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Mouse Anti-NANOS1 Recombinant Antibody (5F12) (CBMAB-N1123-WJ)

This product is a Mouse antibody that recognizes NANOS1. The antibody 5F12 can be used for immunoassay techniques such as: WB, IP, ELISA.
See all NANOS1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
5F12
Antibody Isotype
IgG1, κ
Application
WB, IP, ELISA

Basic Information

Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
nanos homolog 1 (Drosophila)
Introduction
This gene encodes a CCHC-type zinc finger protein that is a member of the nanos family. This protein co-localizes with the RNA-binding protein pumilio RNA-binding family member 2 and may be involved in regulating translation as a post-transcriptional repressor. Mutations in this gene are associated with spermatogenic impairment. [provided by RefSeq, Sep 2015]
Entrez Gene ID
340719
UniProt ID
Q8WY41
Alternative Names
Nanos C2HC-Type Zinc Finger 1; EC_Rep1a; NOS-1; NOS1; Nanos Homolog 1 (Drosophila); Nanos Homolog 1; ZC2HC12A; SPGF12;
Function
May act as a translational repressor which regulates translation of specific mRNAs by forming a complex with PUM2 that associates with the 3'-UTR of mRNA targets. Capable of interfering with the proadhesive and anti-invasive functions of E-cadherin. Up-regulates the production of MMP14 to promote tumor cell invasion.
Biological Process
Cell migration Source: UniProtKB
Cerebellar neuron development Source: Ensembl
Epithelial cell migration Source: UniProtKB
Negative regulation of translation Source: BHF-UCL
Oogenesis Source: GO_Central
Positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay Source: BHF-UCL
Posttranscriptional regulation of gene expression Source: MGI
Regulation of cell growth Source: Ensembl
Tissue homeostasis Source: Ensembl
Cellular Location
Cytoplasm
Other locations
perinuclear region
Note: Colocalizes with SNAPIN and PUM2 in the perinuclear region of germ cells.
Involvement in disease
Spermatogenic failure 12 (SPGF12):
An infertility disorder caused by spermatogenesis defects. It results in decreased sperm motility, concentration, and multiple sperm structural defects. Non-obstructive azoospermia, oligozoospermia and oligo-astheno-teratozoospermia are features observed in SPGF12 patients.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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