NANOS1

This gene encodes a CCHC-type zinc finger protein that is a member of the nanos family. This protein co-localizes with the RNA-binding protein pumilio RNA-binding family member 2 and may be involved in regulating translation as a post-transcriptional repressor. Mutations in this gene are associated with spermatogenic impairment. [provided by RefSeq, Sep 2015]

Full Name

nanos homolog 1 (Drosophila)

Function

May act as a translational repressor which regulates translation of specific mRNAs by forming a complex with PUM2 that associates with the 3'-UTR of mRNA targets. Capable of interfering with the proadhesive and anti-invasive functions of E-cadherin. Up-regulates the production of MMP14 to promote tumor cell invasion.

Biological Process

Cell migration Source: UniProtKB
Cerebellar neuron development Source: Ensembl
Epithelial cell migration Source: UniProtKB
Negative regulation of translation Source: BHF-UCL
Oogenesis Source: GO_Central
Positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay Source: BHF-UCL
Posttranscriptional regulation of gene expression Source: MGI
Regulation of cell growth Source: Ensembl
Tissue homeostasis Source: Ensembl

Cellular Location

Cytoplasm
Other locations
perinuclear region
Note: Colocalizes with SNAPIN and PUM2 in the perinuclear region of germ cells.

Involvement in disease

Spermatogenic failure 12 (SPGF12):
An infertility disorder caused by spermatogenesis defects. It results in decreased sperm motility, concentration, and multiple sperm structural defects. Non-obstructive azoospermia, oligozoospermia and oligo-astheno-teratozoospermia are features observed in SPGF12 patients.