

Mouse Anti-NAMPT Monoclonal Antibody (4D5) (CBMAB-1712-YC)

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Target: NAMPT
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 4D5
Application*: E, WB
Datasheet SDS

Rat Anti-NAMPT Monoclonal Antibody (14A5) (CBMAB-1711-YC)

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Target: NAMPT
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse, Human
Clone: 14A5
Application*: E, C, WB
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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