NBL1

This gene product is the founding member of the evolutionarily conserved CAN (Cerberus and DAN) family of proteins, which contain a domain resembling the CTCK (C-terminal cystine knot-like) motif found in a number of signaling molecules. These proteins are secreted, and act as BMP (bone morphogenetic protein) antagonists by binding to BMPs and preventing them from interacting with their receptors. They may thus play an important role during growth and development. Alternatively spliced transcript variants have been identified for this gene. Read-through transcripts between this locus and the upstream mitochondrial inner membrane organizing system 1 gene (GeneID 440574) have been observed. [provided by RefSeq, May 2013]
Full Name
Neuroblastoma 1, DAN Family BMP Antagonist
Function
Possible candidate as a tumor suppressor gene of neuroblastoma. May play an important role in preventing cells from entering the final stage (G1/S) of the transformation process.
Biological Process
Animal organ morphogenesis Source: GO_Central
Determination of dorsal identity Source: BHF-UCL
Negative regulation of BMP signaling pathway Source: UniProtKB
Negative regulation of monocyte chemotaxis Source: BHF-UCL
Nervous system development Source: BHF-UCL
Neuron projection morphogenesis Source: BHF-UCL
Positive regulation of neuron differentiation Source: BHF-UCL
Sequestering of BMP from receptor via BMP binding Source: UniProtKB
Sequestering of BMP in extracellular matrix Source: BHF-UCL
Cellular Location
Secreted
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Anti-NBL1 antibodies

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Mouse Anti-NBL1 Recombinant Antibody (A1295) (CBMAB-AP4990LY)

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Target: NBL1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: A1295
Application*: Dot blot, ELISA, WB
Datasheet SDS

Rat Anti-NBL1 Recombinant Antibody (CBWJN-0845) (CBMAB-N1250-WJ)

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Target: NBL1
Host: Rat
Antibody Isotype: IgG2
Specificity: Mouse
Clone: CBWJN-0845
Application*: WB
Datasheet SDS

Rabbit Anti-NBL1 Recombinant Antibody (CBWJN-1185) (CBMAB-N1249-WJ)

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Target: NBL1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBWJN-1185
Application*: WB, F, IC
Datasheet SDS

Mouse Anti-NBL1 Recombinant Antibody (AT38G8) (CBMAB-N1248-WJ)

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Target: NBL1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: AT38G8
Application*: E, F, IC, WB
Datasheet SDS

Mouse Anti-NBL1 Recombinant Antibody (7F8A9D4) (CBMAB-N1245-WJ)

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Target: NBL1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 7F8A9D4
Application*: E
Datasheet SDS

Mouse Anti-NBL1 Recombinant Antibody (1G5) (CBMAB-N1243-WJ)

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Target: NBL1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 1G5
Application*: E, WB
Datasheet SDS

Mouse Anti-NBL1 Recombinant Antibody (CBWJN-0247) (CBMAB-N1242-WJ)

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Target: NBL1
Host: Mouse
Specificity: Human
Clone: CBWJN-0247
Application*: E, WB
Datasheet SDS

Mouse Anti-NBL1 Recombinant Antibody (CBWJN-1184) (CBMAB-N1241-WJ)

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Target: NBL1
Host: Mouse
Specificity: Human
Clone: CBWJN-1184
Application*: EC
Datasheet SDS

Mouse Anti-NBL1 Recombinant Antibody (CBWJN-1183) (CBMAB-N1240-WJ)

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Target: NBL1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBWJN-1183
Application*: ED, P
Datasheet SDS

Mouse Anti-NBL1 Recombinant Antibody (CBWJN-1182) (CBMAB-N1239-WJ)

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Target: NBL1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBWJN-1182
Application*: P
Datasheet SDS

Rat Anti-NBL1 Recombinant Antibody (15H37) (CBMAB-D2136-YC)

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Target: NBL1
Host: Rat
Antibody Isotype: IgG
Specificity: Mouse
Clone: 15H37
Application*: WB
Datasheet SDS

Rat Anti-NBL1 Recombinant Antibody (14L347) (CBMAB-D2135-YC)

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Target: NBL1
Host: Rat
Antibody Isotype: IgG2
Specificity: Mouse
Clone: 14L347
Application*: WB
Datasheet SDS

Mouse Anti-NBL1 Recombinant Antibody (38G8) (CBMAB-D2130-YC)

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Target: NBL1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 38G8
Application*: WB, E
Datasheet SDS

Mouse Anti-NBL1 Recombinant Antibody (14L346) (CBMAB-D2128-YC)

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Target: NBL1
Host: Mouse
Antibody Isotype: IgG2
Specificity: Human
Clone: 14L346
Application*: WB
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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