Mouse Anti-NBL1 Recombinant Antibody (CBWJN-1182) (CBMAB-N1239-WJ)

Name: Mouse Anti-NBL1 Recombinant Antibody (CBWJN-1182)
SKU: CBMAB-N1239-WJ
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBWJN-1182

Application

IHC-P

Specificity

Human

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Neuroblastoma 1, DAN Family BMP Antagonist

Introduction

This gene product is the founding member of the evolutionarily conserved CAN (Cerberus and DAN) family of proteins, which contain a domain resembling the CTCK (C-terminal cystine knot-like) motif found in a number of signaling molecules. These proteins are secreted, and act as BMP (bone morphogenetic protein) antagonists by binding to BMPs and preventing them from interacting with their receptors. They may thus play an important role during growth and development. Alternatively spliced transcript variants have been identified for this gene. Read-through transcripts between this locus and the upstream mitochondrial inner membrane organizing system 1 gene (GeneID 440574) have been observed. [provided by RefSeq, May 2013]

Entrez Gene ID

4681

UniProt ID

P41271

Alternative Names

Neuroblastoma 1, DAN Family BMP Antagonist; Neuroblastoma Candidate Region, Suppression Of Tumorigenicity 1; Differential Screening-Selected Gene Aberrant In Neuroblastoma; Neuroblastoma Suppressor Of Tumorigenicity 1; DAN Domain Family Member 1; DAND1; DAN;

Function

Possible candidate as a tumor suppressor gene of neuroblastoma. May play an important role in preventing cells from entering the final stage (G1/S) of the transformation process.

Biological Process

Animal organ morphogenesis Source: GO_Central
Determination of dorsal identity Source: BHF-UCL
Negative regulation of BMP signaling pathway Source: UniProtKB
Negative regulation of monocyte chemotaxis Source: BHF-UCL
Nervous system development Source: BHF-UCL
Neuron projection morphogenesis Source: BHF-UCL
Positive regulation of neuron differentiation Source: BHF-UCL
Sequestering of BMP from receptor via BMP binding Source: UniProtKB
Sequestering of BMP in extracellular matrix Source: BHF-UCL

Cellular Location

Secreted

Tsai, C. H., Liu, E., Phan, A., Lu, K. L., & Mei, H. (2023). NBL1 Reduces Corneal Fibrosis and Scar Formation after Wounding. Biomolecules, 13(11), 1570.

Lu, L., Zha, Z., Zhang, P., Wang, P., Liu, X., Fang, X., ... & Liu, G. (2022). Neuron-specific enolase promotes stem cell-like characteristics of small-cell lung cancer by downregulating NBL1 and activating the BMP2/Smad/ID1 pathway. Oncogenesis, 11(1), 21.

Correns, A., Zimmermann, L. M. A., Baldock, C., & Sengle, G. (2021). BMP antagonists in tissue development and disease. Matrix Biology Plus, 11, 100071.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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