NAPEPLD

NAPEPLD is a phospholipase D type enzyme that catalyzes the release of N-acylethanolamine (NAE) from N-acyl-phosphatidylethanolamine (NAPE) in the second step of the biosynthesis of N-acylethanolamine (Okamoto et al., 2004 [PubMed 14634025]).[supplied by OMIM, Oct 2008]

Full Name

N-Acyl Phosphatidylethanolamine Phospholipase D

Function

D-type phospholipase that hydrolyzes N-acyl-phosphatidylethanolamines (NAPEs) to produce bioactive N-acylethanolamines/fatty acid ethanolamides (NAEs/FAEs) and phosphatidic acid (PubMed:14634025, PubMed:16527816, PubMed:27571266, PubMed:25684574).

Cleaves the terminal phosphodiester bond of diacyl- and alkenylacyl-NAPEs, primarily playing a role in the generation of long-chain saturated and monounsaturated NAEs in the brain (By similarity).

May control NAPE homeostasis in dopaminergic neuron membranes and regulate neuron survival, partly through RAC1 activation (By similarity).

As a regulator of lipid metabolism in the adipose tissue, mediates the crosstalk between adipocytes, gut microbiota and immune cells to control body temperature and weight. In particular, regulates energy homeostasis by promoting cold-induced brown or beige adipocyte differentiation program to generate heat from fatty acids and glucose. Has limited D-type phospholipase activity toward N-acyl lyso-NAPEs (By similarity).

Biological Process

Host-mediated regulation of intestinal microbiota composition Source: UniProtKB
N-acylethanolamine metabolic process Source: GO_Central
N-acylphosphatidylethanolamine metabolic process Source: UniProtKB
Phospholipid catabolic process Source: UniProtKB-KW
Positive regulation of brown fat cell differentiation Source: UniProtKB
Positive regulation of inflammatory response Source: UniProtKB
Retinoid metabolic process Source: Reactome
Temperature homeostasis Source: UniProtKB

Cellular Location

Nucleus
Nucleus envelope
nucleoplasm
Golgi apparatus
Golgi apparatus membrane
Endosome
Early endosome membrane
Note: Localized in the proximity of the cellular membranes likely through interaction with membrane phospholipids.