NBL1

This gene product is the founding member of the evolutionarily conserved CAN (Cerberus and DAN) family of proteins, which contain a domain resembling the CTCK (C-terminal cystine knot-like) motif found in a number of signaling molecules. These proteins are secreted, and act as BMP (bone morphogenetic protein) antagonists by binding to BMPs and preventing them from interacting with their receptors. They may thus play an important role during growth and development. Alternatively spliced transcript variants have been identified for this gene. Read-through transcripts between this locus and the upstream mitochondrial inner membrane organizing system 1 gene (GeneID 440574) have been observed. [provided by RefSeq, May 2013]

Neuroblastoma 1, DAN Family BMP Antagonist

Possible candidate as a tumor suppressor gene of neuroblastoma. May play an important role in preventing cells from entering the final stage (G1/S) of the transformation process.

Animal organ morphogenesis Source: GO_Central
Determination of dorsal identity Source: BHF-UCL
Negative regulation of BMP signaling pathway Source: UniProtKB
Negative regulation of monocyte chemotaxis Source: BHF-UCL
Nervous system development Source: BHF-UCL
Neuron projection morphogenesis Source: BHF-UCL
Positive regulation of neuron differentiation Source: BHF-UCL
Sequestering of BMP from receptor via BMP binding Source: UniProtKB
Sequestering of BMP in extracellular matrix Source: BHF-UCL

Secreted